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Focal Controlled Drug Delivery pp 329–341Cite as

Segmental-Dependent Drug Absorption and Delivery: The Stomach

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Part of the Advances in Delivery Science and Technology book series (ADST)

Abstract

The gastrointestinal tract (GIT) is a long and complex organ, with significantly variable characteristics throughout. It is broadly divided to several segments: the stomach; the small intestine which is subdivided to duodenum, jejunum, and ileum; and the colon. Each segment has its own unique environment. Conditions in each segment are dependent on a multitude of factors. The focus of this chapter is gastroretentive dosage form (GRDF). This term encompasses several technologies with one common feature: they are designed to resist the normal tendency of the stomach to clear its content, resulting in a targeted and controlled release of the active moiety to the upper GI tract. A special emphasis is given for the rationale for GRDF, different GRDF technologies, and their unique application. In conclusion, segment-specific targeting technologies are a highly important research field; a thorough understanding of the determinants of gastrointestinal environment, considering the whole of the human intestine, is crucial for successful targeting of drugs to specific gastrointestinal regions and exploitation of the variable intestinal conditions for better drug delivery and therapeutic effect.

Keywords

  • Drug Release
  • Dosage Form
  • Sodium Alginate
  • Ethyl Cellulose
  • Hollow Microsphere

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 15.1

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Authors and Affiliations

  1. Department of Clinical Pharmacology, School of Pharmacy, Faculty of Health Sciences, Ben-Gurion University of the Negev, 653, Beer-Sheva, 84105, Israel

    Omri Wolk & Arik Dahan Ph.D.

Authors
  1. Omri Wolk
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  2. Arik Dahan Ph.D.
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Corresponding author

Correspondence to Arik Dahan Ph.D. .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Wolk, O., Dahan, A. (2014). Segmental-Dependent Drug Absorption and Delivery: The Stomach. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_15

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