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Two-Component Signalling Systems of M. tuberculosis: Regulators of Pathogenicity and More

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Dynamic Models of Infectious Diseases

Abstract

Tuberculosis is one of the oldest infectious diseases known to mankind. It is cited in ancient texts by many interesting but dreadful names including “white plague,” “consumption,” and “Yakshma.” The disease is characterized by slow “wasting” of internal systems in the body, primarily respiratory and immune systems hence the name “consumption,” which literally means to consume or use from inside. Clinically, the disease manifestations include persistent, productive and bloody cough, breathlessness and chest pain in case of pulmonary infection. In almost 25 % of cases the infection manifests in extrapulmonary locations, such as bones, central nervous system, peripheral nervous system and genitourinary system. The systemic symptoms, which are manifested in all forms of tuberculosis irrespective of site of infection, include weight loss, chills, night sweat, loss of appetite and fever. The causative agent is disseminated by aerosol droplets released in the air by infected individuals by coughing, sneezing or even speaking. This form of the dissemination is very lethal as a very small bacillary dose is enough to elicit infection and the bacilli can stay viable in air for extended durations of time.

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Acknowledgements

Supported by financial aid from IISc (Indian Institute of Science); CSIR (Council for Scientific and Industrial Research, New Delhi) and Department of Biotechnology (DBT) to D.K.S. laboratory and a Junior Research Fellowship to R.A. from CSIR.

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Authors and Affiliations

  1. Department of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Sir CV Raman Avenue, Bangalore, 560012, India

    Ruchi Agrawal, Vignesh H. Narayan & Deepak Kumar Saini

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  1. Ruchi Agrawal
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  2. Vignesh H. Narayan
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  3. Deepak Kumar Saini
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Correspondence to Deepak Kumar Saini .

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  1. Foundation for Scientific Research and Technological Innovation, Hyderabad, Andhra Pradesh, India

    V. Sree Hari Rao

  2. University of New Mexico School of Medicine, Albuquerque, New Mexico, USA

    Ravi Durvasula

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Agrawal, R., Narayan, V.H., Saini, D.K. (2013). Two-Component Signalling Systems of M. tuberculosis: Regulators of Pathogenicity and More. In: Sree Hari Rao, V., Durvasula, R. (eds) Dynamic Models of Infectious Diseases. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9224-5_4

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