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DNA Repair: ERCC1, Nucleotide Excision Repair, and Platinum Resistance

  • Eddie Reed
  • Teri L. Larkins
  • Cindy H. Chau
  • William D. Figg
Chapter
Part of the Cancer Drug Discovery and Development book series (CDD&D)

Abstract

DNA excision repair plays a significant part in platinum-based chemotherapy by removing DNA lesions caused by platinum-containing drugs. The nucleotide excision repair (NER) pathway is the mammalian DNA repair mechanism that removes bulky DNA adducts induced by DNA damaging chemotherapeutic agents. Platinum compounds induce their cytotoxic effect by binding to a DNA molecule in the form of a platinum-DNA-adduct. The NER pathway is the main mechanism responsible for platinum resistance by increased platinum-DNA-adduct removal and the excision repair cross complementing-group 1 (ERCC1) gene plays a major role in the NER-pathway because of its damage recognition and excision ability. This chapter will review mechanisms of DNA repair and platinum resistance as it relates to the NER pathway and regulation of ERCC1. A brief discussion on the role of cancer stem cells in platinum resistance is also presented.

Keywords

ERCC1 Nucleotide excision repair Hedgehog 

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Eddie Reed
    • 1
  • Teri L. Larkins
    • 2
  • Cindy H. Chau
    • 3
  • William D. Figg
    • 3
  1. 1.National Institute on Minority Health and Health Disparities, National Institutes of HealthBethesdaUSA
  2. 2.Mitchell Cancer InstituteUniversity of South AlabamaMobileUSA
  3. 3.Center for Cancer ResearchNational Cancer InstituteBethesdaUSA

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