Abstract
This chapter focuses on the psychosocial evaluation, informed consent process, and follow-up post donation of unrelated organ donors, defined as individuals who are neither biologically related nor closely emotionally related to the transplant recipient. The impetus for considering unrelated donors is the growth in number and types of unrelated donors in the US in the past 20 years. In addition, there has been an expansion in the range of opportunities for unrelated donors to donate, including participation in kidney exchange programs. We consider the characteristics of unrelated donors that heighten the concerns of donor programs about donor psychosocial risks, and elements of the psychosocial screening and evaluation that require close scrutiny, including, for example, donors’ motives for donation, and their understanding and expectations about the donation process. We highlight elements that can complicate the informed consent process, including unique risks of coercion in unrelated donors, differences in the benefit-to-risk ratio for donation by unrelated vs. related donors, and special issues regarding confidentiality. We review evidence on post-donation outcomes in unrelated donors and issues that warrant consideration in follow-up with these individuals.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
U.S. Organ Procurement and Transplantation Network and the Scientific Registry of Transplant Recipients. Living donor transplants by donor relation table for U.S. Transplants performed January 1, 1988-January 31, 2013, kidney, http://www.optn.transplant.hrsa.gov. Department of Health and Human Services, Health Resources and Services Administration, Healthcare Systems Bureau, Division of Transplantation, Rockville, MD; United Network for Organ Sharing, Richmond, VA; Last accessed 21 April 2013.
Spital A. Evolution of attitudes at U.S. transplant centers toward kidney donation by friends and altruistic strangers. Transplantation. 2000;69:1728–31.
Spital A. Public attitudes toward kidney donation by friends and altruistic strangers in the United States. Transplantation. 2001;71(8):1061–4.
Rodrigue JR, Pavlakis M, Danovitch GM, Johnson SR, Karp SJ, Khwaja K, et al. Evaluating living kidney donors: relationship types, psychosocial criteria, and consent processes at US transplant programs. Am J Transplant. 2007;7:2326–32.
Terasaki PI, Cecka JM, Gjertson DW, Takemoto S. High survival rates of kidney transplants from spousal and living unrelated donors. N Engl J Med. 1995;333(6):333–6.
Lee SG. Living-donor liver transplantation in adults. Br Med Bull. 2010;94:33–48.
Dew MA, Jacobs C, Jowsey SG, Hanto R, Miller C, Delmonico FL. Guidelines for the psychosocial evaluation of living unrelated kidney donors in the United States. Am J Transplant. 2007;7:1047–54.
Dew MA, Jacobs CL, Jowsey SG, Hanto R, Miller C, Delmonico FL. Psychosocial evaluation of living unrelated kidney donors in the United States: Summary of guidelines from a consensus conference. In: Weimar W, Bos MA, Busschbach JJ, Editors. Organ transplantation: ethical, legal and psychological aspects. Towards a common European policy. Lengerich: Pabst Science Publishers; 2008. pp. 208–215.
DiMartini AF, Sotelo JL, Dew MA. Organ transplantation. In: Levenson JL (Editor). The American Psychiatric Publishing textbook of psychosomatic medicine: Psychiatric care of the medically ill. 2nd ed. Washington DC: American Psychiatric Publishing; 2010. pp. 725–58.
DiMartini A, Dew MA, Crone C. Organ transplantation. In: Sadock BJ, Sadock VA, Ruiz P, Editors. Kaplan and Sadock’s comprehensive textbook of psychiatry, 9th ed. Vol. 2. Philadelphia: Lippincott Williams & Wilkins; 2009. pp. 2441–56.
Jowsey SG, Schneekloth TD. Psychosocial factors in living organ donation: clinical and ethical challenges. Transplant Rev. 2008;22(3):192–5.
Olbrisch ME, Benedict SM, Haller DL, Levenson JL. Psychosocial assessment of living organ donors: clinical and ethical considerations. Prog Transplant. 2001;11:40–9.
Fisher MS. Psychosocial evaluation interview protocol for living related and living unrelated kidney donors. Soc Work Health Care. 2003;38:39–61.
Leo RL, Smith BA, Mori DL. Guidelines for conducting a psychiatric evaluation of the unrelated kidney donor. Psychosomatics. 2003;44:452–60.
Schroder NM, McDonald LA, Etringer G, Snyders M. Consideration of psychosocial factors in the evaluation of living donors. Prog Transplant. 2008;18:41–9.
Organ Procurement and Transplantation Network, Policy 12, Living donation. http://optn.transplant.hrsa.gov/policiesandbylaws2/policies/pdfs/policy_172.pdf. Last accessed 21 April 2013.
Organ Procurement and Transplantation Network. Living kidney donor psychosocial evaluation checklist. http://optn.transplant.hrsa.gov/news/newsDetail.asp?id=1590. Last accessed 21 April 2013.
Halbfinger DM. 44 charged by U.S. in New Jersey corruption sweep. New York Times. 2009 July 23. http://www.nytimes.com/2009/07/24/nyregion/24jersey.html?_r=0. Last accessed 21 April 2013.
Associated Press. Guilty pleas to kidney-selling charges. New York Times. 2011 October 27. http://www.nytimes.com/2011/10/27/nyregion/guilty-plea-to-kidney-selling-charges.html. Last accessed 21 April 2013.
Satel S. An internet lifetime: in search of a kidney. New York Times. 2005 November 22. http://www.sallysatelmd.com/html/a-nytimes19.html. Last accessed 21 April 2013.
Goyal M, Mehta RL, Schneiderman LJ, Schgal AR. Economic and health consequences of selling a kidney in India. JAMA. 2002;288:1589–93.
Zargooshi J. Quality of life of Iranian kidney “donors.” J Urol. 2001;166:1790–9.
Patel SR, Chadha P, Papalois V. Expanding the live kidney donor pool: ethical considerations regarding altruistic donors, paired and pooled programs. Exper Clinic Transplant. 2011;9(3):181–6.
Mazaris E, Papalois VE. Ethical issues in living donor kidney transplantation. Exper Clinic Transplant. 2006;4(2):485–97.
Ratner LE, Rana A, Ratner RE, Ernst V, Kelly J, Kornfeld D, et al. The altruistic unbalanced paired kidney exchange: proof of concept and survey of potential donor and recipient attitudes. Transplantation. 2010;89:15–22.
National Kidney Registry. Living donors. http://kidneyregistry.org/living_donors.php. Last accessed 21 April 2013.
Menon P. Rick Ruzzamenti’s donation of kidney to stranger sets off the worlds’ longest kidney transplant chain. Cure Talk. 2012 February 24. http://trialx.com/curetalk/2012/02/rick-ruzzamenti%e2%80%98s-donation-of-kidney-to-stranger-sets-off-the-worlds%e2%80%99-longest-kidney-transplant-chain/. Last accessed 21 April 2013.
Linked for life: The incredible story of kidney transplant Chain 124. Everyday Health. 2012 February 21. http://www.everydayhealth.com/healthy-living/0221/linked-for-life-the-incredible-story-of-kidney-transplant-chain-124.aspx. Last accessed 21 April 2013.
Woodle ES, Daller JA, Aeder M, Shapiro R, Sandholm T, Casingal V, et al. Ethical considerations for participation of nondirected living donors in kidney exchange programs. Am J Transplant. 2010;10(6):1460–7.
Sack K. 60 lives, 30 kidneys, all linked. New York Times. 2012 February 18. http://www.nytimes.com/2012/02/19/health/lives-forever-linked-through-kidney-transplant-chain-124.html. Last accessed 21 April 2013.
Rodrigue JR, Schutzer ME, Paek M, Morrissey P. Altruistic kidney donation to a stranger: psychosocial and functional outcomes at two US transplant centers. Transplantation. 2011;91:772–8.
Dew MA, Jacobs CL. Psychosocial and socioeconomic issues facing the living kidney donor. Adv Chron Kidney Dis. 2012;19(4):237–43.
Massey EK, Kranenburg LW, Zuidema WC, Hak G, Erdman RA, Hilhorst M, et al. Encouraging psychological outcomes after altruistic donation to a stranger. Am J Transplant. 2010;10:1445–52.
Kranenburg L, Zuidema W, Vanderkroft P, Duivenvoorden H, Weimar W, Passchier J, et al. The implementation of a kidney exchange program does not induce a need for additional psychosocial support. Transpl Int. 2007;20:432–9.
Lentine KL, Schnitzler MA, Xiao H, Axelrod D, Davis CL, McCabe M. Depression diagnoses after living kidney donation: linking U.S. registry data and administrative claims. Transplantation. 2012;94(1):77–83.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2014 Springer Science+Business Media New York
About this chapter
Cite this chapter
Dew, M., Boneysteele, G., DiMartini, A. (2014). Unrelated Donors. In: STEEL, J. (eds) Living Donor Advocacy. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9143-9_11
Download citation
DOI: https://doi.org/10.1007/978-1-4614-9143-9_11
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4614-9142-2
Online ISBN: 978-1-4614-9143-9
eBook Packages: MedicineMedicine (R0)