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Assessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions

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Nanotoxicology

Part of the book series: Nanomedicine and Nanotoxicology ((NANOMED))

Abstract

The challenge of nanotoxicology implies development of new methods and improvements of current ones to study the interface of nanomaterials and toxicological science. The nanoscale of materials provides new insights regarding their effects to cells, tissues, and organisms. The blood biocompatibility of nanomaterials is in the light of medical applications and hemolysis assay is pointed out as an important tool to bring toxicological information. Cell membrane disruption by nanomaterials is easily detected by free hemoglobin from red blood cells (RBCs), called erythrocytes. Moreover, nanomaterials’ physicochemical properties play a key role for understanding erythrocyte toxicity as well as their biomolecular surface chemistry interactions in biological fluids. In this way, this chapter aims to give an overview of nanomaterials toxicity to RBCs, focusing the current methods in nanotoxicology and exploring the advances in bionanointerface.

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Acknowledgments

The authors thank CNPq, FAPESP, INCT-Imonat, and the Brazilian Nanotoxicology Network—CIGENANOTOX.

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Authors and Affiliations

  1. Solid State Chemistry Laboratory, Institute of Chemistry, University of Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Luis A. Visani de Luna

  2. Solid State Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Cidade Universitária “Zeferino Vaz”—Barão Geraldo, Campinas, Sao Paulo, 13083-970, Brazil

    Diego Stéfani T. Martinez

  3. Solid State Chemistry Laboratory, Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Oswaldo L. Alves

Authors
  1. Luis A. Visani de Luna
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  2. Diego Stéfani T. Martinez
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  3. Oswaldo L. Alves
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Corresponding author

Correspondence to Diego Stéfani T. Martinez .

Editor information

Editors and Affiliations

  1. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Nelson Durán

  2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil

    Silvia S. Guterres

  3. Institute of Chemistry, Universidade Estadual de Campinas—UNICAMP, Campinas, São Paulo, Brazil

    Oswaldo L. Alves

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de Luna, L.A.V., Martinez, D.S.T., Alves, O.L. (2014). Assessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions. In: Durán, N., Guterres, S., Alves, O. (eds) Nanotoxicology. Nanomedicine and Nanotoxicology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8993-1_16

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