Pharmacology of Local Anesthetics



The development of local anesthetics dates to the first use by the Incas of Peru, using cocaine for its medicinal properties. They treated headaches with trepanation or by burrowing holes in the skull with chewed cocaine as the local anesthetic. Today, the use of local anesthetics by anesthesia providers has gained increasing popularity, traditionally in both obstetric and regional anesthesia. This chapter will focus on the types of local anesthetics, dosing and mechanism of action, indications with clinical pearls, and drug interactions/toxicity profile.


Local Anesthetic Peripheral Nerve Block Local Anesthetic Toxicity Central Nervous System Toxicity Amino Amide 
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Supplementary material


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© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Department of AnesthesiologyUCLA- Santa Monica Medical Center and Orthopedic HospitalSanta MonicaUSA
  2. 2.Department of AnesthesiologyRonald Reagan UCLA Medical CenterLos AngelesUSA
  3. 3.Department of Anesthesiology, David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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