Mechanisms of Liver Injury



A diverse range of pathophysiologic processes lead to liver injury in the pediatric population. This chapter discusses mechanisms of hepatocyte or other liver cellular injury, beginning with a brief discussion of liver functions and general mechanisms of cell death. Particular attention is paid to the role of apoptotic pathways and mitochondrial damage in liver diseases, including metabolic disorders, infections, toxin ingestions, and diseases that primarily affect the biliary tree.


Bile Acid Primary Biliary Cirrhosis Primary Sclerosing Cholangitis Biliary Atresia Gauche Disease 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Pediatric Surgery, Department of SurgeryUniversity of Washington School of Medicine, Seattle Children’s HospitalSeattleUSA
  2. 2.Department of PathologyUniversity of WashingtonSeattleUSA

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