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Conclusions and Future Directions

  • William J. Calhoun
  • Allan R. Brasier
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 795)

Abstract

Considerable variation exists in the clinical expression of asthma. As detailed in the corresponding section of this monograph, the heterogeneity of asthma is expressed clinically, by commonly observable characteristics, but these clinical phenotypes overlap and have indistinct borders. By a variety of assessment technologies and approaches (epidemiologic, physiologic, and clinical), this syndromic disease defies clear and unambiguous classification. Collectively, clinical phenotyping has not led to reliable categories of asthma that inform treatment, predict progression of lung function abnormalities, or define risk for exacerbations and death. It is for this reason that—omics approaches have been explored, and by which new stratagems for molecular phenotyping have been developed.

Keywords

Translational Research Personalized Medicine Lung Function Abnormality Indistinct Border Academic Health Care 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • William J. Calhoun
    • 1
  • Allan R. Brasier
    • 2
  1. 1.Department of Internal MedicineUniversity of Texas Medical BranchGalvestonUSA
  2. 2.University of Texas Medical BranchGalvestonUSA

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