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Focal Drug Delivery for Management of Oral Infections

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Focal Controlled Drug Delivery

Part of the book series: Advances in Delivery Science and Technology ((ADST))

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Abstract

Infection-related dental diseases, common in humans, include caries lesions, periodontal diseases, and endodontic infections. A variety of pharmaceutical dosage forms are used to prevent and treat oral diseases, most of them delivered focally and resulting in a local effect. The latest insights from the field of antimicrobial focal drug delivery has led to the development of various systems designed to effectively combat infections in the oral cavity, with minimal side effects. In the present chapter, the etiology of common oral diseases, characterization of infection–host interactions in oral disease, and classic dental treatment modalities are presented. We discuss the organization of oral microbes into biofilms and the intrinsic susceptibility characteristics of oral tissues, as well as the advantages of controlled focal drug delivery. The recent development of various novel technologies for the prevention, control, and treatment of oral infections are considered, including controlled focal delivery modalities.

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Authors and Affiliations

  1. Faculty of Dentistry, The Hebrew University—Hadassah, Jerusalem, Israel

    Nurit Beyth

  2. Department of Prosthodontics, Hebrew University—Hadassah School of Dental Medicine, 12272, Jerusalem, 91120, Israel

    Nurit Beyth

  3. Department of Prosthodontics, Hebrew University - Hadassah School of Dental Medicine, 12272, Jerusalem, 91120, Israel

    Orith Haramaty

  4. Department of Peridontics, Hebrew University-Hadassah School of Dental Medicine, 12272, Jerusalem, 91120, Israel

    David Polak

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  1. Nurit Beyth
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  2. Orith Haramaty
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  3. David Polak
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Correspondence to Nurit Beyth .

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Editors and Affiliations

  1. School of Pharmacy-Faculty of Medicine The Hebrew University of Jerusalem, Jerusalem, Israel

    Abraham J. Domb

  2. Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Balanagar, Hyderabad, Andhra Pradesh, India

    Wahid Khan

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Beyth, N., Haramaty, O., Polak, D. (2014). Focal Drug Delivery for Management of Oral Infections. In: Domb, A., Khan, W. (eds) Focal Controlled Drug Delivery. Advances in Delivery Science and Technology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4614-9434-8_14

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