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Malignant Ovarian Tumors (Serous/Mucinous/Endometrioid/Clear Cell Carcinoma): Clinical Setting and Ultrasound Appearance

  • Juan Luis AlcázarEmail author
  • Jesús Utrilla-Layna
Chapter

Abstract

Epithelial ovarian cancer remains as the most deadly gynecological malignancy and it is the seventh leading cause of cancer in women in developed countries. Worldwide more than 200,000 new cases are diagnosed annually, resulting in more than 140,000 deaths. Histologically, ovarian malignancies are classified in two broad groups: epithelial and non-epithelial ovarian cancer. Epithelial ovarian cancers are subclassified based on hystotype, with serous, endometrioid, clear cell, and mucinous carcinomas accounting for 96 % of all cases. In this chapter we shall review the origin, clinical setting, and ultrasound appearance of serous, endometrioid, and mucinous carcinomas.

Keywords

Serous carcinoma Mucinous carcinoma Endometrioid carcinoma Clear cell Imaging Ultrasound 

References

  1. 1.
    Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin. 2011;61:69–90.PubMedCrossRefGoogle Scholar
  2. 2.
    Chen VW, Ruiz B, Killeen JL, Coté TR, Wu XC, Correa CN. Pathology and classification of ovarian tumors. Cancer. 2003;97:2631–42.PubMedCrossRefGoogle Scholar
  3. 3.
    Chan A, Gilks B, Kwon J, Tinker AV. New insights into the pathogenesis of ovarian carcinoma: time to rethink ovarian cancer screening. Obstet Gynecol. 2012;120:935–40.PubMedCrossRefGoogle Scholar
  4. 4.
    Kurman RJ. Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer – shifting the paradigm. Human Pathol. 2011;42:918–31.CrossRefGoogle Scholar
  5. 5.
    Plaxe SC. Epidemiology of low-grade serous ovarian cancer. Am J Obstet Gynecol. 2008;198:459.e1–8.CrossRefGoogle Scholar
  6. 6.
    Lalwani N, Prasad SR, Vikram R, Shanbhogue AK, Huettner PC, Fasih N. Histologic, molecular, and cytogenetic features of ovarian cancers: implications for diagnosis and treatment. Radiographics. 2011;31:625–46.PubMedCrossRefGoogle Scholar
  7. 7.
    Golf B. Symptoms associated with ovarian cancer. Clin Obstet Gynecol. 2012;55:36–42.CrossRefGoogle Scholar
  8. 8.
    Kurman RJ, Visvanathan K, Roden R, Wu TC, Shih IM. Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis. Am J Obstet Gynecol. 2008;198:351–6.PubMedCentralPubMedCrossRefGoogle Scholar
  9. 9.
    Brown DL, Zou KH, Tempany CM, Frates MC, Silverman SG, McNeil BJ, Kurtz AB. Primary versus secondary ovarian malignancy: imaging findings of adnexal masses in the Radiology Diagnostic Oncology Group Study. Radiology. 2001;219:213–8.PubMedCrossRefGoogle Scholar
  10. 10.
    Alcázar JL, Galán MJ, Ceamanos C, García-Manero M. Transvaginal gray scale and color Doppler sonography in primary ovarian cancer and metastatic tumors to the ovary. J Ultrasound Med. 2003;22:243–7.PubMedGoogle Scholar
  11. 11.
    Valentin L, Ameye L, Testa A, Lécuru F, Bernard JP, Paladini D, Van Huffel S, Timmerman D. Ultrasound characteristics of different types of adnexal malignancies. Gynecol Oncol. 2006;102:41–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Antila R, Jalkanen J, Heikinheimo O. Comparison of secondary and primary ovarian malignancies reveals differences in their pre- and perioperative characteristics. Gynecol Oncol. 2006;101:97–101.PubMedCrossRefGoogle Scholar
  13. 13.
    Van Calster B, Valentin L, Van Holsbeke C, Testa AC, Bourne T, Van Huffel S, Timmerman D. Polytomous diagnosis of ovarian tumors as benign, borderline, primary invasive or metastatic: development and validation of standard and kernel-based risk prediction models. BMC Med Res Methodol. 2010;10:96.PubMedCentralPubMedCrossRefGoogle Scholar
  14. 14.
    Alcázar JL, Guerriero S, Pascual MÁ, Ajossa S, Olartecoechea B, Hereter L. Clinical and sonographic features of uncommon primary ovarian malignancies. J Clin Ultrasound. 2012;40:323–9.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyClínica Universidad de Navarra, University of NavarraPamplonaSpain
  2. 2.Department of Obstetrics and GynecologyClínica Universidad de NavarraPamplonaSpain

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