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Langerhans Cell Histiocytosis

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Pediatric Head and Neck Tumors

Abstract

Langerhans cell histiocytosis is characterized by the clonal proliferation of histiocytes, a type of white blood cell, in various organs of the body. There is a large range of presentations, from isolated lesions, most often of bone, to widespread, multisystem disease. Disease that appears to be isolated may be more widespread either at diagnosis or in the future, so broad workup and vigilant surveillance is required. Patients with involvement of only one organ system can often be cured with surgical resection or curettage alone, whereas patients with involvement of high-risk bony sites, risk organs, or widespread disease require chemotherapy and have variable outcomes.

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Author information

Authors and Affiliations

  1. Pediatric Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Dana 3, 02458, Boston, MA, USA

    Adam L. Green MD

  2. Department of Pediatric Oncology, Dana-Farber/Boston Children’s Hospital Cancer and Blood Disorders Center, Harvard Medical School, 450 Brookline Avenue D3-133, 02215, Boston, MA, USA

    Assoc. Prof. Carlos Rodriguez-Galindo MD

Authors
  1. Adam L. Green MD
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  2. Assoc. Prof. Carlos Rodriguez-Galindo MD
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Corresponding author

Correspondence to Carlos Rodriguez-Galindo MD .

Editor information

Editors and Affiliations

  1. Department of Otolaryngology, Harvard Medical School Boston Children's Hospital, Boston, Massachusetts, USA

    Reza Rahbar

  2. Harvard Medica School, Dana-Farber/Boston Childrens Cancer and Blood Disorders Center, Boston, Massachusetts, USA

    Carlos Rodriguez-Galindo

  3. Department of Plastic Surgery, Harvard Medical School Boston Children's Hospital, Boston, Massachusetts, USA

    John G. Meara

  4. Department of Neurosurgery, Harvard Medical School Boston Children's Hospital, Boston, Massachusetts, USA

    Edward R. Smith

  5. Department of Pathology, Harvard Medical School Boston Children's Hospital, Boston, Massachusetts, USA

    Antonio R. Perez-Atayde

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Green, A., Rodriguez-Galindo, C. (2014). Langerhans Cell Histiocytosis. In: Rahbar, R., Rodriguez-Galindo, C., Meara, J., Smith, E., Perez-Atayde, A. (eds) Pediatric Head and Neck Tumors. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8755-5_26

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  • DOI: https://doi.org/10.1007/978-1-4614-8755-5_26

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