• John E. WiktorowiczEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 795)


Although broadly defined in the literature, for the purpose of this section, we define systems biology as the description of the dynamic genomic, proteomic, and metabolomic processes integrated into a functional model of the cell, organelle, or tissue that is capable of accurately tracking the biological system’s response to environmental perturbations. The goal of this section is to complete the tripartite description of asthma systems biology, initiated by the previous section (Section II: Genetics and Genomics of Asthma), by reviewing the recent literature—the types and methods of sample collection, processing, analysis, and instrumentation—of metabolomic and proteomic investigations, including functional proteomic studies of the asthma innate immune response and glucocorticoid (GC) receptor signaling with reference to GC resistance in severe asthma.


Proteomics Sample prep Size-exclusion chromatography Asthma Airway inflammation Broncoalveolar lavage Epithelial lining fluid Induced sputum Exhaled breath condensate Bronchoscopic microsampling 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department Biochemistry and Molecular BiologyThe University of Texas Medical BranchGalvestonUSA

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