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Mechanisms Underlying the Selective Vulnerability of Developing Human White Matter

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White Matter Injury in Stroke and CNS Disease

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 4))

Abstract

This review focuses on what we have learned about why periventricular leukomalacia is a lesion characteristic of the developing human brain, the conspicuous gaps in this knowledge, and what this knowledge tells us about how to approach treating it. Here, the focus is on the acute lesion and what is hypothesized to be the initiating event in producing this lesion, which, as is made clear, is injury and death of developing oligodendrocytes.

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  1. Neurology, Children’s Hospital Boston, 300 Longwood Ave., Boston, MA, 02115, USA

    Paul A. Rosenberg M.D., Ph.D.

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Editors and Affiliations

  1. Cleveland Clinic Lerner Research Institute, Cleveland, Ohio, USA

    Selva Baltan

  2. Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA

    S. Thomas Carmichael

  3. Departamento de Neurociencias, Achucarro Basque Centger for Neuroscience, University del Pais Vasco (UPV/EHU), and Centro de, Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Leioa, Spain

    Carlos Matute

  4. University of Michigan Dept. Neurosurgery, Ann Arbor, Michigan, USA

    Guohua Xi

  5. Dept. Pharmacology Dept. Neurosurgery, Loma Linda University Dept. Physiology, Loma Linda, California, USA

    John H Zhang

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Rosenberg, P.A. (2014). Mechanisms Underlying the Selective Vulnerability of Developing Human White Matter. In: Baltan, S., Carmichael, S., Matute, C., Xi, G., Zhang, J. (eds) White Matter Injury in Stroke and CNS Disease. Springer Series in Translational Stroke Research, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-9123-1_6

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