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Pharmacology of Local Anesthetics

Chapter

Abstract

The development of local anesthetics dates to the first use by the Incas of Peru, using cocaine for its medicinal properties. They treated headaches with trepanation or by burrowing holes in the skull with chewed cocaine as the local anesthetic. Today, the use of local anesthetics by anesthesia providers has gained increasing popularity, traditionally in both obstetric and regional anesthesia. This chapter will focus on the types of local anesthetics, dosing and mechanism of action, indications with clinical pearls, and drug interactions/toxicity profile.

Keywords

Local Anesthetic Peripheral Nerve Block Local Anesthetic Toxicity Central Nervous System Toxicity Amino Amide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyUCLA- Santa Monica Medical Center and Orthopedic HospitalSanta MonicaUSA
  2. 2.Department of AnesthesiologyRonald Reagan UCLA Medical CenterLos AngelesUSA
  3. 3.Department of Anesthesiology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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