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Applications of Biotechnology in Oncology pp 573–589Cite as

Role of MicroRNAs in Cancer

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Abstract

MicroRNAs (miRNAs), small and mostly noncoding RNA gene products, are molecules derived from larger segments of “precursor” RNA that are found in all diverse multicellular organisms. miRNAs are 21–25 nucleotide transcripts that repress gene function through interactions with target mRNAs. More detailed information is contained in a special report on microRNAs (Jain 2014).

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References

  • Bader AG, Brown D, Stoudemire J, Lammers P. Developing therapeutic microRNAs for cancer. Gene Ther 2011;18:1121-6.

    Article  CAS  Google Scholar 

  • Bar M, Wyman SK, Fritz BR, et al. MicroRNA discovery and profiling in human embryonic stem cells by deep sequencing of small RNA libraries. Stem Cells 2008;26:2496-505.

    Article  CAS  Google Scholar 

  • Broderick JA, Zamore PD. MicroRNA therapeutics. Gene Ther 2011;18:1104-10.

    Article  CAS  Google Scholar 

  • Bueno MJ, de Castro IP, Malumbres M. Control of cell proliferation pathways by microRNAs. Cell Cycle 2008;7:3143-8.

    Article  CAS  Google Scholar 

  • Calin GA, Sevignani C, Dumitru CD, et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. PNAS 2004;101:2999-3004.

    Article  CAS  Google Scholar 

  • Deng S, Lang J, Coukos G, Zhang L. Expression profile of microRNA in epithelial cancer: diagnosis, classification and prediction. Expert Opin Med Diagn 2009;3:25-36.

    Article  CAS  Google Scholar 

  • Dykxhoorn DM. MicroRNAs and Metastasis: Little RNAs Go a Long Way. Cancer Res 2010;70;6401-6.

    Article  CAS  Google Scholar 

  • Fabbri M, Ivan M, Cimmino A, et al. Regulatory mechanisms of microRNAs involvement in cancer. Exp Opin Biol Ther 2007;7:1009-19.

    Article  CAS  Google Scholar 

  • Feng Z, Zhang C, Wu R, Hu W. Tumor suppressor p53 meets microRNAs. J Mol Cell Biol 2011;3:44-50.

    Article  CAS  Google Scholar 

  • Hasemeier B, Christgen M, Kreipe HH, Lehmann U. Reliable microRNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology. BMC Biotechnology 2008;8:90.

    Article  Google Scholar 

  • Hayashita Y, Osada H, Tatematsu Y, et al. A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation. Cancer Res 2005;65:9628-32.

    Article  CAS  Google Scholar 

  • He L, Thomson M, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005a;435:828-33.

    Article  CAS  Google Scholar 

  • He H, Jazdzewski K, Li W, et al. The role of microRNA genes in papillary thyroid carcinoma. PNAS 2005b;102:19075-80.

    Article  CAS  Google Scholar 

  • Heo I, Joo C, Cho J, et al. Lin28 mediates the terminal uridylation of let-7 precursor MicroRNA. Mol Cell 2008;32:276-84.

    Article  CAS  Google Scholar 

  • Hurst DR, Edmonds MD, Welch DR. Metastamir: The Field of Metastasis-Regulatory microRNA Is Spreading. Cancer Res 2009;69:7495-8.

    Article  CAS  Google Scholar 

  • Hwang HW, Wentzel EA, Mendell JT. Cell-cell contact globally activates microRNA biogenesis. Proc Natl Acad Sci U S A 2009;106:7016-21.

    Article  CAS  Google Scholar 

  • Jain KK. Biomarkers of Cancer. In, Jain KK. Handbook of Biomarkers. Springer, New York, 2010:189-326.

    Chapter  Google Scholar 

  • Jain KK. MicroRNA: technologies, markets and companies. Jain PharmaBiotech Publications. Basel, Switzerland, 2014.

    Google Scholar 

  • Kulshreshtha R, Ferracin M, Negrini M, et al. Regulation of microRNA expression: the hypoxic component. Cell Cycle 2007;6:1426-31.

    Article  CAS  Google Scholar 

  • Lu J, Getz G, Miska EA, et al. MicroRNA expression profiles classify human cancers. Nature 2005;435:834-8.

    Google Scholar 

  • Lujambio A, Calin GA, Villanueva A, et al. A microRNA DNA methylation signature for human cancer metastasis. PNAS 2008;105:13556-61.

    Article  CAS  Google Scholar 

  • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007;449:682-8.

    Article  CAS  Google Scholar 

  • Mongroo PS, Rustgi AK. The role of the miR-200 family in epithelial-mesenchymal transition. Cancer Biol Ther 2010;10:219-22.

    Article  CAS  Google Scholar 

  • Pereira DM, Rodrigues PM, Borralho PM, Rodrigues CM. Delivering the promise of miRNA cancer therapeutics. Drug Discov Today 2013;18:282-9.

    Article  CAS  Google Scholar 

  • Pillai RS, Bhattacharyya SN, Artus CG, et al. Inhibition of translational initiation by Let-7 MicroRNA in human cells. Science 2005;309:1573-6.

    Article  CAS  Google Scholar 

  • Piskounova E, Viswanathan SR, Janas M, et al. Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J Biol Chem 2008;283(31):21310-4.

    Google Scholar 

  • Sassen S, Miska EA, Caldas C. MicroRNA: implications for cancer. Virchows Arch 2008;452:1-10.

    Article  CAS  Google Scholar 

  • Scaria V, Jadhav V. microRNAs in viral oncogenesis. Retrovirology 2007;4:82.

    Article  Google Scholar 

  • Schmittgen TD. miR-31: a master regulator of metastasis? Future Oncol 2010;6:17-20.

    Article  CAS  Google Scholar 

  • Spizzo R, Nicoloso MS, Calin GA. MicroRNAs as new biomarkers in oncology. Expert Opinion on Medical Diagnostics 2008;2:115-27.

    Article  CAS  Google Scholar 

  • Stenvang J, Silahtaroglu AN, Lindow M, et al. The utility of LNA in microRNA-based cancer diagnostics and therapeutics. Semin Cancer Biol 2008;18:89-102.

    Article  CAS  Google Scholar 

  • Tricoli JV, Jacobson JW. MicroRNA: Potential for Cancer Detection, Diagnosis, and Prognosis. Cancer Res 2007;67:4553-5.

    Article  CAS  Google Scholar 

  • Tsuda N, Kawano K, Efferson CL, Ioannides CG. Synthetic microRNA and double-stranded RNA targeting the 3′-untranslated region of HER-2/neu mRNA inhibit HER-2 protein expression in ovarian cancer cells. Int J Oncol 2005;27:1299-306.

    CAS  Google Scholar 

  • Valeri N, Gasparini P, Fabbri M, et al. Modulation of mismatch repair and genomic stability by miR-155. Proc Natl Acad Sci USA 2010;107:6982-7.

    Article  CAS  Google Scholar 

  • Varambally S, Cao Q, Mani RS, et al. Genomic Loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer. Science 2008;322:1695-9.

    Article  CAS  Google Scholar 

  • Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006;103:2257-61.

    Google Scholar 

  • Yang N, Coukos G, Zhang L. MicroRNA epigenetic alterations in human cancer: one step forward in diagnosis and treatment. Int J Cancer 2008;122:963-8.

    Article  CAS  Google Scholar 

  • Zhang L, Huang J, Yang N, et al. microRNAs exhibit high frequency genomic alterations in human cancer. PNAS 2006;103:9136-41.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Jain PharmaBiotech, Basel, Switzerland

    Kewal K. Jain MD, FRACS, FFPM

Authors
  1. Kewal K. Jain MD, FRACS, FFPM
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Jain, K.K. (2014). Role of MicroRNAs in Cancer. In: Applications of Biotechnology in Oncology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9245-0_13

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