Metabolic Alkalosis

  • Alluru S. ReddiEmail author


Metabolic alkalosis is defined as a primary increase in serum [HCO3 ] > 32 mEq/L with pH > 7.45. Hypoventilation with an increase in arterial pCO2 is an appropriate respiratory response for an increase in serum [HCO3 ]. Thus, metabolic alkalosis is characterized by an elevated pH, an increase in serum [HCO3 ], and an elevated pCO2. The course of metabolic alkalosis is divided into three phases: generation phase, maintenance phase, and recovery phase.


Metabolic alkalosis Metabolic alkalosis causes Metabolic alkalosis manifestations Course of metabolic alkalosis Electrolytes and pH in metabolic alkalosis 

Suggested Reading

  1. 1.
    Gennari FJ. Metabolic alkalosis. In: Mount DB, Sayegh MH, Singh AJ, editors. Core concepts in the disorders of fluid, electrolytes and acid-base balance. New York: Springer; 2013. pp. 275–96.CrossRefGoogle Scholar
  2. 2.
    Gennari FJ. Pathophysiology of metabolic alkalosis: a new classification based on the centrality of stimulated collecting duct ion transport. Am J Kidney Dis. 2011;58:626–36.PubMedCrossRefGoogle Scholar
  3. 4.
    Galla JH. Metabolic alkalosis. J Am Soc Nephrol. 2000;11:369–75.PubMedGoogle Scholar
  4. 3.
    Kandasamy N, Fugazola L, Evans M, et al. Life-threatening metabolic alkalosis in pendred syndrome. Eur J Endocrinol. 2011;165:167–70.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Reimann D, Gross P. Chronic, diagnosis-resistant hypokalaemia. Nephrol Dial Transplant. 1999;14:2957–61.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Medicine Division of Nephrology and HypertensionRutgers New Jersey Medical SchoolNewarkUSA

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