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Carbon Nanotubes: From Synthesis to Genotoxicity

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Nanotoxicology

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

Massive industrial production of carbon nanotubes (CNTs) is increasing year after year, and it is urgent to address their safety-related issues. Due to their morphological similarities with asbestos fibers, which are classical carcinogenic materials, these CNTs have been considered as hazardous manufactured products by regulatory agencies. In this context, genotoxic effects of CNTs and the mechanisms proposed in current literature are reviewed and discussed in this chapter. Relevant aspects of preparation and physicochemical characterization of CNTs in toxicological context as well as the recent perspectives involving cytotoxicity assessment are also highlighted. Finally, this chapter aims to contribute to point out to a proactive discussion towards a responsible and sustainable development of nanotechnology lined up with environmental, health, and safety (EH&S) requirements.

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Acknowledgments

D.S.T.M. and O.L.A. thank INCT-Inomat and Brazilian Nanotoxicology Network—CIGENANOTOX; L.P.F. and C.M.F. acknowledge the FAPESP for doctorate fellowships; O.P.F. and A.G.S.F. acknowledge CNPq, FUNCAP, PRONEX, INCT-NanoBioSimes, and Núcleo de Estudos em Nanoestruturas de Carbono; D.S.T.M. and A.G.S.F. thank the European Union Seventh Framework Programme (FP7) Small Collaborative project, Neuronano (NMP4-SL-2008-214547); A.G.S.F. and O.L.A. thank PROCAD-CAPES program. The authors thank Prof Dr Gisela A. Umbuzeiro for discussions and valuable suggestions.

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  1. Solid State Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Cidade Universitária “Zeferino Vaz”-Barão Geraldo, Campinas, São Paulo, 13083-970, Brazil

    Diego Stéfani T. Martinez & Oswaldo L. Alves

  2. Department of Genetics, Faculty of Medicine of Ribeirão Preto, Universidade de São Paulo–USP, Ribeirão Preto, São Paulo, 14049-900, Brazil

    Leonardo P. Franchi & Catarina S. Takahashi

  3. Department of Structural and Functional Biology, Institute of Biology, Universidade Estadual de Campinas—UNICAMP, Cidade Universitária “Zeferino Vaz”- Barão Geraldo, Campinas, São Paulo, 13083-862, Brazil

    Camila M. Freria

  4. Advanced Functional Materials Laboratory, Department of Physics, Universidade Federal do Ceará–UFC, Fortaleza, Ceará, 60440-554, Brazil

    Odair P. Ferreira

  5. Departamento de Física, Universidade Federal do Ceará–UFC, Fortaleza, Ceara, 60440-554, Brazil

    Antonio G. Souza Filho

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  1. Diego Stéfani T. Martinez
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Correspondence to Diego Stéfani T. Martinez .

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  1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Nelson Durán

  2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Silvia S. Guterres

  3. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Oswaldo L. Alves

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Martinez, D.S.T. et al. (2014). Carbon Nanotubes: From Synthesis to Genotoxicity. In: Durán, N., Guterres, S., Alves, O. (eds) Nanotoxicology. Nanomedicine and Nanotoxicology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8993-1_6

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