Skip to main content

Abstract

Compartment syndrome (CS) is one of the true surgical emergencies in orthopaedic trauma, and the sequelae of a missed diagnosis can have serious implications. The development of a CS begins at the microvascular level with disruption of the homeostatic environment between venous pressure, arterial flow, and intracompartmental tissue pressure. While the pathophysiology has been previously described in the literature, there remain diagnostic challenges and some question regarding the clinical utility and reliability of clinical symptoms and the physical exam—particularly in the compromised, obtunded, or pediatric patient. Early and complete fasciotomy has been shown to decrease the rates of adverse complications, however is not without some morbidity. Some of the challenges and newer diagnostic modalities in the identification of CS are reviewed as well as different fasciotomy techniques and other important concepts in the pathophysiology, outcomes, and medicolegal implications of this condition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Volkmann RV. Die ischaemischen muskellahmungen und kontrackuren. Zentralb F Chir. 1881;8:80–1.

    Google Scholar 

  2. Peterson F. Über ischämische Muskellahmung. Arch Klin Chir. 1888;37:675–7.

    Google Scholar 

  3. Jones R. Volkmann’s ischaemic contracture with special reference to treatment. Br Med J. 1928;2:639–42.

    Article  PubMed  CAS  Google Scholar 

  4. Leriche R. Surgery of the sympathetic system: indications and results. Ann Surg. 1928;883:449–69.

    Google Scholar 

  5. Griffiths DL. Volkmann’s ischaemic contracture. Br J Surg. 1940;28:239–60.

    Article  Google Scholar 

  6. Murphy JB. Myositis. J Am Med Ass. 1914;63:1249.

    Google Scholar 

  7. Vogt PR. Ischaemic muscle necrosis following marching. Unpublished, but read before the Oregon State Medical Society 4 Sept 1943.

    Google Scholar 

  8. Hughes JR. Ischaemic necrosis of the anterior tibial muscles due to fatigue. J Bone Joint Surg Br. 1948;30-B:581–94.

    Google Scholar 

  9. Mavor GE. The anterior tibial syndrome. J Bone Joint Surg Br. 1956;38-B:513–7.

    PubMed  CAS  Google Scholar 

  10. Ellis H. Disabilities after tibial shaft fractures: with special reference to Volkmanns ischaemic contracture. J Bone Joint Surg Br. 1958;40-B:190–6.

    PubMed  CAS  Google Scholar 

  11. MacGowan W. Acute ischaemia complicating limb trauma. J Bone Joint Surg Br. 1968;50-B:472–81.

    Google Scholar 

  12. Seddon HJ. Volkmann’s ischaemia in the lower limb. J Bone Joint Surg Br. 1966;48-B:627–36.

    Google Scholar 

  13. Matsen F. Compartmental syndrome, an unified concept. Clin Orthop. 1975;113:8–14.

    Article  PubMed  Google Scholar 

  14. Landerer AS. Die gewebspannung in ihrem einfluss auf die ortliche blutbewegung und lymphbewgung. Leipzig: Vogel; 1884.

    Google Scholar 

  15. Starling EH. On the absorption of fluids from connective tissue spaces. J Physiology (London). 1896;19:312–26.

    CAS  Google Scholar 

  16. McQueen MM, Gaston P, Court-Brown CM. Acute compartment syndrome: who is at risk? J Bone Joint Surg Br. 2000;82:200–3.

    Article  PubMed  CAS  Google Scholar 

  17. McQueen MM, Christie J, Court-Brown CM. Acute compartment syndrome in tibial diaphyseal fractures. J Bone Joint Surg Br. 1996;78:95–8.

    PubMed  CAS  Google Scholar 

  18. McQueen MM, Court-Brown CM. Compartment monitoring in tibial fractures: the pressure threshold for decompression. J Bone Joint Surg Br. 1996;78:99–104.

    PubMed  CAS  Google Scholar 

  19. Mubarak SJ. Technique of diagnosis and treatment of the lower extremity compartment syndromes in children. Oper Tech Orthop. 1995;5:178–89.

    Article  Google Scholar 

  20. Gulli B, Templeman D. Compartment syndrome of the lower extremity. Orthop Clin North Am. 1994;25:677–84.

    PubMed  CAS  Google Scholar 

  21. Ouellette EA. Compartment syndromes in obtunded patients. Hand Clin. 1998;14:431–50.

    PubMed  CAS  Google Scholar 

  22. Janzing H, Broos P, Rommens P. Compartment syndrome as a complication of skin traction in children with femoral fractures. J Trauma. 1996;41:156–8.

    Article  PubMed  CAS  Google Scholar 

  23. Templeman D, Lange R, Harms B. Lower-extremity compartment syndromes associated with use of pneumatic antishock garments. J Trauma. 1987;27:79–81.

    Article  PubMed  CAS  Google Scholar 

  24. Slater Jr RR, Weiner TM, Koruda MJ. Bilateral leg compartment syndrome complicating prolonged lithotomy position. Orthopedics. 1994;17:954–9.

    PubMed  Google Scholar 

  25. Goldsmith AL, McCallum MI. Compartment syndrome as a complication of the prolonged use of the Lloyd-Davies position. Anaesthesia. 1996;51:1048–52.

    Article  PubMed  CAS  Google Scholar 

  26. Velmahos GC, Toutouzas KG. Vascular trauma and compartment syndromes. Surg Clin North Am. 2002;82:125–41.

    Article  PubMed  Google Scholar 

  27. Shakespeare DT, Henderson NJ. Compartmental pressure changes during calcaneal traction in tibial fractures. J Bone Joint Surg Br. 1982;64:498–9.

    PubMed  CAS  Google Scholar 

  28. Weiner G, Styf J, Nakhostine M, Gershuni DH. Effect of ankle position and a plaster cast on intramuscular pressure in the human leg. J Bone Joint Surg Am. 1994;76:1476–81.

    PubMed  CAS  Google Scholar 

  29. Moed BR, Strom DE. Compartment syndrome after closed intramedullary nailing of the tibia: a canine model and report of two cases. J Orthop Trauma. 1991;5:71–7.

    Article  PubMed  CAS  Google Scholar 

  30. Tornetta III P, French BG. Compartment pressures during nonreamed tibial nailing without traction. J Orthop Trauma. 1997;11:24–7.

    Article  PubMed  Google Scholar 

  31. Frink M, Kalus AK, Kuther G, et al. Long-term results of compartment syndrome of the lower limb in polytraumatised patients. Injury. 2007;38:607–13.

    Article  PubMed  Google Scholar 

  32. Harrington P, Bunola J, Jennings AJ, et al. Acute compartment syndrome masked by intravenous morphine from a patient-controlled analgesia pump. Injury. 2000;31:387–9.

    Article  PubMed  CAS  Google Scholar 

  33. Mar GJ, Barrington MJ, McGuirk BR. Acute compartment syndrome of the lower limb and the effect of postoperative analgesia on diagnosis. Br J Anaesth. 2009;102:3–11.

    Article  PubMed  CAS  Google Scholar 

  34. Mubarak SJ, Wilton NC. Compartment syndromes and epidural analgesia. J Pediatr Orthop. 1997;17:282–4.

    PubMed  CAS  Google Scholar 

  35. Blaisdell FW. The pathophysiology of skeletal muscle ischemia and the reperfusion syndrome: a review. Cardiovasc Surg. 2002;10:620–30.

    Article  PubMed  Google Scholar 

  36. Sanderson RA, Foley RK, McIvor GWD, et al. Histological response on skeletal muscle to ischemia. Clin Orthop. 1975;113:27–34.

    Article  PubMed  Google Scholar 

  37. Bowden RE, Gutmann E. The fate of voluntary muscle after vascular injury in man. J Bone Joint Surg. 1949;31B:356, 19.

    CAS  Google Scholar 

  38. Lindsay T, Liauw S, Romaschin AD, Walker PM. The effect of ischemia/reperfusion on adenine nucleotide metabolism and xanthine oxidase production in skeletal muscle. J Vasc Surg. 1990;12(1):8–15.

    PubMed  CAS  Google Scholar 

  39. Nario CV. La enfermedad de Volkman experimental. Ann Fac Med Montivideo. 1938;10:87–128.

    Google Scholar 

  40. Court-Brown CM, McQueen MM. Compartment syndrome delays tibial union. Acta Orthop Scand. 1987;58:249–52.

    Article  PubMed  CAS  Google Scholar 

  41. Delee JC, Stiehl JB. Open tibia fracture with compartment syndrome. Clin Orthop. 1981;160:175–84.

    PubMed  Google Scholar 

  42. Hargens AR, Akeson WH, Mubarak SJ, et al. Fluid balance within the canine anterolateral compartment and its relationship to compartment syndromes. J Bone Joint Surg Am. 1978;60:499–505.

    PubMed  CAS  Google Scholar 

  43. Matava MJ, Whitesides Jr TE, Seiler III JG, Hewan-Lowe K, Hutton WC. Determination of the compartment pressure threshold of muscle ischemia in a canine model. J Trauma. 1994;37:50–8.

    Article  PubMed  CAS  Google Scholar 

  44. Shuler FD, Dietz MJ. Physicians’ ability to manually detect isolated elevations in leg intracompartmental pressure. J Bone Joint Surg Am. 2010;92:361–7.

    Article  PubMed  Google Scholar 

  45. Bradley EL. The anterior tibial compartment syndrome. Surg Gynaecol Obstet. 1973;136:289–97.

    Google Scholar 

  46. Whitesides Jr TE, Haney TC, Morimoto K, Harada H. Tissue pressure measurements as a determinant for the need of fasciotomy. Clin Orthop. 1975;113:43–51.

    Article  PubMed  Google Scholar 

  47. Blick SS, Brumback RJ, Poka A, Burgess AR, Ebraheim NA. Compartment syndrome in open tibial fractures. J Bone Joint Surg Am. 1986;68-A:1348–53.

    Google Scholar 

  48. Hargens AR, Akeson WH, Mubarak SJ, et al. Tissue fluid pressures: from basic research tools to clinical applications. J Orthop Res. 1989;7:902–9.

    Article  PubMed  CAS  Google Scholar 

  49. Matsen III FA, Winquist RA, Krugmire Jr RB. Diagnosis and management of compartmental syndromes. J Bone Joint Surg Am. 1980;62:286–91.

    PubMed  Google Scholar 

  50. Mubarak J, Owen A, Hargen R, Garetto P, Akeson H. Acute compartment syndromes: diagnosis and treatment with the aid of the wick catheter. J Bone Joint Surg. 1978;60-A:1091–5.

    Google Scholar 

  51. Kakar S, Firoozabadi R, McKean J, Tornetta 3rd P. Diastolic blood pressure in patients with tibia fractures under anaesthesia: Implications for the diagnosis of compartment syndrome. J Orthop Trauma. 2007;21:99–103.

    Article  PubMed  Google Scholar 

  52. Prayson MJ, Chen JL, Hampers D, Vogt M, Fenwick J, Meredick R. Baseline compartment pressure measurements in isolated lower extremity fractures without clinical compartment syndrome. J Trauma. 2006;60:1037–40.

    Article  PubMed  Google Scholar 

  53. Harris IA, Kadir A, Donald G. Continuous compartment pressure monitoring for tibia fractures: does it influence outcome? J Trauma. 2006;60:1330–5.

    Article  PubMed  Google Scholar 

  54. Moed BR, Thorderson PK. Measurement of ICP: a comparison of the slit catheter, side-ported needle, and simple needle. J Bone Joint Surg Am. 1993;75:231–5.

    PubMed  CAS  Google Scholar 

  55. Heckman MM, Whitesides TE, Greive SR, et al. Compartment pressure in association with closed tibial fractures. The relationship between tissue pressure, compartment and the distance from the site of the fracture. J Bone Joint Surg Am. 1994;76:1285–92.

    PubMed  CAS  Google Scholar 

  56. Shuler MS, Reisman WM, Kinsey TL, Whitesides Jr TE, Hammerberg EM, Davila MG, Moore TJ. Correlation between muscle oxygenation and compartment pressures in acute compartment syndrome of the leg. J Bone Joint Surg Am. 2010;92:863–70.

    Article  PubMed  Google Scholar 

  57. Lampert R, Weih EH, Breucking E, et al. Postoperative bilateral compartment syndrome resulting from prolonged urological surgery in lithotomy position. Serum creatine kinase activity CK as a warning signal in sedated, artificially respirated patients. Anaesthesist. 1995;44:43–7.

    Article  PubMed  CAS  Google Scholar 

  58. Van Nieuwenhoven FA, Kleine AH, Wodzig KWH. Discrimination between myocardial and skeletal muscle injury by assessment of the plasma ratio of myoglobin over fatty acid-binding protein. Circulation. 1995;92:2848–54.

    Article  PubMed  Google Scholar 

  59. Zapico-Muniz E, Santalo-Bel M, Merce-Muntanola J, et al. Ischemia modified albumin during skeletal muscle ischemia. Clin Chem. 2004;50:1063–5.

    Article  PubMed  CAS  Google Scholar 

  60. Edwards PD, Miles KA, Owens SJ, et al. A new non-invasive test for the detection of compartment syndromes. Nucl Med Commun. 1999;20:215–8.

    Article  PubMed  CAS  Google Scholar 

  61. Elliott KGB, Johnstone AJ. Diagnosing acute compartment syndrome. J Bone Joint Surg Br. 2003;85-B:625–32.

    Google Scholar 

  62. Abraham P, Leftheriotis G, Saumet JL. Laser Doppler flowmetry in the diagnosis of chronic compartment syndrome. J Bone Joint Surg Br. 1998;80:365–9.

    Article  PubMed  CAS  Google Scholar 

  63. Sheridan GW, Matsen III FA, Krugmire Jr RB. Further investigations on the pathophysiology of the compartmental syndrome. Clin Orthop Relat Res. 1977;123:266–70.

    PubMed  Google Scholar 

  64. Styf J. Compartment syndromes diagnosis, treatment and complications. Boca Raton: CRC Press LLC; 2004.

    Google Scholar 

  65. Garfin SR, Mubarak SJ, Evans KL, et al. Quantification of intracompartmental pressure and volume under plaster casts. J Bone Joint Surg Am. 1981;63A:449–53.

    Google Scholar 

  66. Younger ASE, Curran P, McQueen MM. Backslabs and plaster casts: which will best accommodate increasing intracompartmental pressures? Injury. 1990;21:178–81.

    Article  Google Scholar 

  67. Matsen FA, Wyss CR, Krugmire RB, et al. The effect of limb elevation and dependency on local arteriovenous gradients in normal human limbs with particular reference to limbs with increased tissue pressure. Clin Orthop. 1980;150:187–95.

    PubMed  Google Scholar 

  68. Gaspard DJ, Kohl RD. Compartmental syndromes in which skin is the limiting boundary. Clin Orthop. 1975;113:65–8.

    Article  PubMed  Google Scholar 

  69. Cohen MS, Garfin SR, Hargens AR, Mubarak SJ. Acute compartment syndrome: effect of dermotomy on fascial decompression in the leg. J Bone Joint Surg Br. 1991;73:287–90.

    PubMed  CAS  Google Scholar 

  70. Mandi A, Weber TG. Fasciotomy of the foot: an anatomical study with special reference to release of the calcaneal compartment. Foot Ankle. 1990;10:267–75.

    Article  Google Scholar 

  71. Henry AK. Extensile exposure. 2nd ed. Baltimore: Williams & Wilkins; 1963. p. 300–8.

    Google Scholar 

  72. Havig MT, Leversedge FJ, Seiler JG. Forearm compartment pressures: an in vitro analysis of open and endoscopic fasciotomy. J Hand Surg Am. 1999;24:1289–97.

    Article  PubMed  CAS  Google Scholar 

  73. Webb LX. New techniques in wound management: vacuum-assisted wound closure. J Am Acad Orthop Surg. 2002;10:303–11.

    PubMed  Google Scholar 

  74. Janzing H, Broos P. Dermotraction: an effective technique for the closure of fasciotomy: a preliminary report of 15 patients. J Orthop Trauma. 2001;15:438–41.

    Article  PubMed  CAS  Google Scholar 

  75. McQueen MM. The effect of acute compartment syndrome on bone blood flow and bone union. MD thesis, University of Edinburgh; 1995.

    Google Scholar 

  76. Finkelstein JA, Hunter GA, Hu RW. Lower limb compartment syndrome: course after delayed fasciotomy. J Trauma. 1996;40:342–4.

    Article  PubMed  CAS  Google Scholar 

  77. Reis ND, Michaelson M. Crush injury to the lower limbs. Treatment of the local injury. J Bone Joint Surg Am. 1986;68:414–8.

    PubMed  CAS  Google Scholar 

  78. Ernst CB. Fasciotomy: an appraisal of controversial issues. Arch Surg. 1981;116:1480.

    Google Scholar 

  79. Sheridan GW, Matsen III FA. Fasciotomy in the treatment of the acute compartment syndrome. J Bone Joint Surg Am. 1976;58:112–5.

    PubMed  CAS  Google Scholar 

  80. Fitzgerald AM, Gaston P, Wilson Y, Quaba A, McQueen MM. Long-term sequelae of fasciotomy wounds. Br J Plast Surg. 2000;53:690–3.

    Article  PubMed  CAS  Google Scholar 

  81. Rorabeck CH. The treatment of compartment syndromes of the leg. J Bone Joint Surg. 1984;66B:93–7.

    Google Scholar 

  82. Gould MT, Langworthy MJ, Santore R, Provencher MT. An analysis of orthopaedic liability in the acute care setting. Clin Orthop. 2003;407:59–66.

    Article  PubMed  Google Scholar 

  83. Templeman D, Schmidt RD, Varecka TF. The economic cost of missed compartment syndromes. Orthop Trans. 1993;17:989.

    Google Scholar 

  84. Bhattacharyya T, Vrahas MS. The medical-legal aspects of compartment syndrome. J Bone Joint Surg Am. 2004;86:864–8.

    PubMed  Google Scholar 

  85. Shadgan B, Menon M, Sanders D, Berry G, Martin Jr C, Duffy P, et al. Current thinking about acute compartment syndrome of the lower extremity. Can J Surg. 2010;53:329–34.

    PubMed  Google Scholar 

  86. Committee on Professional Liability. Managing orthopaedic malpractice risk. 2nd ed. Rosemont: American Academy of Orthopaedic Surgeons; 2000.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David A. Forsh MD .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media New York

About this chapter

Cite this chapter

Forsh, D.A., Wolinsky, P.R. (2014). Compartment Syndrome. In: Smith, W., Stahel, P. (eds) Management of Musculoskeletal Injuries in the Trauma Patient. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8551-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-8551-3_10

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8550-6

  • Online ISBN: 978-1-4614-8551-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics