Particle Dynamics and Design of Nano-drug Delivery Systems

Chapter

Abstract

Drug delivery systems are a very valuable instrument for cardiovascular and oncological applications, as well as for biomedical imaging. In this type of systems, it is very significant to achieve particle margination, i.e., the capability of particles to move through blood vessels towards the endothelium and sense biological and biophysical varieties. Numerical modeling of particle motion is important since it can simplify the analysis of influence of various parameters relevant in design of nanoparticles, such as size, shape, and surface characteristics. In this chapter lattice Boltzmann method was used to simulate motion of particles through fluid domain, and a specific type of particle-fluid interaction was modeled. Movement of both spherical and nonspherical particles was analyzed in classical test cases and diverse complex geometrical fluid domains. Agreement between lattice Boltzmann method and analytical solutions obtained with other methods indicates that this method and the developed software can be used to accurately model fluid flow in complex geometries and fluid-particle interaction in microcirculation, which is especially useful for simulations of particle transport and margination to the vessel walls, bio-imaging, and drug delivery.

Keywords

Permeability Torque Sedimentation 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Faculty of Engineering, R&D Center for BioengineeringKragujevacSerbia

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