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Pharmacokinetics and Pharmacodynamics of Anesthetics

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Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care

Abstract

Pharmacokinetics (PK) is the study of drug concentration in the body with respect to time. The four major processes affecting drug concentration are drug absorption, distribution, metabolism, and excretion. In examining the PK processes, this chapter aims to provide considerations in drug absorption, the concept of drug distribution, metabolism and drug interactions, and renal excretion. PK parameters area under the curve (AUC), elimination rate constant (k), half-life (t1/2), clearance (Cl), and volume of distribution (Vd) are introduced to provide clinicians an understanding of the PK of anesthetic agents. Pharmacodynamics (PD) is the study of drug action in the body with respect to time. Taken together, the understanding of PK and PD will aid a clinician in the design of anesthetic doses and dosing frequencies to achieve desired therapeutic effects while minimizing adverse reactions.

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Authors and Affiliations

  1. Department of Pharmacy Practice and Administration, Western University of Health Sciences, Pomona, CA, USA

    Patrick Chan PharmD, PhD

  2. Department of Pharmaceutics and Medicinal Chemistry, University of the Pacific, Stockton, CA, USA

    James A. Uchizono PharmD, PhD

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  1. Patrick Chan PharmD, PhD
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  2. James A. Uchizono PharmD, PhD
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Correspondence to Patrick Chan PharmD, PhD .

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Editors and Affiliations

  1. Departments of Anesthesiology and Pharmacology, LSU Health Sciences Center, New Orleans, Louisiana, USA

    Alan David Kaye

  2. Department of Pharmacy Practice, Thomas J. Long School of Pharmacy and Health Sciences, Stockton, California, USA

    Adam M. Kaye

  3. Center for Perioperative Management and Medical Informatics, Brigham and Women’s Hospital, Boston, Massachusetts, USA

    Richard D. Urman

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Chan, P., Uchizono, J.A. (2015). Pharmacokinetics and Pharmacodynamics of Anesthetics. In: Kaye, A., Kaye, A., Urman, R. (eds) Essentials of Pharmacology for Anesthesia, Pain Medicine, and Critical Care. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8948-1_1

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