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Dysregulation of Long Non-coding RNAs in Human Disease

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Molecular Biology of Long Non-coding RNAs

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Abstract

The mammalian genome is composed of thousands of long non-coding RNAs (lncRNAs). Accumulating evidence suggests that lncRNAs play diverse biological roles through a variety of molecular mechanisms including epigenetic, transcriptional, and post-transcriptional regulation. This chapter reviews the molecular mechanisms of lncRNAs in gene regulation and the context of various human diseases associated with dysregulation of lncRNAs.

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  1. Program for RNA Biology, Sanford-Burnham Medical Research Institute, 10901 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Nianwei Lin & Tariq M. Rana

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Correspondence to Tariq M. Rana .

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  1. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Ahmad M. Khalil

  2. Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Jeff Coller

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Lin, N., Rana, T.M. (2013). Dysregulation of Long Non-coding RNAs in Human Disease. In: Khalil, A., Coller, J. (eds) Molecular Biology of Long Non-coding RNAs. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8621-3_5

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