Abstract
There are multiple factors involved in the causation of cancer, and both external and intrinsic events play a role in the malignant transformation of cells. An understanding of the biochemical abnormalities in tumor cells and the differences from normal cellular biology can lead to the development of effective, nontoxic, tumor-specific treatments.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bailey SM, Murnane JP. Telomeres, chromosome instability and cancer. Nucleic Acids Res 2006;34:2408-17.
Bangham AD, Standish MM, Watkin JC. Diffusion of univalent ions across the lamellae of swollen phospholipids. J Mol Biol 1965;13:238-52.
Bayever E, Iversen PL, Smith L, et al. Systemic human antisense therapy begins. Antisense Research & Development 1992;2:109-10.
Casorelli I, Bossa C, Bignami M. DNA damage and repair in human cancer: molecular mechanisms and contribution to therapy-related leukemias. Int J Environ Res Public Health 2012;9:2636-57.
Chandra D, Bratton SB, Person MD, et al. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell 2006;125:1333-46.
Decottignies A. Alternative end-joining mechanisms: a historical perspective. Front Genet 2013;4:48.
Douglas SJ, Davis SS, Illum L. Nanoparticles in drug delivery. Crit Rev Ther Drug Carrier Syst 1987;3:233-61.
Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971;285:1182-6.
Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011;144:646-74.
Knipscheer P, Räschle M, Smogorzewska A, et al. The Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair. Science 2009;326:1698-701.
Kohler G, Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity 1975. Biotechnology 1992;24:524-6.
Kulshreshtha R, Ferracin M, Wojcik SE, et al. A microRNA signature of hypoxia. Mol Cell Biol 2007;27:1859-67.
Laramore GE. The use of neutrons in cancer therapy: a historical perspective through the modern era. Semin Oncol 1997;24:672-85.
Ley TJ, Mardis ER, Ding L, et al. DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. Nature 2008;456:66-72.
Li H, Fan X, Houghton J. Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem 2007;101:805-15.
Li M, Xiong ZG. Ion channels as targets for cancer therapy. Int J Physiol Pathophysiol Pharmacol 2011;3:156-66.
Mathe G, Schwarzenberg L. Bone marrow transplantation (1958-1978): conditioning and graft-versus-host disease, indications in aplasias and leukemias. Pathol Biol (Paris) 1979;27:337-43.
Mittal V, Nolan DJ. Genomics and proteomics approaches in understanding tumor angiogenesis. Expert Rev Mol Diagn 2007;7:133-47.
Moore TL, Kupchik HZ, Marcon N, Zamcheck N. Carcinoembryonic antigen assay in cancer of the colon and pancreas and other digestive tract disorders. Am J Dig Dis 1971;16:1-7.
Mullis K, Faloona F, Scharf S, et al. Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harbor Symposium on Quantitative Biology 1986;51:263-73.
Papas RJ. Origins of cancer therapy. Yale J Biol Med 2001;74:391-8.
Rosenberg SA, Aebersold P, Cornetta K, et al. Gene transfer into humans -immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction. NEJM 1990;323:570-8.
Schwartz RS. Paul Ehrlich’s magic bullets. NEJM 2004;350:1079-80.
Siddiqa A, Cavazos DA, Marciniak RA. Targeting telomerase. Rejuvenation Res 2006;9:378-90.
Steinman RM, Cohn ZA. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med 1973;137:1142-62.
Thijssen V, Postel R, Brandwijk R, et al. Galectin-1 is essential in tumor angiogenesis and is a target for antiangiogenesis therapy. PNAS 2006;103:5975-80.
Thomas ED, Lochte HL Jr, et al. Intravenous infusion of bone marrow in patients receiving radiation and chemotherapy. N Engl J Med 1957;257:491-496.
Vecchiarelli-Federico LM, Cervi D, Haeri M, et al. Vascular Endothelial Growth Factor—A Positive and Negative Regulator of Tumor Growth. Cancer Res 2010;70;863-7.
Xie L, Duncan MB, Pahler J, et al. Counterbalancing angiogenic regulatory factors control the rate of cancer progression and survival in a stage-specific manner. Proc Natl Acad Sci U S A 2011;108:9939-44.
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Jain, K.K. (2014). Molecular Biology of Cancer. In: Applications of Biotechnology in Oncology. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4614-9245-0_1
Download citation
DOI: https://doi.org/10.1007/978-1-4614-9245-0_1
Published:
Publisher Name: Humana Press, New York, NY
Print ISBN: 978-1-4614-9244-3
Online ISBN: 978-1-4614-9245-0
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)