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Microdialysis

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Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Part of the book series: Cancer Drug Discovery and Development ((CDD&D))

Abstract

Limited tumor penetration could be a contributing factor to treatment of solid tumors when chemotherapy is administered systemically. Microdialysis is a technique utilized to evaluate tumor extracellular fluid disposition of anticancer agents and factors affecting delivery and removal of anticancer agents. Microdialysis utility has been demonstrated when evaluating the disposition of carrier-mediated agents (e.g., liposomes and PEG conjugates), gene therapy, and antisense oligonucleotides, and angiogenesis inhibitors. Future potential for microdialysis includes therapeutic drug monitoring and assessment of surrogate markers for response and toxicity. This chapter will discuss the advantages of microdialysis, the methodology and study design, and application to preclinical and clinical pharmacokinetic and pharmacodynamic studies.

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References

  1. Grever MR, Chabner BA (1997) Cancer drug development. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, PA, p 385

    Google Scholar 

  2. Jain RK (1996) Delivery of molecular medicine to solid tumors. Science 271:1079

    Article  CAS  PubMed  Google Scholar 

  3. Zamboni WC, Houghton PJ, Hulstein JL, Kirstein M, Walsh J, Cheshire PJ, Hanna SK, Danks MK, Stewart CF (1999) Relationship between tumor extracellular fluid exposure to topotecan and response in human neuroblastoma xenografts and cell lines. Cancer Chemother Pharmacol 43:269–276

    Article  CAS  PubMed  Google Scholar 

  4. Balch CM, Reintgen DS, Kirkwood JM et al (1997) Cutaneous melanoma. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer: principles and practice of oncology, 5th edn. Lippincott-Raven, Philadelphia, PA, p 1947

    Google Scholar 

  5. Muller M, Mader RM, Steiner B, Steger GG, Jansen B, Gnant M, Helbich T, Jakesz R, Eichler HG, Blochl-Daum B (1997) 5-Fluorouracil kinetics in the interstitial tumor space: clinical response in breast cancer patients. Cancer Res 57:2598

    CAS  PubMed  Google Scholar 

  6. Blochl-Daum B, Muller M, Meisinger V, Eichler HG, Fassolt A, Pehamberger H (1996) Measurement of extracellular fluid carboplatin kinetics in melanoma metastases with microdialysis. Br J Cancer 73:920

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  7. Brunner M, Muller M (2002) Microdialysis: an in vivo approach for measuring drug delivery in oncology. Eur J Clin Pharmacol 58(4):227–234

    Article  CAS  PubMed  Google Scholar 

  8. Zamboni WC, Gervais AC, Schellen JHM, Delauter BJ, Egorin MJ, Zuhowski EG, Pluim D, Hamburger DR, Working PK, Colbern G, Eiseman JL (2000) Disposition of platinum (Pt) in B16 murine melanoma tumors after administration of cisplatin & pegylated liposomal-cisplatin formulations (SPI-077 & SPI-077 B103). In: Proceedings of 11th NCI-EORTC-AACR Symposium on New Drugs in Cancer Therapy, November 2000 [Abstract #132]

    Google Scholar 

  9. Gelmon KA, Kisenhauer EA, Harris AL, Ratain MJ, Workman P (1999) Anticancer agents targeting signaling molecules and cancer cell environment: challenges for drug development? J Natl Cancer Inst 91:1281–1287

    Article  CAS  PubMed  Google Scholar 

  10. Zamboni WC, Gajjar AJ, Mandrell TD, Einhaus SL, Danks MK, Rogers WP, Heideman RL, Houghton PJ, Stewart CF (1998) A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuroaxis in the nonhuman primate model: implications for treatment of children with metastatic medulloblastoma. Clin Cancer Res 4(10):2537–2544

    CAS  PubMed  Google Scholar 

  11. Boucher Y, Jain RK (1992) Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implication for vascular collapse. Cancer Res 52:5110

    CAS  PubMed  Google Scholar 

  12. Zamboni WC, Gervias AC, Egorin MJ, Schellens JHM, Hamburger DR, Delauter BJ, Grim A, Zuhowski EG, Joseph E, Pluim D, Potter DM, Eiseman JL (2002) Inter- and intratumoral disposition of platinum in solid tumors after administration of cisplatin. Clin Cancer Res 8:2992–2999

    CAS  PubMed  Google Scholar 

  13. Muller M, Brunner M, Schmid R, Mader RM, Bockenhelmer J, Steger GG, Steiner B, Eichler HG, Blochl-Daum B (1998) Interstitial methotrexate kinetics in primary breast cancer lesions. Cancer Res 58:2982–2985

    CAS  PubMed  Google Scholar 

  14. Ekstrom PO, Giercksky KE, Andersen A, Bruland OS, Slordal L (1997) Intratumoral differences in methotrexate levels within human osteosarcoma xenografts studied by microdialysis. Life Sci 61(19):PL275–PL280

    Article  CAS  PubMed  Google Scholar 

  15. Ekstrom PO, Andersen A, Warren DJ, Giercksky KE, Slordal L (1996) Determination of extracellular methotrexate tissue levels by microdialysis in a rat model. Cancer Chemother Pharmacol 37(5):294–400

    Article  Google Scholar 

  16. Presant CA, Wolf W, Waluch V, Wiseman C, Kennedy P, Blayney D, Brechner R (1994) Association of intratumoral pharmacokinetics of fluorouracil with clinical response. Lancet 343:1184–1187

    Article  CAS  PubMed  Google Scholar 

  17. Front D, Isreal O, Iosilevsky G, Even-Sapir E, Frenkel A, Peleg H, Steiner M, Kuten A, Kolodny GM (1987) Human lung tumors: SPECT quantitation of differences in Co-57 bleomycin uptake. Radiology 165:129–133

    CAS  PubMed  Google Scholar 

  18. Fishman AJ, Alpert NM, Babich JW, Rubin RH (1997) The role of positron emission tomography in pharmacokinetic analysis. Drug Metab Rev 29:923–956

    Article  Google Scholar 

  19. Muller M, Schmid R, Georgopoulos A, Buxbaum A, Wasicek C, Eichler HG (1995) Application of microdialysis to clinical pharmacokinetics in humans. Clin Pharmacol Ther 57:371

    Article  CAS  PubMed  Google Scholar 

  20. Johansen MJ, Newman RA, Madden T (1997) The use of microdialysis in pharmacokinetics and pharmacodynamics. Pharmacotherapy 17:464

    CAS  PubMed  Google Scholar 

  21. Kehr J (1993) A survey on quantitation microdialysis: theoretical models and practical limitations. J Neurosci Methods 48:251

    Article  CAS  PubMed  Google Scholar 

  22. Mader RM, Schrolnberger C, Rizovski B, Brunner M et al (2003) Penetration of capecitabine and its metabolites into malignant and healthy tissues of patients with advanced breast cancer. Br J Cancer 88:782–787

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Hunz M, Jetter A, Pantke E et al (2007) Plasma and tissue pharmacokinetics of epirubicin and paclitaxel in patients receiving neoadjuvant chemotherapy for locally advanced primary breast cancer. Clin Pharmacol Ther 81:659–668

    Article  CAS  PubMed  Google Scholar 

  24. Inge RH, Konings M, Frederike K et al (2009) Application of prolonged microdialysis sampling in carboplatin-treated cancer patients. Cancer Chemother Pharmacol 3:509–516

    Google Scholar 

  25. Sandberg C, Halldin CB, Ericson MB et al (2008) Bioavailability of aminolaevulinic acid and methylaminolaevulinate in basal cell carcinomas: a perfusion study using microdialysis in vivo. Br J Dermatol 59:1170–1176

    Google Scholar 

  26. Blakeley JO, Olson J, Grossman SA et al (2009) Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. J Neurooncol 91:51–58

    Article  CAS  PubMed  Google Scholar 

  27. Tegeder I, Brautigam L, Seegal M et al (2003) Cisplatin tumor concentrations after intra-arterial cisplatin infusion or embolization in patients with oral cancer. Clin Pharmacol Ther 73:417–426

    Article  CAS  PubMed  Google Scholar 

  28. Leggas M, Welden J, Waters CM et al (2004) Microbore HPLC method with online microdialysis for measurement of topotecan lactone and carboxylate in murine CSF. J Pharm Sci 93:2284–2295

    Article  CAS  PubMed  Google Scholar 

  29. Ettinger SN, Poellmann CC, Wisniewski NA, Gaskin AA, Shoemaker JS, Poulson JM, Dewhirst MW, Klitzman B (2001) Urea as a recovery marker for quantitative assessment of tumor interstitial solutes with microdialysis. Cancer Res 61(21):7964–7970

    CAS  PubMed  Google Scholar 

  30. Ekstrom PO, Andersen A, Saeter G, Giercksky KE, Slordal L (1997) Continuous intratumoral microdialysis during high-dose methotrexate therapy in a patient with malignant fibrous histiocytoma of the femur; a case report. Cancer Chemother Pharmacol 39(3):267–272

    CAS  PubMed  Google Scholar 

  31. Thompson JF, Siebert GA, Anissimov YG, Simthers BM, Doubrovsky A, Anderson CD, Roberts MS (2001) Microdialysis and response during regional chemotherapy by isolated limb infusion of melphalan for limb malignancies. Br J Cancer 85(2):157–165

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Conley BA, Ramsland TS, Sentz DL, Wu S, Rosen DM, Wollman M, Eiseman JL (1999) Antitumor activity, distribution, and metabolism of 13-cis-retinoic acid as a single agent or in combination with tamoxifen in established human MCF-7 xenografts in mice. Cancer Chemother Pharmacol 43:183–197

    Article  CAS  PubMed  Google Scholar 

  33. Bungay PM, Morrison PF, Dedrick RL (1990) Steady-state theory for quantitative microdialysis of solutes and water in vivo and in vitro. Life Sci 46:105–119

    Article  CAS  PubMed  Google Scholar 

  34. LeQuellec A, Dupin S, Genissel P, Saivin S, Marchand B, Houin G (1995) Microdialysis probes calibration: gradient and tissue dependent changes in no net flux and reverse dialysis methods. J Pharmacol Toxicol Methods 33:11–16

    Article  CAS  Google Scholar 

  35. Fox E, Bungay PM, Bacher J, McGully CL, Dedrick RL, Balis FM (2002) Zidovudine concentration in brain extracellular fluid measured by microdialysis: steady-state and transient results in rhesus monkey. J Pharmacol Exp Ther 361:1003–1011

    Article  Google Scholar 

  36. Zamboni WC, Bowman LC, Tan M, Santana VM, Houghton PJ, Meyer WH, Pratt CB, Heideman RL, Gajjar AJ, Pappo AS, Stewart CF (1999) Interpatient variability in bioavailability of the intravenous formulation of topotecan given orally to children with recurrent solid tumors. Cancer Chemother Pharmacol 43:454–460

    Article  CAS  PubMed  Google Scholar 

  37. Furman WL, Stewart CF, Poquette CA, Pratt CB, Santana VM, Zamboni WC, Bowman LC, Ma MK, Hoffer FA, Meyer WH, Pappo AS, Walter M, Houghton PJ (1999) Direct translation of protracted irinotecan schedule from a xenograft model to a phase I trial in children. J Clin Oncol 17:1815–1824

    CAS  PubMed  Google Scholar 

  38. Egorin MJ, Van Echo DA, Tipping SJ, Olman EA, Whitacre MY, Thompson BW, Aisner J (1984) Pharmacokinetics and dosage reduction of cis-diammine(1, 1-cyclobutanedicarboxylato) platinum in patients with impaired renal function. Cancer Res 44:5432–5438

    CAS  PubMed  Google Scholar 

  39. Erkmen K, Egorin MJ, Reyno LM, Morgan R Jr, Doroshow JH (1995) Effects of storage on the binding of carboplatin to plasma protein. Cancer Chemother Pharmacol 35:254–256

    Article  CAS  PubMed  Google Scholar 

  40. Gerin C (2002) Behavioral improvement and dopamine release in a Parkinsonian rat model. Neurosci Lett 330(1):5

    Article  CAS  PubMed  Google Scholar 

  41. Mark GP, Finn DA (2002) The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines. Alcohol Clin Exp Res 26(8):1141–1152

    CAS  PubMed  Google Scholar 

  42. Jones DA, Ros J, Landolt H, Fillenz M, Boutelle MG (2000) Dynamic changes in glucose and lactate in the cortex of the freely moving rat monitored using microdialysis. J Neurochem 75:1703–1708

    Article  CAS  PubMed  Google Scholar 

  43. Zauner A, Doppenber E, Soukup J, Menzel M, Young HF, Bullock R (1998) Extended neuromonitoring: new therapeutic opportunities? Neurol Res 20:S85–S90

    PubMed  Google Scholar 

  44. Tolias CM, Richards DA, Bowery NG, Sgouros S (2002) Extracellular glutamate in the brains of children with severe head injuries: a pilot microdialysis study. Childs Nerv Syst 18(8):368–374

    PubMed  Google Scholar 

  45. Kitano M, Sakamoto H, Kshaunish D et al (2010) EUS-guided in vivo microdialysis of the pancreas: a novel technique with potential diagnostic and therapeutic application. Gastrointest Endosc 71:176–179

    Article  PubMed  Google Scholar 

  46. Zamboni WC, Stewart CF, Thompson J, Santana V, Cheshire PJ, Richmond LB, Lui X, Houghton JA, Houghton PJ (1998) The relationship between topotecan systemic exposure and tumor response in human neuroblastoma xenografts. J Natl Cancer Inst 90:505–511

    Article  CAS  PubMed  Google Scholar 

  47. Takamitsu O, Tjuvajev JG, Miyagawa T, Sasajima T, Joshi A, Joshi R, Finn R, Claffey KP, Blasberg RG (1998) Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts. Cancer Res 58:4185–4192

    Google Scholar 

  48. Devineni D, Klein-Szanto A, Gallo JM (1996) Uptake of temozolomide in a rat glioma model in the presence and absence of the angiogenesis inhibitor TNP-470. Cancer Res 56(9):1983–1987

    CAS  PubMed  Google Scholar 

  49. Ma J, Pulfer S, Li S, Chu J, Reed K, Gallo JM (2001) Pharmacodynamic-mediated reduction of temozolomide tumor concentrations by the angiogenesis inhibitor TNP-470. Cancer Res 61(14):5491–5498

    CAS  PubMed  Google Scholar 

  50. Harrington KJ, Lewanski CR, Northcote AD, Whittaker J, Welbanck H, Peters AM et al (2001) Phase I-II study of pegylated liposomal cisplatin (SPI-77) in patients with inoperable head and neck cancer. Ann Oncol 12:493–496

    Article  CAS  PubMed  Google Scholar 

  51. Newman MS, Colbern GT, Working PK et al (1999) Comparative pharmacokinetics, tissue distribution, and therapeutic effectiveness of cisplatin encapsulated in long-circulating, pegylated liposomes (SPI-077) in tumor bearing mice. Cancer Chemother Pharmacol 43:1–7

    Article  CAS  PubMed  Google Scholar 

  52. Allen TM, Stuart DD (1999) Liposomal pharmacokinetics. Classical, sterically-stabilized, cationic liposomes and immunoliposomes. In: Janoff AS (ed) Liposomes: rational design. Marcel Dekker, New York, NY, pp 63–87

    Google Scholar 

  53. Woodle MC, Lasic DD (1992) Sterically stabilized liposomes. Biochem Biophys Acta 1113:171–199

    CAS  PubMed  Google Scholar 

  54. Harrington KJ, Rowlinson-Busza G, Synigos KN et al (2000) Biodistribution and pharmacokinetics of 111-In-DTPA-labeled pegylated liposomes in a human tumor xenograft model: implications for novel targeting strategies. Br J Cancer 83(2):232–238

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  55. Muggia FM, Hainsworth JD, Hainsworth JD, Jeffers S et al (1997) Phase II study of liposomal doxorubicin in refractory ovarian cancer: antitumor activity and toxicity modification by liposomal encapsulation. J Clin Oncol 15:987–993

    CAS  PubMed  Google Scholar 

  56. Stewart JSW, Jablonowski H, Goebel F-D et al (1998) Randomized comparative trial of pegylated liposomal doxorubicin versus bleomycin and vincristine in the treatment of AIDS-related Kaposi’s sarcoma. International Doxorubicin Study Group. J Clin Oncol 16:683–691

    CAS  PubMed  Google Scholar 

  57. Harrington KJ, Monhammadtaghi S, Uster PS et al (2001) Effective targeting of solid tumors in patients with locally advanced cancers by radiolabeled pegylated liposomes. Clin Cancer Res 7(2):223–225

    Google Scholar 

  58. Harrington KJ, Rowlinson-Busza G, Synigos KN et al (2000) Influence of tumor size on uptake of 111-In-DTPA-labeled pegylated liposomes in a human tumor xenograft model. Br J Cancer 83(5):684–688

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  59. DeMario MD, Vogelzang NJ, Janisch L, Tonda M, Amantea MA, Pendyala L et al (1998) A Phase I study of liposome-formulated cisplatin (SPI-077) given every 3 weeks in patients with advanced cancer. Proc Am Soc Clin Oncol 17:883

    Google Scholar 

  60. Veal GJ, Griffin MJ, Price E, Parry A, Dick GS, Little MA et al (2001) A phase I study in paediatric patients to evaluate the safety and pharmacokinetics of SPI-77, a liposome encapsulated formulation of cisplatin. Br J Cancer 84:1029–1035

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  61. Pluim D, Maliepaard M, van Waardenburg RC, Beijnen JH, Schellens JHM (1999) 32P-postlabeling assay for the quantitation of the major platinum-DNA adducts. Anal Biochem 274(1):30–38

    Article  Google Scholar 

  62. Zamboni WC, Stychor S, Joseph R et al (2007) Plasma, tumor, and tissue disposition of STEALTH liposomal CKD-602 (S-CKD602) and nonliposomal CKD-602 in mice bearing A375 human melanoma xenografts. Clin Cancer Res 13:7217–7223

    Article  CAS  PubMed  Google Scholar 

  63. Mathijssen RH, de Jong FA, Loos WJ, van der Bol JM, Verweij J, Sparreboom A (2007) Flat-fixed dosing versus body surface area based dosing of anticancer drugs in adults: does it make a difference? Oncologist 12(8):913–923

    Article  PubMed  Google Scholar 

  64. Sparreboom A (2005) BSA-based dosing and alternative approaches. Clin Adv Hematol Oncol 3(6):448–450, No abstract available

    PubMed  Google Scholar 

  65. Hollenstein UM, Brunner M, Schmid R, Muller M (2001) Soft tissue concentrations of ciprofloxacin in obese and lean subjects following weight-adjusted dosing. Int J Obes (Lond) 25:354–358

    Article  CAS  Google Scholar 

  66. Joukhadar C, Derendorf H, Muller M (2001) Microdialysis: a novel tool for clinical studies of anticancer agents. Eur J Clin Pharmacol 57:211–219

    Article  CAS  PubMed  Google Scholar 

  67. Delacher S, Derendorf H, Hollenstein U, Brunner M, Joukhadar C, Hofmann S, Georgopoulos A, Eichler HG, Muller M (2000) A combined in vivo pharmacokinetic and in vitro pharmacodynamic approach to simulate target site pharmacodynamics of antibiotics in humans. J Antimicrob Chemother 46(5):733–739

    Article  CAS  PubMed  Google Scholar 

  68. Hickner RC (2000) Applications of microdialysis in studies of exercise. Exerc Sport Sci Rev 28(3):117–222

    CAS  PubMed  Google Scholar 

  69. Hickner RC, Racette SB, Binder EF, Fisher JS, Kohrt WM (1999) Suppression of whole body and regional lipolysis by insulin: effects of obesity and exercise. J Clin Endocrinol Metab 84:3886–3895

    CAS  PubMed  Google Scholar 

  70. Hickner RC, Racette SB, Binder EF, Fisher JS, Kohrt WM (2000) Effects of 10 days of endurance exercise training on the suppression of whole body and regional lipolysis by insulin. J Clin Endocrinol Metab 85:1498–1504

    CAS  PubMed  Google Scholar 

  71. Reinert M, Khaldi A, Zauner A, Doppenberg E, Choi S, Bullock R (2000) High level of extracellular potassium and its correlates after severe head injury: relationship to high intracranial pressure. J Neurosurg 93:800–807

    Article  CAS  PubMed  Google Scholar 

  72. Baunach S, Meixensberger J, Gerlach M, Lan J, Roosen K (1998) Intraoperative microdialysis and tissue-pO2 measurement in human glioma. Acta Neurochir Suppl (Wein) 71:241–243

    CAS  Google Scholar 

  73. Adamides AA, Rosenfeldt FL, Winter CD et al (2009) Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury. J Am Coll Surg 2009:531–539

    Article  Google Scholar 

  74. Waelgaard L, Thorgerson EB, Line PD et al (2008) Microdialysis monitoring of liver grafts by metabolic parameters, cytokine production, and complement activation. Transplantation 86:1096–1103

    Article  CAS  PubMed  Google Scholar 

  75. Keller AK, Jorgensen TM, Ravlo K et al (2009) Microdialysis for detection of renal ischemia after experimental renal transplantation. J Urol 182(4 Suppl):1854–1859

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Austin J. Combest Pharm.D., M.B.A.

  2. Pharmaceutical Product Development, Inc., Morrisville, NC, 27560, USA

    Austin J. Combest Pharm.D., M.B.A.

  3. Division of Pharmacotherapy and Experimental Therapeutics, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

    William C. Zamboni Pharm.D., Ph.D.

  4. Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA

    William C. Zamboni Pharm.D., Ph.D.

  5. GLP Analytical Facility, Center for Experimental Therapeutics, School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, 27599, USA

    William C. Zamboni Pharm.D., Ph.D.

  6. Translational Oncology and Nanoparticle Drug Development Initiative (TONDI) Lab, UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    William C. Zamboni Pharm.D., Ph.D.

  7. North Carolina Bioanalytical Innovation Network, Chapel Hill, NC, 27599, USA

    William C. Zamboni Pharm.D., Ph.D.

  8. Division of Pharmacotherapy and Experimental Therapeutics, University of North Carolina Eshelman School of Pharmacy, 1013 Genetic Medicine Building CB 7360, Chapel Hill, NC, 27599-7360, USA

    William C. Zamboni Pharm.D., Ph.D.

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  1. Austin J. Combest Pharm.D., M.B.A.
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Correspondence to William C. Zamboni Pharm.D., Ph.D. .

Editor information

Editors and Affiliations

  1. Sidney Kimmel Comprehensive Cancer Cente, Baltimore, Maryland, USA

    Michelle A. Rudek

  2. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    Cindy H. Chau

  3. Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA

    William D. Figg

  4. Moffitt Cancer Center, Tampa, Florida, USA

    Howard L. McLeod

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Combest, A.J., Zamboni, W.C. (2014). Microdialysis. In: Rudek, M., Chau, C., Figg, W., McLeod, H. (eds) Handbook of Anticancer Pharmacokinetics and Pharmacodynamics. Cancer Drug Discovery and Development. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9135-4_24

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