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Molecular Determinants of Head and Neck Cancer pp 325–341Cite as

Gene Expression in HNC

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Part of the book series: Current Cancer Research ((CUCR))

Abstract

Head and Neck Cancer (HNC), which is most commonly Head and Neck Squamous Cell Carcinoma (HNSCC), shows substantial changes in gene transcription, as typical for other cancers. In contrast to many cancers, methylation, especially global hypomethylation and variable promoter methylation, plays a major role in control of expression in HNC. This methylation drives not only changes in expression levels but also changes in splicing. Here we discuss the present state of research in gene expression signatures, epigenetic regulation, microRNA expression, and alternative splicing in HNC.

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Authors and Affiliations

  1. Department of Oncology, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Michael F. Ochs & Joseph A. Califano

  2. Department of Mathematics and Statistics, The College of New Jersey, Ewing, NJ, USA

    Michael F. Ochs

  3. Department of Otolaryngology—Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, MD, USA

    Joseph A. Califano

  4. Milton J. Dance Head and Neck Center, Greater Baltimore Medical Center, Baltimore, MD, USA

    Joseph A. Califano

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  1. Michael F. Ochs
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  2. Joseph A. Califano
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Correspondence to Joseph A. Califano .

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Editors and Affiliations

  1. Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Barbara Burtness

  2. Developmental Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA

    Erica A. Golemis

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Ochs, M., Califano, J. (2014). Gene Expression in HNC. In: Burtness, B., Golemis, E. (eds) Molecular Determinants of Head and Neck Cancer. Current Cancer Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8815-6_16

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  • DOI: https://doi.org/10.1007/978-1-4614-8815-6_16

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