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Vascular Mechanisms in CNS Trauma pp 239–253Cite as

Vascular Responses in Rodent Models of Traumatic Brain Injury

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Part of the book series: Springer Series in Translational Stroke Research ((SSTSR,volume 5))

Abstract

The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant barriers to finding effective therapeutic interventions. Among multiple confirmed pathological events after TBI, vascular response or cerebrovascular pathophysiology is one of the most important pathophysiological components of TBI, but its role and molecular mechanisms remain largely unknown. This chapter reviews experimental studies of cerebrovascular pathophysiology, especially in rodent TBI models. Clinically translational advantages and limitations of each commonly used rodent TBI models in the study of vascular responses are also discussed.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

    Xiaoshu Wang

  2. Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Xiaoshu Wang

  3. Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA

    Zhanyang Yu, Zhengbu Liao & Xiaoying Wang

  4. Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chonqing, China

    Zhengbu Liao & Xiaochuan Sun

  5. Neuroprotection Research Laboratory, Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Qi Liu & MingMing Ning

  6. Neuroprotection Research Laboratory and Department of Pediatrics, Division of Pediatric Critical Care Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Josephine Lok

  7. Departments of Neurology and Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Eng H. Lo

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  1. Xiaoshu Wang
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  2. Zhanyang Yu
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  4. Qi Liu
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  6. Xiaochuan Sun
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  7. Josephine Lok
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  8. Eng H. Lo
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  9. Xiaoying Wang
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Correspondence to Xiaoshu Wang .

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Editors and Affiliations

  1. Departments of Neurology and Radiology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Eng H. Lo

  2. Department of Pediatrics, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    Josephine Lok

  3. Department of Neurology, Massachusetts General Hospital Harvard Medical School, Boston, Massachusetts, USA

    MingMing Ning

  4. Department of Pediatrics, Massachusetts General Hospital Harbard Medical School, Boston, Massachusetts, USA

    Michael J. Whalen

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Wang, X. et al. (2014). Vascular Responses in Rodent Models of Traumatic Brain Injury. In: Lo, E., Lok, J., Ning, M., Whalen, M. (eds) Vascular Mechanisms in CNS Trauma. Springer Series in Translational Stroke Research, vol 5. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8690-9_13

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