In Vivo Imaging of Neuroinflammation in Acute Brain Injury

Part of the Springer Series in Translational Stroke Research book series (SSTSR, volume 6)


Neuroinflammation is a dynamic process which undergoes significant changes in spatial distribution and intensity within hours and days after an acute brain injury. At present non-invasive in vivo imaging methods like positron emission tomography (PET) offer the only possibility to capture this dynamics longitudinally in the same subject and the entire brain. Amongst the multitude of cellular and non-cellular mechanisms which constitute the complex neuroinflammatory reaction, microglia and macrophages have been the primary targets for developing non-invasive imaging methods. This chapter is an introduction into the basic principles of microglia imaging with PET, its application to ischaemic stroke and traumatic brain injury in both animal models and clinical imaging in patients. Future developments towards magnetic resonance imaging (MRI) of neuroinflammation and imaging of specific enzyme activity in the neuroinflammatory cascade are discussed.


Positron Emission Tomography Microglia Activity Acute Brain Injury Transient Middle Cerebral Artery Occlusion TSPO Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Neurology and NeurosurgeryMcGill UniversityMontrealCanada

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