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Inhaled Environmental Allergens and Toxicants as Determinants of the Asthma Phenotype

  • Kristin Sokol
  • Sanjiv Sur
  • Bill T. AmeredesEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 795)

Abstract

The driving environmental factors behind the development of the asthma phenotype remain incompletely studied and understood. Here, we present an overview of inhaled allergic/atopic and mainly nonallergic/nonatopic or toxicant shapers of the asthma phenotype, which are present in both the indoor and outdoor environment around us. The inhaled allergic/atopic factors include fungus, mold, animal dander, cockroach, dust mites, and pollen; these allergic triggers and shapers of the asthma phenotype are considered in the context of their ability to drive the immunologic IgE response and potentially induce interactions between the innate and adaptive immune responses, with special emphasis on the NADPH-dependent reactive oxygen-species-associated mechanism of pollen-associated allergy induction. The inhaled nonallergic/nonatopic, toxicant factors include gaseous and volatile agents, such as sulfur dioxide, ozone, acrolein, and butadiene, as well as particulate agents, such as rubber tire breakdown particles, and diesel exhaust particles. These toxicants are reviewed in terms of their relevant chemical characteristics and hazard potential, ability to induce airway dysfunction, and potential for driving the asthma phenotype. Special emphasis is placed on their interactive nature with other triggers and drivers, with regard to driving the asthma phenotype. Overall, both allergic and nonallergic environmental factors can interact to acutely exacerbate the asthma phenotype; some may also promote its development over prolonged periods of untreated exposure, or possibly indirectly through effects on the genome. Further therapeutic considerations should be given to these environmental factors when determining the best course of personalized medicine for individuals with asthma.

Keywords

Acrolein Adaptive immunity Butadiene Dust mites Tire breakdown particles Diesel exhaust particles Innate immunity NADPH oxidase Ozone Ragweed pollen Reactive oxygen species Sulfur dioxide 

References

  1. Abraham K, Andres S, Palavinskas R, Berg K, Appel KE, Lampen A (2011) Toxicology and risk assessment of acrolein in food. Mol Nutr Food Res 55(9):1277–1290. doi: 10.1002/mnfr.201100481 PubMedGoogle Scholar
  2. ACC (1992) Butadiene product summary. Products and technology. http://www.americanchemistry.com/butadiene
  3. Adachi K, Tainosho Y (2004) Characterization of heavy metal particles embedded in tire dust. Environ Int 30(8):1009–1017. doi: 10.1016/j.envint.2004.04.004 PubMedGoogle Scholar
  4. Amoore JE, Hautala E (1983) Odor as an aid to chemical safety: odor thresholds compared with threshold limit values and volatilities for 214 industrial chemicals in air and water dilution. J Appl Toxicol 3(6):272–290PubMedGoogle Scholar
  5. AQMD (2013) Ozone, 1976–2012. Historic air quality trends. http://www.aqmd.gov/smog/o3trend.html
  6. Arbes SJ Jr, Gergen PJ, Elliott L, Zeldin DC (2005) Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 116(2):377–383. doi: 10.1016/j.jaci.2005.05.017 PubMedGoogle Scholar
  7. Arntz D, Fischer A, Höpp M, Jacobi S, Sauer J, Ohara T, Sato T, Shimizu N, Schwind H (2007) Acrolein and methacrolein Ullmann’s encyclopedia of industrial chemistry. Wiley-VCH Verlag GmbH, WeinheimGoogle Scholar
  8. ATSDR (1992) Toxicological profile for 1,3-butadiene. Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services, Atlanta, GAGoogle Scholar
  9. Aubier M, Neukirch C, Peiffer C, Melac M (2001) Effect of cetirizine on bronchial hyperresponsiveness in patients with seasonal allergic rhinitis and asthma. Allergy 56(1):35–42PubMedGoogle Scholar
  10. Bacsi A, Dharajiya N, Choudhury BK, Sur S, Boldogh I (2005) Effect of pollen-mediated oxidative stress on immediate hypersensitivity reactions and late-phase inflammation in allergic conjunctivitis. J Allergy Clin Immunol 116(4):836–843. doi: 10.1016/j.jaci.2005.06.002 PubMedGoogle Scholar
  11. Bein K, Leikauf GD (2011) Acrolein—a pulmonary hazard. Mol Nutr Food Res 55(9):1342–1360. doi: 10.1002/mnfr.201100279 PubMedGoogle Scholar
  12. Blaisdell CJ, Weiss SR, Kimes DS, Levine ER, Myers M, Timmins S, Bollinger ME (2002) Using seasonal variations in asthma hospitalizations in children to predict hospitalization frequency. J Asthma 39(7):567–575PubMedGoogle Scholar
  13. Blanchard CL, Hidy GM, Tanenbaum S, Edgerton ES, Hartsell BE (2013) The Southeastern Aerosol Research and Characterization (SEARCH) study: temporal trends in gas and PM concentrations and composition, 1999–2010. J Air Waste Manag Assoc 63(3):247–259PubMedGoogle Scholar
  14. Borish L, Aarons A, Rumbyrt J, Cvietusa P, Negri J, Wenzel S (1996) Interleukin-10 regulation in normal subjects and patients with asthma. J Allergy Clin Immunol 97:1288–1296PubMedGoogle Scholar
  15. Brown DR (2007) Artificial turf: exposures to ground up rubber tires-athletic fields, playgrounds, garden mulch. In: Alderman N, Addiss S, Bradley J (ed) Environment and Public Health, North Haven, CT, pp. 36. http://www.ehhi.org/reports/turf/turf_report07.pdf
  16. Bryant DH, Burns MW, Lazarus L (1975) The correlation between skin tests, bronchial provocation tests and the serum level of IgE specific for common allergens in patients with asthma. Clin Allergy 5(2):145–157PubMedGoogle Scholar
  17. Buckley JP, Richardson DB (2012) Seasonal modification of the association between temperature and adult emergency department visits for asthma: a case-crossover study. Environ Health 11:55. doi: 10.1186/1476-069x-11-55 PubMedGoogle Scholar
  18. Burnett RT, Dales RE, Raizenne ME, Krewski D, Summers PW, Roberts GR, Brook J (1994) Effects of low ambient levels of ozone and sulfates on the frequency of respiratory admissions to Ontario hospitals. Environ Res 65(2):172–194PubMedGoogle Scholar
  19. Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 320(5):271–277. doi: 10.1056/nejm198902023200502 PubMedGoogle Scholar
  20. Cai C, Xu J, Zhang M, Chen XD, Li L, Wu J, Zhong NS (2008) Prior SO2 exposure promotes airway inflammation and subepithelial fibrosis following repeated ovalbumin challenge. Clin Exp Allergy 38(10):1680–1687. doi: 10.1111/j.1365-2222.2008.03053.x PubMedGoogle Scholar
  21. Caimmi D, Raschetti R, Pons P, Dhivert-Donnadieu H, Bousquet J, Demoly P (2012) Cross-reactivity between cypress pollen and latex assessed using skin tests. J Investig Allergol Clin Immunol 22(7):525–526PubMedGoogle Scholar
  22. Canova C, Dunster C, Kelly FJ, Minelli C, Shah PL, Caneja C, Burney P (2012) PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics. Epidemiology 23(4):607–615. doi: 10.1097/EDE.0b013e3182572563 PubMedGoogle Scholar
  23. Cass GR, Boone PM, Macias ES (1982) Emissions and air quality relationships for atmospheric carbon particles in Los Angeles. In: Wolff T, Klimisch RL (eds) Particulate carbon-atmospheric life cycle. Plenum, New York, NY, pp 207–240Google Scholar
  24. CDC (1992) Occupational safety and health guideline for butadiene (1,3-butadiene). http://www.cdc.gov/niosh/docs/81-123/pdfs/0067-rev.pdf
  25. CDC (1994a) Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs): acrolein. NIOSH Publications and Products. http://www.cdc.gov/niosh/docs/2005-149/pdfs/2005-149.pdf
  26. CDC (1994b) Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs): ozone. NIOSH Publications and Products. http://www.cdc.gov/niosh/idlh/10028156.html
  27. CDC (1995) Documentation for Immediately Dangerous to Life or Health Concentrations (IDLHs): Chemical listing and documentation of revised IDLH values. NIOSH Publications and Products. http://www.cdc.gov/niosh/idlh/intridl4.html
  28. CGA (1999) Handbook of compressed gases. Springer, New York, NYGoogle Scholar
  29. Chen CH, Xirasagar S, Lin HC (2006) Seasonality in adult asthma admissions, air pollutant levels, and climate: a population-based study. J Asthma 43(4):287–292. doi: 10.1080/02770900600622935 PubMedGoogle Scholar
  30. Chodaczek G, Bacsi A, Dharajiya N, Sur S, Hazra TK, Boldogh I (2009) Ragweed pollen-mediated IgE-independent release of biogenic amines from mast cells via induction of mitochondrial dysfunction. Mol Immunol 46(13):2505–2514PubMedGoogle Scholar
  31. Clayton GD, Clayton FE (eds) (1985) Patty’s industrial hygiene and toxicology, vol 3, 2nd edn. Wiley, New York, NYGoogle Scholar
  32. Csillag A, Boldogh I, Pazmandi K, Magyarics Z, Gogolak P, Sur S, Bacsi A (2010) Pollen-induced oxidative stress influences both innate and adaptive immune responses via altering dendritic cell functions. J Immunol 184(5):2377–2385. doi: 10.4049/jimmunol.0803938 PubMedGoogle Scholar
  33. Cui Y, Gao CQ, Sun G, Zhou Y, Qu F, Tang C, Guan C (2011) L-arginine promotes DNA repair in cultured bronchial epithelial cells exposed to ozone: involvement of the ATM pathway. Cell Biol Int 35(3):273–280. doi: 10.1042/cbi20090252 PubMedGoogle Scholar
  34. Dales RE, Cakmak S, Judek S, Dann T, Coates F, Brook JR, Burnett RT (2004) Influence of outdoor aeroallergens on hospitalization for asthma in Canada. J Allergy Clin Immunol 113(2):303–306. doi: 10.1016/j.jaci.2003.11.016 PubMedGoogle Scholar
  35. D’Amato G, Liccardi G, D’Amato M, Cazzola M (2002) Respiratory allergic diseases induced by outdoor air pollution in urban areas. Monaldi Arch Chest Dis 57(3–4):161–163PubMedGoogle Scholar
  36. Dannis ML (1974) Rubber dust from the normal wear of tires. Rubber Chem Tech 47(4):1011–1037. doi: 10.5254/1.3540458 Google Scholar
  37. Darley EF, Middleton JT, Garber MJ (1960) Plant damage and eye irritation from ozone-hydrocarbon reactions. J Agric Food Chem 8:483–485Google Scholar
  38. de Boer HE, van Elzelingen-Dekker CM, van Rheenen-Verberg CM, Spanjaard L (2006) Use of gaseous ozone for eradication of methicillin-resistant Staphylococcus aureus from the home environment of a colonized hospital employee. Infect Control Hosp Epidemiol 27(10):1120–1122. doi: 10.1086/507966 PubMedGoogle Scholar
  39. Decker H, Patton V, Scott J, Spencer N (2003) Closing the diesel divide: protecting public health from diesel air pollution. pp. 53 http://www.greenhoustontx.gov/reports/closingdieseldivide.pdf
  40. Delfino RJ, Gong H Jr, Linn WS, Pellizzari ED, Hu Y (2003) Asthma symptoms in Hispanic children and daily ambient exposures to toxic and criteria air pollutants. Environ Health Perspect 111(4):647–656PubMedGoogle Scholar
  41. Devlin RB, Raub JA, Folinsbee LJ (1997) Health effects of ozone. Sci Med May/June:8–17Google Scholar
  42. Dharajiya N, Boldogh I, Cardenas V, Sur S (2008) Role of pollen NAD(P)H oxidase in allergic inflammation. Curr Opin Allergy Clin Immunol 8(1):57–62. doi: 10.1097/ACI.0b013e3282f3b5dc PubMedGoogle Scholar
  43. Diaz-Sanchez D, Tsien A, Fleming J, Saxon A (1997) Combined diesel exhaust particulate and ragweed allergen challenge markedly enhances human in vivo nasal ragweed-specific IgE and skews cytokine production to a T helper cell 2-type pattern. J Immunol 158(5):2406–2413PubMedGoogle Scholar
  44. Dockery DW, Pope CA 3rd, Xu X, Spengler JD, Ware JH, Fay ME, Speizer FE (1993) An association between air pollution and mortality in six U.S. cities. N Engl J Med 329(24):1753–1759. doi: 10.1056/nejm199312093292401 PubMedGoogle Scholar
  45. Donaldson K, Stone V (2003) Current hypotheses on the mechanisms of toxicity of ultrafine particles. Ann Ist Super Sanita 39(3):405–410PubMedGoogle Scholar
  46. Donaldson K, Gilmour MI, MacNee W (2000) Asthma and PM10. Respir Res 1(1):12–15. doi: 10.1186/rr5 PubMedGoogle Scholar
  47. Durrani SR, Viswanathan RK, Busse WW (2011) What effect does asthma treatment have on airway remodeling? Current perspectives. J Allergy Clin Immunol 128(3):439–448. doi: 10.1016/j.jaci.2011.06.002, quiz 449–450PubMedGoogle Scholar
  48. Eghari-Sabet S, Slater JE (1993) Latex allergy: a potentially serious respiratory disorder. J Respir Dis 14:1473–1482Google Scholar
  49. EPA (1997) Air emissions from scrap tire combustion (EPA-600/R-97-115). http://www.EPA.gov
  50. EPA (2009) USEPA technology transfer network air toxics website. http://www.epa.gov/ttnatw01/hlthef/butadien.html
  51. EPA (2010a) National ambient air quality standards for ozone, 2943–3052Google Scholar
  52. EPA (2010b) Scrap tires: handbook on recycling applications and management for the US and Mexico. http://www.epa.gov/border2012/fora/waste-forum/docs/ScrapTireHandbook_US-Mexico2010-LR.pdf
  53. EPA (2012a) Ground level ozone. EPA basic information. http://www.epa.gov/glo/basic.html
  54. EPA (2012b) Health effects of ozone in patients with asthma and other chronic respiratory disease. Ozone and Your Patient’s Health: Training for Healthcare Providers. http://www.epa.gov/apti/ozonehealth/population.html
  55. EPA (2012c) Health effects of ozone in the general population. Ozone and Your Patient’s Health: Training for Healthcare Providers. http://www.epa.gov/apti/ozonehealth/population.html
  56. EPA (2012d) Sulfur dioxide (SO2) primary standards—table of historical SO2 NAAQS. http://www.epa.gov/ttn/naaqs/standards/so2/s_so2_history.html
  57. EPA (2013) Acid rain in New England: a brief history. http://www.epa.gov/region1/eco/acidrain/history.html
  58. Erbas B, Akram M, Dharmage SC, Tham R, Dennekamp M, Newbigin E, Abramson MJ (2012) The role of seasonal grass pollen on childhood asthma emergency department presentations. Clin Exp Allergy 42(5):799–805. doi: 10.1111/j.1365-2222.2012.03995.x PubMedGoogle Scholar
  59. Faroon O, Roney N, Taylor J, Ashizawa A, Lumpkin MH, Plewak DJ (2008) Acrolein environmental levels and potential for human exposure. Toxicol Ind Health 24(8):543–564. doi: 10.1177/0748233708098124 PubMedGoogle Scholar
  60. Ferng SF, Castro CE, Afifi AA, Bermudez E, Mustafa MG (1997) Ozone-induced DNA strand breaks in guinea pig tracheobronchial epithelial cells. J Toxicol Environ Health 51(4):353–367. doi: 10.1080/00984109708984030 PubMedGoogle Scholar
  61. Garg R (2001) Inorganic chemistry. Kalpaz Publications, Gyan Publishing House, New Delhi, IndiaGoogle Scholar
  62. Gergen PJ, Turkeltaub PC (1992) The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976–1980 (NHANES II). J Allergy Clin Immunol 90(4, Part 1):579–588. doi: 10.1016/0091-6749(92)90130-T PubMedGoogle Scholar
  63. Gerlofs-Nijland ME, Dormans JA, Bloemen HJ, Leseman DL, John A, Boere F, Cassee FR (2007) Toxicity of coarse and fine particulate matter from sites with contrasting traffic profiles. Inhal Toxicol 19(13):1055–1069. doi: 10.1080/08958370701626261 PubMedGoogle Scholar
  64. Ghilarducci DP, Tjeerdema RS (1995) Fate and effects of acrolein. Rev Environ Contam Toxicol 144:95–146PubMedGoogle Scholar
  65. Gilles S, Mariani V, Bryce M, Mueller MJ, Ring J, Jakob T, Traidl-Hoffmann C (2009) Pollen-derived E1-phytoprostanes signal via PPAR-gamma and NF-kappaB-dependent mechanisms. J Immunol 182(11):6653–6658. doi: 10.4049/jimmunol.0802613 PubMedGoogle Scholar
  66. Ginsberg G, Toal B, Kurland T (2011) Benzothiazole toxicity assessment in support of synthetic turf field human health risk assessment. J Toxicol Environ Health A 74(17):1175–1183. doi: 10.1080/15287394.2011.586943 PubMedGoogle Scholar
  67. Glovsky MM, Miguel AG, Cass GR (1997) Particulate air pollution: possible relevance in asthma. Allergy Asthma Proc 18(3):163–166PubMedGoogle Scholar
  68. Grant JA, Nicodemus CF, Findlay SR, Glovsky MM, Grossman J, Kaiser H et al (1995) Cetirizine in patients with seasonal rhinitis and concomitant asthma: prospective, randomized, placebo-controlled trial. J Allergy Clin Immunol 95(5 Pt 1):923–932PubMedGoogle Scholar
  69. Grech V, Balzan M, Asciak RP, Buhagiar A (2002) Seasonal variations in hospital admissions for asthma in Malta. J Asthma 39(3):263–268PubMedGoogle Scholar
  70. Grembiale RD, Camporota L, Naty S, Tranfa CM, Djukanovic R, Marsico SA (2000) Effects of specific immunotherapy in allergic rhinitic individuals with bronchial hyperresponsiveness. Am J Respir Crit Care Med 162(6):2048–2052PubMedGoogle Scholar
  71. Gualtieri M, Andrioletti M, Mantecca P, Vismara C, Camatini M (2005a) Impact of tire debris on in vitro and in vivo systems. Part Fibre Toxicol 2(1):1. doi: 10.1186/1743-8977-2-1 PubMedGoogle Scholar
  72. Gualtieri M, Rigamonti L, Galeotti V, Camatini M (2005b) Toxicity of tire debris extracts on human lung cell line A549. Toxicol In Vitro 19(7):1001–1008. doi: 10.1016/j.tiv.2005.06.038 PubMedGoogle Scholar
  73. Gualtieri M, Mantecca P, Cetta F, Camatini M (2008) Organic compounds in tire particle induce reactive oxygen species and heat-shock proteins in the human alveolar cell line A549. Environ Int 34(4):437–442. doi: 10.1016/j.envint.2007.09.010 PubMedGoogle Scholar
  74. Hamann CP (1993) Natural rubber latex protein sensitivity in review. Am J Contact Dermat 4(1):4–21Google Scholar
  75. Henderson Y, Haggard HW (1943) Noxious gases, 2nd edn. Reinhold, New York, NYGoogle Scholar
  76. Herbert V, Bisio A (1985) Synthetic rubber: a project that had to succeed. Greenwood, Westport, CTGoogle Scholar
  77. Hesterberg TW, Bunn WB 3rd, Chase GR, Valberg PA, Slavin TJ, Lapin CA, Hart GA (2006) A critical assessment of studies on the carcinogenic potential of diesel exhaust. Crit Rev Toxicol 36(9):727–776. doi: 10.1080/10408440600908821 PubMedGoogle Scholar
  78. Ho SM, Johnson A, Tarapore P, Janakiram V, Zhang X, Leung YK (2012) Environmental epigenetics and its implication on disease risk and health outcomes. ILAR J 53(3–4):289–305. doi: 10.1093/ilar.53.3-4.289 PubMedGoogle Scholar
  79. Hochman DJ, Collaco CR, Brooks EG (2012) Acrolein induction of oxidative stress and degranulation in mast cells. Environ Toxicol. doi: 10.1002/tox.21818 PubMedGoogle Scholar
  80. Hougaard KS, Jensen KA, Nordly P, Taxvig C, Vogel U, Saber AT, Wallin H (2008) Effects of prenatal exposure to diesel exhaust particles on postnatal development, behavior, genotoxicity and inflammation in mice. Part Fibre Toxicol 5:3. doi: 10.1186/1743-8977-5-3 PubMedGoogle Scholar
  81. Jacobsen L, Nuchel Petersen B, Wihl JA, Lowenstein H, Ipsen H (1997) Immunotherapy with partially purified and standardized tree pollen extracts. IV. Results from long-term (6-year) follow-up. Allergy 52(9):914–920PubMedGoogle Scholar
  82. Jacobsen L, Niggemann B, Dreborg S, Ferdousi HA, Halken S, Host A, Moller C (2007) Specific immunotherapy has long-term preventive effect of seasonal and perennial asthma: 10-year follow-up on the PAT study. Allergy 62(8):943–948. doi: 10.1111/j.1398-9995.2007.01451.x PubMedGoogle Scholar
  83. Jerrett M, Burnett RT, Pope CA 3rd, Ito K, Thurston G, Krewski D, Thun M (2009) Long-term ozone exposure and mortality. N Engl J Med 360(11):1085–1095. doi: 10.1056/NEJMoa0803894 PubMedGoogle Scholar
  84. Johansson SG, Bennich H (1969) Serum immunoglobulin (IgE) levels in asthma. Thorax 24(4):510PubMedGoogle Scholar
  85. Johnstone DE, Dutton A (1968) The value of hyposensitization therapy for bronchial asthma in children–a 14-year study. Pediatrics 42(5):793–802PubMedGoogle Scholar
  86. Kao C-C, Huang J-L, Ou L-S, See L-C (2005) The prevalence, severity and seasonal variations of asthma, rhinitis and eczema in Taiwanese schoolchildren. Pediatr Allergy Immunol 16(5):408–415. doi: 10.1111/j.1399-3038.2005.00268.x PubMedGoogle Scholar
  87. Kehrl HR, Peden DB, Ball B, Folinsbee LJ, Horstman D (1999) Increased specific airway reactivity of persons with mild allergic asthma after 7.6 hours of exposure to 0.16 ppm ozone. J Allergy Clin Immunol 104(6):1198–1204PubMedGoogle Scholar
  88. Kerzel S, Dehne J, Rogosch T, Schaub B, Maier RF, Zemlin M (2012a) T(H)17 cell frequency in peripheral blood from children with allergic asthma correlates with the level of asthma control. J Pediatr. doi: 10.1016/j.jpeds.2012.07.051 PubMedGoogle Scholar
  89. Kerzel S, Dehne J, Rogosch T, Schaub B, Maier RF, Zemlin M (2012b) TH17 cell frequency in peripheral blood from children with allergic asthma correlates with the level of asthma control. J Pediatr 161(6):1172–1174. doi: 10.1016/j.jpeds.2012.07.051 PubMedGoogle Scholar
  90. Knox RB, Suphioglu C, Taylor P, Desai R, Watson HC, Peng JL, Bursill LA (1997) Major grass pollen allergen Lol p 1 binds to diesel exhaust particles: implications for asthma and air pollution. Clin Exp Allergy 27(3):246–251PubMedGoogle Scholar
  91. Kobayashi T (2000) Exposure to diesel exhaust aggravates nasal allergic reaction in guinea pigs. Am J Respir Crit Care Med 162(2 Pt 1):352–356. doi: 10.1164/ajrccm.162.2.9809035 PubMedGoogle Scholar
  92. Kool M, Hammad H, Lambrecht BN (2012) Cellular networks controlling Th2 polarization in allergy and immunity. F1000 Biol Rep 4:6. doi: 10.3410/b4-6 PubMedGoogle Scholar
  93. Koster ES, Raaijmakers JA, Vijverberg SJ, van der Ent CK, Maitland-van der Zee AH (2011) Asthma symptoms in pediatric patients: differences throughout the seasons. J Asthma 48(7):694–700. doi: 10.3109/02770903.2011.601780 PubMedGoogle Scholar
  94. Krishnaswamy G, Kelley J, Johnson D, Youngberg G, Stone W, Huang SK, Chi DS (2001) The human mast cell: functions in physiology and disease. Front Biosci 6:D1109–D1127PubMedGoogle Scholar
  95. Kumar L, Newcomb RW, Hornbrook M (1971) A year-round study of serum IgE levels in asthmatic children. J Allergy Clin Immunol 48(5):305–312PubMedGoogle Scholar
  96. Lambrecht BN, Hammad H (2012) The airway epithelium in asthma. Nat Med 18(5):684–692. doi: 10.1038/nm.2737 PubMedGoogle Scholar
  97. Langier S, Sade K, Kivity S (2012) Regulatory T Cells in allergic asthma. IMAJ 14:180–183PubMedGoogle Scholar
  98. Lawther PJ, Macfarlane AJ, Waller RE, Brooks AG (1975) Pulmonary function and sulphur dioxide, some preliminary findings. Environ Res 10(3):355–367PubMedGoogle Scholar
  99. Lee IT, Yang CM (2012) Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol 84(5):581–590. doi: 10.1016/j.bcp.2012.05.005 PubMedGoogle Scholar
  100. Lee GB, Brandt EB, Xiao C, Gibson AM, Le Cras TD, Brown LA, Khurana Hershey GK (2013) Diesel exhaust particles induce cysteine oxidation and s-glutathionylation in house dust mite induced murine asthma. PLoS One 8(3):e60632. doi: 10.1371/journal.pone.0060632 PubMedGoogle Scholar
  101. Lemanske RF Jr, Busse WW (2010) Asthma: clinical expression and molecular mechanisms. J Allergy Clin Immunol 125(2 Suppl 2):S95–S102. doi: 10.1016/j.jaci.2009.10.047 PubMedGoogle Scholar
  102. Li L, Holian A (1998) Acrolein: a respiratory toxin that suppresses pulmonary host defense. Rev Environ Health 13(1–2):99–108PubMedGoogle Scholar
  103. Li L, Hamilton RF Jr, Taylor DE, Holian A (1997) Acrolein-induced cell death in human alveolar macrophages. Toxicol Appl Pharmacol 145(2):331–339. doi: 10.1006/taap.1997.8189 PubMedGoogle Scholar
  104. Li L, Hamilton RF Jr, Holian A (1999) Effect of acrolein on human alveolar macrophage NF-kappaB activity. Am J Physiol 277(3 Pt 1):L550–L557PubMedGoogle Scholar
  105. Lin S, Hwang SA, Pantea C, Kielb C, Fitzgerald E (2004) Childhood asthma hospitalizations and ambient air sulfur dioxide concentrations in Bronx County, New York. Arch Environ Health 59(5):266–275. doi: 10.3200/aeoh.59.5.266-275 PubMedGoogle Scholar
  106. Linn WS, Avol EL, Shamoo DA, Spier CE, Valencia LM, Venet TG, Hackney JD (1986) A dose–response study of healthy, heavily exercising men exposed to ozone at concentrations near the ambient air quality standard. Toxicol Ind Health 2(1):99–112PubMedGoogle Scholar
  107. Lordan JL, Bucchieri F, Richter A, Konstantinidis A, Holloway JW, Thornber M, Davies DE (2002) Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells. J Immunol 169(1):407–414PubMedGoogle Scholar
  108. McClurkin JD, Maier DE (2010) Half-life time of ozone as a function of air conditions and movement. Copenhagen, DenmarkGoogle Scholar
  109. Miguel AG, Cass GR, Weiss J, Glovsky MM (1996) Latex allergens in tire dust and airborne particles. Environ Health Perspect 104(11):1180–1186PubMedGoogle Scholar
  110. Mizutani N, Goshima H, Nabe T, Yoshino S (2012) Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice. J Immunol 188(11):5694–5705. doi: 10.4049/jimmunol.1103176 PubMedGoogle Scholar
  111. Moldoveanu SC, Coleman W, Wilkins J (2007) Determination of carbonyl compounds in exhaled cigarette smoke. Beitr Tabakforsch Int 22:346–357Google Scholar
  112. Morawska L, He C, Johnson G, Jayaratne R, Salthammer T, Wang H, Wensing M (2009) An investigation into the characteristics and formation mechanisms of particles originating from the operation of laser printers. Environ Sci Technol 43(4):1015–1022PubMedGoogle Scholar
  113. Nelson HS, Szefler SJ, Jacobs J, Huss K, Shapiro G, Sternberg AL (1999) The relationships among environmental allergen sensitization, allergen exposure, pulmonary function, and bronchial hyperresponsiveness in the Childhood Asthma Management Program. J Allergy Clin Immunol 104(4):775–785. doi: 10.1016/S0091-6749(99)70287-3 PubMedGoogle Scholar
  114. NIOSH (2010) NIOSH pocket guide to chemical hazards. http://www.cdc.gov/niosh/npg/npgd0575.html
  115. Novembre E, Galli E, Landi F, Caffarelli C, Pifferi M, De Marco E, Vierucci A (2004) Coseasonal sublingual immunotherapy reduces the development of asthma in children with allergic rhinoconjunctivitis. J Allergy Clin Immunol 114(4):851–857. doi: 10.1016/j.jaci.2004.07.012 PubMedGoogle Scholar
  116. NRC (1981) Formaldehyde and other aldehydes. National Academy Press, National Research Council, Washington, DCGoogle Scholar
  117. OEHHA (2001) Prioritization of toxic air contaminants-children’s environmental health protection act: acrolein. http://www.oehha.org/air/toxic_contaminants/pdf_zip/Acrolein_final.pdf
  118. Pandya RJ, Solomon G, Kinner A, Balmes JR (2002) Diesel exhaust and asthma: hypotheses and molecular mechanisms of action. Environ Health Perspect 110(Suppl 1):103–112PubMedGoogle Scholar
  119. Peden DB (1997) Mechanisms of pollution-induced airway disease: in vivo studies. Allergy 52(38 Suppl):37–44, discussion 57–38PubMedGoogle Scholar
  120. Pierson WR, Brachaczek WW (1974) Airborne particulate debris from rubber tires. Rubber Chem Tech 47(5):1275–1299. doi: 10.5254/1.3540499 Google Scholar
  121. Platts-Mills TA (2001) The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med 164(8 Pt 2):S1–S5PubMedGoogle Scholar
  122. Plotz SG, Traidl-Hoffmann C, Feussner I, Kasche A, Feser A, Ring J, Behrendt H (2004) Chemotaxis and activation of human peripheral blood eosinophils induced by pollen-associated lipid mediators. J Allergy Clin Immunol 113(6):1152–1160. doi: 10.1016/j.jaci.2004.03.011 PubMedGoogle Scholar
  123. Pohanish RP (2004) HazMat data: for first response, transportation, storage, and security. Wiley-Interscience, New York, NYGoogle Scholar
  124. Redier H, Chanez P, De Vos C, Rifai N, Clauzel AM, Michel FB, Godard P (1992) Inhibitory effect of cetirizine on the bronchial eosinophil recruitment induced by allergen inhalation challenge in allergic patients with asthma. J Allergy Clin Immunol 90(2):215–224PubMedGoogle Scholar
  125. Reid MJ, Moss RB, Hsu Y-P, Kwasnicki JM, Commerford TM, AND Nelson BL (1986) Seasonal asthma in northern California: allergic causes and efficacy of immunotherapy. J Allergy Clin Immunol 78(4, Part 1):590–600. doi: 10.1016/0091-6749(86)90076-X PubMedGoogle Scholar
  126. Ristovski ZD, Miljevic B, Surawski NC, Morawska L, Fong KM, Goh F, Yang IA (2012) Respiratory health effects of diesel particulate matter. Respirology 17(2):201–212. doi: 10.1111/j.1440-1843.2011.02109.x PubMedGoogle Scholar
  127. Roberts G, Hurley C, Turcanu V, Lack G (2006) Grass pollen immunotherapy as an effective therapy for childhood seasonal allergic asthma. J Allergy Clin Immunol 117(2):263–268. doi: 10.1016/j.jaci.2005.09.054 PubMedGoogle Scholar
  128. Röschmann K, Farhat K, König P, Suck R, Ulmer AJ, Petersen A (2009) Timothy grass pollen major allergen Phl p 1 activates respiratory epithelial cells by a non-protease mechanism. Clin Exp Allergy 39(9):1358–1369. doi: 10.1111/j.1365-2222.2009.03291.x PubMedGoogle Scholar
  129. Rudell B, Sandstrom T, Stjernberg N, Heldman KB (1990) Controlled diesel exhaust exposure in an exposure chamber: pulmonary effects investigated with bronchoalveolar lavage. J Aerosol Sci 21:S411–S414Google Scholar
  130. Saha K, Kulpati DD, Padmini R, Shivpuri DN, Shali PL (1975) A study of serum immunoglobulins including IgE and reaginic antibodies in patients with bronchial asthma in relation to the spectrum of the disease. Clin Allergy 5(3):339–349PubMedGoogle Scholar
  131. Saito T (1989) Determination of styrene-butadiene and isoprene tire tread rubbers in piled particulate matter. J Anal Appl Pyrolysis 15:227–235. doi: 10.1016/0165-2370(89)85036-3 Google Scholar
  132. Saiyasitpanich P, Keener TC, Lu M, Khang SJ, Evans DE (2006) Collection of ultrafine diesel particulate matter (DPM) in cylindrical single-stage wet electrostatic precipitators. Environ Sci Technol 40(24):7890–7895PubMedGoogle Scholar
  133. Salvi S, Holgate ST (1999) Mechanisms of particulate matter toxicity. Clin Exp Allergy 29(9):1187–1194PubMedGoogle Scholar
  134. Schwarze PE, Totlandsdal AI, Lag M, Refsnes M, Holme JA, Ovrevik J (2013) Inflammation-related effects of diesel engine exhaust particles: studies on lung cells in vitro. Biomed Res Int 2013:685142. doi: 10.1155/2013/685142 PubMedGoogle Scholar
  135. Schwela D (2000) Air pollution and health in urban areas. Rev Environ Health 15(1–2):13–42PubMedGoogle Scholar
  136. Sci-Link (1995) Ozone: a sourcebook for teaching about 03 in the troposphere and stratosphere. Kendall/Hunt, Dubuque, IAGoogle Scholar
  137. Sears MR, Burrows B, Flannery EM, Herbison GP, Hewitt CJ, Holdaway MD (1991) Relation between airway responsiveness and serum IgE in children with asthma and in apparently normal children. N Engl J Med 325(15):1067–1071. doi: 10.1056/nejm199110103251504 PubMedGoogle Scholar
  138. Sim VM, Pattle RE (1957) Effect of possible smog irritants on human subjects. J Am Med Assoc 165(15):1908–1913PubMedGoogle Scholar
  139. Solutions O (2013) Questions and answers about ozone: how long does the ozone last? http://www.ozoneapplications.com/products/Residential/q&a_ozone.htm
  140. Steinberg JJ, Gleeson JL, Gil D (1990) The pathobiology of ozone-induced damage. Arch Environ Health 45(2):80–87. doi: 10.1080/00039896.1990.9935930 PubMedGoogle Scholar
  141. Stevens JF, Maier CS (2008) Acrolein: sources, metabolism, and biomolecular interactions relevant to human health and disease. Mol Nutr Food Res 52(1):7–25. doi: 10.1002/mnfr.200700412 PubMedGoogle Scholar
  142. Suarez CJ, Parker NJ, Finn PW (2008) Innate immune mechanism in allergic asthma. Curr Allergy Asthma Rep 8(5):451–459PubMedGoogle Scholar
  143. Sunyer J, Anto JM, Sabria J, Roca J, Morell F, Rodriguez-Roisin R, Rodrigo MJ (1995) Relationship between serum IgE and airway responsiveness in adults with asthma. J Allergy Clin Immunol 95(3):699–706PubMedGoogle Scholar
  144. Sykes A, Johnston SL (2008) Etiology of asthma exacerbations. J Allergy Clin Immunol 122(4):685–688. doi: 10.1016/j.jaci.2008.08.017 PubMedGoogle Scholar
  145. TOXNET: Hazardous Substances Data Bank (HSDB) (2013) http://toxnet.nlm.nih.gov/
  146. Traidl-Hoffmann C, Mariani V, Hochrein H, Karg K, Wagner H, Ring J, Behrendt H (2005) Pollen-associated phytoprostanes inhibit dendritic cell interleukin-12 production and augment T helper type 2 cell polarization. J Exp Med 201(4):627–636. doi: 10.1084/jem.20041065 PubMedGoogle Scholar
  147. Verstraelen S, Bloemen K, Nelissen I, Witters H, Schoeters G, Van Den Heuvel R (2008) Cell types involved in allergic asthma and their use in in vitro models to assess respiratory sensitization. Toxicol In Vitro 22(6):1419–1431. doi: 10.1016/j.tiv.2008.05.008 PubMedGoogle Scholar
  148. Verstraelen S, Nelissen I, Hooyberghs J, Witters H, Schoeters G, Van Cauwenberge P, Van Den Heuvel R (2009) Gene profiles of a human alveolar epithelial cell line after in vitro exposure to respiratory (non-)sensitizing chemicals: identification of discriminating genetic markers and pathway analysis. Toxicol Lett 185(1):16–22. doi: 10.1016/j.toxlet.2008.11.017 PubMedGoogle Scholar
  149. Weathers KC, Likens GE (2006) Acid rain. In: Rom WN (ed) Environmental and occupational medicine, 4th edn. Lippincott-Raven, Philadelphia, PA, pp 1549–1561Google Scholar
  150. Weiss KB (1990) SEasonal trends in us asthma hospitalizations and mortality. JAMA 263(17):2323–2328. doi: 10.1001/jama.1990.03440170045034 PubMedGoogle Scholar
  151. WHO (2000) Air quality guidelines sulfur dioxide, 2nd edn. WHO Regional Office for Europe, Copenhagen, Denmark, pp 1–12Google Scholar
  152. Wichmann HE (2007) Diesel exhaust particles. Inhal Toxicol 19(Suppl 1):241–244. doi: 10.1080/08958370701498075 PubMedGoogle Scholar
  153. Wik A, Dave G (2009) Occurrence and effects of tire wear particles in the environment–a critical review and an initial risk assessment. Environ Pollut 157(1):1–11. doi: 10.1016/j.envpol.2008.09.028 PubMedGoogle Scholar
  154. Williams PB, Buhr MP, Weber RW, Volz MA, Koepke JW, Selner JC (1995) Latex allergen in respirable particulate air pollution. J Allergy Clin Immunol 95(1 Pt 1):88–95PubMedGoogle Scholar
  155. Wills-Karp M, Nathan A, Page K, Karp CL (2010) New insights into innate immune mechanisms underlying allergenicity. Mucosal Immunol 3(2):104–110. doi: 10.1038/mi.2009.138 PubMedGoogle Scholar
  156. Xirasagar S, Lin H-C, Liu T-C (2006) Seasonality in pediatric asthma admissions: the role of climate and environmental factors. Eur J Pediatr 165(11):747–752. doi: 10.1007/s00431-006-0164-6 PubMedGoogle Scholar
  157. Zhao J, Lloyd CM, Noble A (2012) Th17 responses in chronic allergic airway inflammation abrogate regulatory T-cell-mediated tolerance and contribute to airway remodeling. Mucosal Immunol. doi: 10.1038/mi.2012.76 PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Kristin Sokol
    • 1
    • 2
  • Sanjiv Sur
    • 1
    • 2
  • Bill T. Ameredes
    • 3
    • 2
    Email author
  1. 1.Division of Allergy and ImmunologyUniversity of Texas Medical BranchGalvestonUSA
  2. 2.Department of Internal MedicineUniversity of Texas Medical BranchGalvestonUSA
  3. 3.Division of Pulmonary and Critical Care MedicineUniversity of Texas Medical BranchGalvestonUSA

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