White Matter Injury After Experimental Intracerebral Hemorrhage

  • Kenneth R. Wagner
Part of the Springer Series in Translational Stroke Research book series (SSTSR, volume 4)


Of the three stroke subtypes, spontaneous intracerebral hemorrhage (ICH) has the highest death rate and the poorest prognosis in survivors. Indeed, half of ICH patients die and only 10–20 % return to normal activities of daily living. Although the incidence of spontaneous ICH is estimated at ~10–15 % of all strokes, approximately 2 million patients are affected yearly worldwide. Besides spontaneous ICH, intracerebral bleeds also occur following treatment with thrombolytic agents for ischemic stroke and myocardial infarction. At present, there are no approved pharmacologic or generally accepted surgical treatments.


White Matter White Matter Injury White Matter Fiber Tract Perihematomal Edema Edema Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Amyloid precursor protein


Blood–brain barrier


Central nervous system


Glial fibrillary acidic protein


Hematoxylin and eosin


Heme oxygenase-1


Intracellular adhesion molecule-1




Intracerebral hemorrhage


Luxol fast blue


Mitogen-activated protein kinases


Monocyte chemoattractant protein


Magnetic resonance imaging


Matrix metalloproteinases


Nuclear factor-kappaB


Nitric oxide synthase


Nuclear factor (erythroid-derived 2)-like factor 2


Peroxisome proliferator-activated receptor-gamma


Reactive oxygen species


Proteinase-activated receptors


Surgical trial in intracerebral hemorrhage


Traumatic brain injury


Tumor necrosis factor-alpha


Terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine (dUTP)-biotin nick end labeling



The studies from the author’s laboratory that are described in this review were supported by National Institutes of Health grant R01NS30652 and funds from the Office of Research and Development, Medical Research Service, Department of Veterans Affairs.


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© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Research (151), Department of Veterans Affairs Medical CenterCincinnatiUSA
  2. 2.Department NeurologyUniversity of Cincinnati College of MedicineCincinnatiUSA

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