Abstract
In this chapter, we will briefly describe a hypothesis of virus-driven atherosclerosis. First, we will write about the pathogenetic basis of atherosclerosis, then we will note the possible place of infectious agents in this pathological process, and, finally, we will consider a number of mechanisms which underlie the hypothesis of virus-driven atherosclerosis.
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References
Hansson GK. Mechanisms of disease: inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352(16):1685–95.
Hansson GK, Robertson AK, Soderberg-Naucler C. Inflammation and atherosclerosis. Annu Rev Pathol. 2006;1:297–329.
Galkina E, Ley K. Immune and inflammatory mechanisms of atherosclerosis. Annu Rev Immunol. 2009;27:165–97.
Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med. 2011;17(11):1410–22.
Steinberg D. Atherogenesis in perspective: hypercholesterolemia and inflammation as partners in crime. Nat Med. 2002;8(11):1211–7.
Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S, et al. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils inatherosclerosis. Circ Res. 2008;102(2):209–17.
Drechsler M, Megens RT, van Zandvoort M, Weber C, Soehnlein O. Hyperlipidemia-triggered neutrophilia promotes early atherosclerosis. Circulation. 2010;122(18):1837–45.
Manthey HD, Zernecke A. Dendritic cells in atherosclerosis: functions in immune regulation and beyond. Thromb Haemost. 2011;106(5):772–8.
Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens RT, et al. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011;121(7):2898–910.
Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993;362(6423):801–9.
Libby P. Inflammation in atherosclerosis. Nature. 2002;420(6917):868–74.
Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol. 2008;8(10):802–15.
Benditt EP, Barrett T, McDougall JK. Viruses in the etiology of atherosclerosis. Proc Natl Acad Sci U S A. 1983;80:6386–9.
Valtonen VV. Infection as a risk factor for infarction and atherosclerosis. Ann Med. 1991;23(5):539–43.
Xu Q, Willeit J, Marosi M, Kleindienst R, Oberhollenzer F, Kiechl S, Stulnig T, Luef G, Wick G. Association of serum antibodies to heat-shock protein 65 with carotid atherosclerosis. Lancet. 1993;341(8840):255–9.
Rosenfeld ME, Campbell LA. Pathogens and atherosclerosis: update on the potential contribution of multiple infectious organisms to thepathogenesis of atherosclerosis. Thromb Haemost. 2011;106(5):858–67.
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Kutikhin, A., Brusina, E., Yuzhalin, A.E. (2013). A Hypothesis of Virus-Driven Atherosclerosis. In: Viruses and Atherosclerosis. SpringerBriefs in Immunology, vol 4. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8863-7_1
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DOI: https://doi.org/10.1007/978-1-4614-8863-7_1
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