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Vascular Inflammation in Ischemic Stroke: Adhesion Receptors Controlling Leukocyte–Endothelial Interactions

  • Stephen F. Rodrigues
  • D. Neil Granger
Chapter
Part of the Springer Series in Translational Stroke Research book series (SSTSR, volume 6)

Abstract

The contribution of leukocytes to the pathogenesis of ischemic stroke has been extensively studied and thoroughly documented. In this chapter, different aspects of leukocyte involvement in the lesion formation caused by ischemic stroke are highlighted, including the inflammatory agents that mediate leukocyte recruitment to the site of injury, the primary leukocyte populations that contribute to tissue damage, and the adhesion receptors that control leukocyte–endothelial cell interactions in post-ischemic brain. Agents that interfere with leukocyte recruitment in the brain are also addressed as potential therapeutic interventions for ischemic stroke.

Keywords

Ischemic Stroke Middle Cerebral Artery Occlusion Infarct Volume Neutrophil Elastase Leukocyte Recruitment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Clinical and Toxicological AnalysesUniversity of Sao PauloSao PauloBrazil
  2. 2.Molecular and Cellular PhysiologyLouisiana State University Health Sciences CenterBaton RougeUSA

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