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Focal Ischemic White Matter Injury in Experimental Models

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White Matter Injury in Stroke and CNS Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 4))

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Abstract

The pathophysiology of central white matter is a timely subject for review. Early white matter changes are now recognized in neurological disorders ranging from Alzheimer’s and Parkinson’s diseases and vascular dementia to disorders such as diabetic cognitive dysfunction, mitochondrial syndromes, lysosomal disorders, and psychiatric illness. A plot of the use of the term “white matter” in the titles of research papers reveals an exponential growth since 2005, in large part due to this burst in interest in white matter as an early and possibly causal locus in disorders that until recently were thought to be exclusively gray matter in origin.

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Authors and Affiliations

  1. Cell Physiology and Pharmacology, University of Leicester, Leicester, LE1 9HN, UK

    Robert Fern Ph.D.

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  1. Robert Fern Ph.D.
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Correspondence to Robert Fern Ph.D. .

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Editors and Affiliations

  1. Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Selva Baltan

  2. Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA

    S. Thomas Carmichael

  3. Departamento de Neurociencias, Achucarro Basque Centger for Neuroscience, University del Pais Vasco (UPV/EHU), and Centro de, Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Leioa, Spain

    Carlos Matute

  4. University of Michigan Dept. Neurosurgery, Ann Arbor, Michigan, USA

    Guohua Xi

  5. Dept. Pharmacology Dept. Neurosurgery, Loma Linda University Dept. Physiology, Loma Linda, California, USA

    John H Zhang

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Fern, R. (2014). Focal Ischemic White Matter Injury in Experimental Models. In: Baltan, S., Carmichael, S., Matute, C., Xi, G., Zhang, J. (eds) White Matter Injury in Stroke and CNS Disease. Springer Series in Translational Stroke Research, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9123-1_8

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  • DOI: https://doi.org/10.1007/978-1-4614-9123-1_8

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