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Pregnancy of Unknown Viability

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Ultrasound Imaging in Reproductive Medicine

Abstract

Bleeding in early pregnancy complicates 15 % of all conceptions and accounts for nearly 2 % of all emergency department visits. Seventy to ninety percent of these pregnancies will progress normally. The remainder will either spontaneously abort or be an ectopic pregnancy. With advances in technology, the ability to detect pregnancy at earlier gestational age, either biochemically or sonographically, provides both diagnostic assistance and challenge to practitioners. One of the more clinically challenging scenarios is the patient with a positive pregnancy test who presents with uterine bleeding or pelvic pain and whose fetus cannot be located by ultrasound. An astute clinician must always have concern for a life-threatening ectopic pregnancy or miscarriage. When the situation is uncertain, the clinician must decide if the patient has signs and symptoms highly concerning for abnormal pregnancy. This is important to avoid erroneous treatments or counseling which could not only harm a viable fetus but also may lead to significant medical legal risk. The uncertainty of diagnosis and management is especially true when physicians from multiple disciplines with different skill sets converge in the emergency department. The goal of this chapter is to clarify for the practitioner the evaluation and treatment of early pregnancy of unknown viability or location.

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Abbreviations

β-hCG:

Beta subunit of human chorionic gonadotropin

FHR:

Fetal heart rate

FP:

Fetal pole

GS:

Gestational sac

hCG:

Human chorionic gonadotropin

IPUV:

Intrauterine pregnancy of unknown viability

PUL:

Pregnancy of unknown location

SAB:

Spontaneous abortion

YS:

Yolk sac

References

  1. Wittels KA, Pelletier AJ, Brown DFM, et al. United States emergency department visits for vaginal bleeding during early pregnancy, 1993–2003. Am J Obstet Gynecol. 2008;198:523.e1–6.

    Article  Google Scholar 

  2. American College of Obstetricians and Gynecologists. Medical management of ectopic pregnancy. ACOG practice bulletin no. 94. Obstet Gynecol. 2008;111:1479–85.

    Article  Google Scholar 

  3. Davies S, Byrn F, Cole L. Human chorionic gonadotropin testing for early pregnancy viability and complications. Clin Lab Med. 2003;23:257–64.

    Article  PubMed  Google Scholar 

  4. First week of development: ovulation to implantation. In: Sadler TW, editor. Langman’s medical embryology. 10th ed. Baltimore: Lippincott Williams & Wilkins; 2006. p. 31–43.

    Google Scholar 

  5. Second week of development: bilaminar germ disc. In: Sadler TW, editor. Langman’s medical embryology. 10th ed. Baltimore: Lippincott Williams & Wilkins; 2006. p. 46–53.

    Google Scholar 

  6. Romero R, Copel JA, Kadar N, Jeanty P, Decherney A, Hobbins J. Value of culdocentesis in the diagnosis of ectopic pregnancy. Obstet Gynecol. 1985;65(4):519–22.

    CAS  PubMed  Google Scholar 

  7. Kletzky OA, Rossman F, Bertolli SI, Platt LD, Mishell Jr DR. Dynamics of human chorionic gonadotropin, prolactin, and growth hormone in serum and amniotic fluid throughout normal human pregnancy. Am J Obstet Gynecol. 1985;151(7):878–84.

    Article  CAS  PubMed  Google Scholar 

  8. Keay SD, Vatish M, Karteris E, Hillhouse EW, Randeva HS. REVIEW: the role of β-hCG in reproductive medicine. BJOG. 2004;111:1218–28. doi:10.1111/j.1471-0528.2004.00412.x.

    Article  CAS  PubMed  Google Scholar 

  9. Braunstein GD, Rasor J, Hanser H, et al. Serum human chorionic gonadotropin levels throughout normal pregnancy. Am J Obstet Gynecol. 1976;126:678.

    CAS  PubMed  Google Scholar 

  10. Fritz MA, Guo SM. Doubling time of human chorionic gonadotropin (β-hCG) in early normal pregnancy: relationship to β-hCG concentration and gestational age. Fertil Steril. 1987;47(4):584.

    CAS  PubMed  Google Scholar 

  11. Kadar N, DeVore G, Romero R. Discriminatory β-hCG zone: its use in the sonographic evaluation for ectopic pregnancy. Obstet Gynecol. 1981;58(2):156–61.

    CAS  PubMed  Google Scholar 

  12. Barnhart KT, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W. Symptomatic patients with an early viable intrauterine pregnancy: HCG curves redefined. Obstet Gynecol. 2004;104:50–5.

    Article  PubMed  Google Scholar 

  13. Morse C, Sammel M, Shaunik A, Allen-Taylor L, Oberfoell N, Tackacs P, Chung K, Barnhart K. Performance of human chorionic gonadotropin curves in women at risk for ectopic pregnancy: exceptions to the rules. Fertil Steril. 2012;97(1):101–6.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Romero R, Kadar N, Jeanty P, Copel J, Chervenak F, DeCherney A, Hobbins J. Diagnosis of ectopic pregnancy: value of human chorionic gonadotropin zone. Obstet Gynecol. 1985;66(3):357–60.

    CAS  PubMed  Google Scholar 

  15. Barnhart KT, Katz I, Hummel A, Gracia CR. Presumed diagnosis of ectopic pregnancy. Obstet Gynecol. 2002;100(3):505–10.

    Article  PubMed  Google Scholar 

  16. Silva C, Sammel MD, Zhou L, Gracia C, Hummel AC, Barnhart K. Human chorionic gonadotropin profile for women with ectopic pregnancy. Obstet Gynecol. 2006;107(3):605–10.

    Article  CAS  PubMed  Google Scholar 

  17. Shepherd R, Patton P, Novy M, Burry K. Serial β-hCG measurements in the early detection of ectopic pregnancy. Obstet Gynecol. 1990;75(3):417–20.

    CAS  PubMed  Google Scholar 

  18. Condous G, Kirk E, Van Calster B, Van Huffel S, Timmerman D, Bourne T. Failing pregnancies of unknown location: a prospective evaluation of the human chorionic gonadotrophin ratio. BJOG. 2006;113:521–7.

    Article  CAS  PubMed  Google Scholar 

  19. Reid S, Condous G. Is there a need to definitively diagnose the location of a pregnancy of unknown location? The case for “no”. Fertil Steril. 2012;98(5):1085–90.

    Article  PubMed  Google Scholar 

  20. Cacciatore B, Stenman U, Ylostalo P. Diagnosis of ectopic pregnancy by vaginal ultrasonography in combination with a discriminatory serum β-hCG level of 1000 IU/1 (IRP). BJOG. 1990;97:904–8.

    Article  CAS  Google Scholar 

  21. Condous G, Kirk E, Lu S, VanHuffel S, Gevaert O, DeMoor B, DeSmet F, Timmerman D, Bourne T. Diagnostic accuracy of varying discriminatory zones for the prediction of ectopic pregnancy in women with a pregnancy of unknown location. Ultrasound Obstet Gynecol. 2005;26(7):770–5.

    Article  CAS  PubMed  Google Scholar 

  22. Mol B, Hajeniius PJ, Engelsbel S, Ankum W, VanderVeen F, Hemrika D, Bossuyt P. Serum human chorionic gonadotropin measurement in the diagnosis of ectopic pregnancy when transvaginal sonography is inconclusive. Fertil Steril. 1998;70(5):972–81.

    Article  CAS  PubMed  Google Scholar 

  23. Connolly AM, Ryan DH, Stuebe AM, Wolfe HM. Reevaluation of discriminatory and threshold levels for serum β-hCG in early pregnancy. Obstet Gynecol. 2013;121(1):65–70.

    CAS  PubMed  Google Scholar 

  24. American College of Radiology. ACR appropriateness criteria for first trimester bleeding. 2012. http://www.acr.org/~/media/ACR/Documents/AppCriteria/Diagnostic/SecondAndThirdTrimesterBleeding.pdf. Last accessed on 4 Dec 2012.

  25. AIUM practice guideline for the performance of obstetric ultrasound. 2007. http://www.aium.org/resources/guidelines/obstetric.pdf. Last accessed on 4 Dec 2012.

  26. Seeber B. What serial hCG can tell you, and cannot tell you, about an early pregnancy. Fertil Steril. 2012;98(5):1074–7.

    Article  CAS  PubMed  Google Scholar 

  27. Hoover KW, Tao G, Kent CK. Trends in the diagnosis and treatment of ectopic pregnancy in the United States. Obstet Gynecol. 2010;115:495–502.

    Article  PubMed  Google Scholar 

  28. Pexsters A, Luts J, Van Schoubroeck D, Bottomley C, Van Calster B, Van Huffel S, Abdallah Y, D’Hooghe T, Lees C, Timmerman D, Bourne T. Clinical implications of intra- and interobserver reproducibility of transvaginal sonographic measurement of gestational sac and crown–rump length at 6–9 weeks’ gestation. Ultrasound Obstet Gynecol. 2011;38:510–5.

    Article  CAS  PubMed  Google Scholar 

  29. Goldstein S, Snyder JR, Watson C, Danon M. Very early pregnancy detection with endovaginal ultrasound. Obstet Gynecol. 1988;72(2):200–4.

    CAS  PubMed  Google Scholar 

  30. American College of Obstetricians and Gynecologists. Ultrasonography in pregnancy. ACOG practice bulletin no. 101. Obstet Gynecol. 2009;113:451–61.

    Google Scholar 

  31. Abdallah Y, Daemen A, Guha S, Syed S, Naji O, Pexsters A, Kirk E, Stalder C, Gould D, Ahmed S, Bottomley C, Timmerman D, Bourne T. Gestational sac and embryonic growth are not useful as criteria to define miscarriage: a multicenter observational study. Ultrasound Obstet Gynecol. 2011;38:503–9.

    Article  CAS  PubMed  Google Scholar 

  32. Abdallah Y, Daemen A, Kirk E, Pexsters A, Naji O, Stalder C, Gould D, Ahmed S, Guha S, Syed S, Bottomley C, Timmerman D, Bourne T. Limitations of current definitions of miscarriage using mean gestational sac diameter and crown–rump length measurements: a multicenter observational study. Ultrasound Obstet Gynecol. 2011;38:497–502.

    Article  CAS  PubMed  Google Scholar 

  33. Society Obstetricians Gynecologists of Canada. Ultrasound evaluation of first trimester pregnancy complications. SOGC clinical practice guidelines. J Obstet Gynaecol Can. 2005;161:581–585.

    Google Scholar 

  34. Jauniaux E, Johns J, Burton J. The role of ultrasound imaging in diagnosing and investigating early pregnancy failure. Ultrasound Obstet Gynecol. 2005;25:613–24.

    Article  CAS  PubMed  Google Scholar 

  35. VanMello NM, Mol F, Ankum W, Mol BW, van der Veen F, Hajenius PJ. Ectopic pregnancy: how the diagnostic and therapeutic management has changed. Fertil Steril. 2012;98(5):1066–73.

    Article  Google Scholar 

  36. Doubliet PM, Benson CB. First, do no harm…to early pregnancies. J Ultrasound Med. 2010;29:685–9.

    Google Scholar 

  37. Branch DW, Gibson M, Silber R. Clinical practice. Recurrent miscarriage. N Engl J Med. 2010;363(18):1740–7.

    Article  CAS  PubMed  Google Scholar 

  38. Hatley W, Chase J, Campbell S. Establishing the death of an embryo by ultrasound: report of a public inquiry with recommendations. Ultrasound Obstet Gynecol. 1995;5:353–7.

    Article  Google Scholar 

  39. Chang HJ, Chang SS. Ectopic pregnancy after assisted reproductive technology: what are the risk factors? Curr Opin Obstet Gynecol. 2010;22:202–7.

    Article  PubMed  Google Scholar 

  40. Banerjee S, Aslam N, Zosmer N, Woelfer B, Jrkovic D. The expectant management of early pregnancy of unknown location. Ultrasound Obstet Gynecol. 1999;14:231–6.

    Article  CAS  PubMed  Google Scholar 

  41. Barnhart K, van Mello NM, et al. Pregnancy of unknown location: a consensus statement of nomenclature, definitions and outcome. Fertil Steril. 2011;95(3):857–66.

    Article  PubMed Central  PubMed  Google Scholar 

  42. Condous G, Okaro E, Bourne T. The conservative management of early pregnancy complications: a review of the literature. Ultrasound Obstet Gynecol. 2003;22:420–30.

    Article  CAS  PubMed  Google Scholar 

  43. Rubal L, Chung K. Do you need to definitively diagnose the location of a pregnancy of unknown location? The case for “yes”. Fertil Steril. 2012;98(5):1078–84.

    Article  PubMed  Google Scholar 

  44. Barnhart K. Early pregnancy failure: beware of the pitfalls of modern management. Fertil Steril. 2012;98(5):1061–5.

    Article  PubMed Central  PubMed  Google Scholar 

  45. Jeve Y, Rana R, Bhide A, Thangaratinam S. Accuracy of first-trimester ultrasound in the diagnosis of early embryonic demise: a systematic review. Ultrasound Obstet Gynecol. 2011;38:489–96. doi:10.1002/uog.10108.

    Article  CAS  PubMed  Google Scholar 

  46. Royal College of Obstetricians and Gynaecologists. The management of early pregnancy loss. Guideline no. 21. London: RCOG; 2006.

    Google Scholar 

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Correspondence to Steven L. Warsof MD .

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Myer, E.N.B., Arrington, J., Warsof, S.L. (2014). Pregnancy of Unknown Viability. In: Stadtmauer, L., Tur-Kaspa, I. (eds) Ultrasound Imaging in Reproductive Medicine. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9182-8_24

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  • DOI: https://doi.org/10.1007/978-1-4614-9182-8_24

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