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Tissue Engineering: Growing Replacement Human Tissue in the Lab

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Abstract

In the last few chapters, we have discussed the state-of-the-art treatments for resolving missing or diseased tissues and organs. For the most part, synthetic or processed natural materials are used to design implants, etc. None of the treatments resemble or approach the sophistication of the body’s own original tissue. Over the past two decades or so, scientists and engineers have begun to create tissues and organs in the laboratory, with the aim of eventually using those constructs for treatment of disease. Although simple tissues like skin substitutes are already available, more complex tissues and organs are still under development. Nevertheless, this field of tissue engineering or regenerative medicine holds the promise of someday being capable of producing body parts which will be fully integrated into the patient’s body and alleviate the shortage of transplantable organs.

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References

  1. Langer, R., & Vacanti, J. (1993). Tissue engineering. Science, 280, 920–926.

    Article  Google Scholar 

  2. Center for Disease Control and Prevention. (2013). Leading causes of death. http://www.cdc.gov/nchs/fastats/lcod.htm.

  3. Badylak, S., Taylor, D., & Uygun, K. (2011). Whole-organ tissue engineering: Decellularization and recellularization of three-dimensional matrix scaffolds. Annual Review of Biomedical Engineering, 13, 27–53.

    Article  Google Scholar 

  4. Committee on the Biological and Biomedical Applications of Stem Cells. (2002). Stem cells and the future of regenerative medicine. Washington, DC: National Academy Press.

    Google Scholar 

  5. Wilson, J., & Chaikof, E. (2008). Challenges and emerging technologies in the immunoisolation of cells and tissues. Advanced Drug Delivery Reviews, 14, 124–145.

    Article  Google Scholar 

  6. Ikada, Y. (2006). Challenges in tissue engineering. Journal of the Royal Society, Interface, 3, 589–601.

    Article  Google Scholar 

  7. Kaully, T., Kaufman-Francis, K., Lesman, A. & Levenberg, S. et al. (2010). Vascularization: The conduit to viable engineered tissues. In P. Johnson & A. Mikos (Eds.), Advances in tissue engineering: Angiogenesis. New Rochelle, NY: Mary Ann Liebert.

    Google Scholar 

  8. Mikos, A., Bao, Y., Cima, L., Ingber, D., Vacanti, J. & Langer, R. et al. (1993). Preparation of poly(glycolic acid) bonded fiber structures for cell attachment and transplantation. Journal of Biomedical Materials Research, 27, 183–189. http://www.cdc.gov/nchs/fastats/lcod.htm.

    Google Scholar 

  9. Lee, K., Silva, E., & Mooney, D. (2011). Growth factor delivery-based tissue engineering: General approaches and a review of recent developments. Journal of the Royal Society, Interface, 8, 153–170.

    Article  Google Scholar 

  10. Korossis, S., Bolland, F., Kearney, J., Fisher, J. & Ingham, E. et al. (2005). Bioreactors in tissue engineering. In N. Ashammakhi & R. Reis (Eds.), Topics in tissue engineering (Vol. 2). EXPERTISSUES e-book.

    Google Scholar 

  11. Benders, K., van Weeren, P., Badylak, S., Saris, D., Dhert, W. & Malda, J. et al. (2013). Extracellular matrix scaffolds for cartilage and bone regeneration. Trends in Biotechnology, 31, 169–176.

    Article  Google Scholar 

  12. Ikeda, E., Morita, R., Nakao, K., Ishida, K., Nakamura, T. & Takano-Yamamoto, T. et al. (2009). Fully functional bioengineered tooth replacement as an organ replacement therapy. Proceedings of the National Academy of Sciences, 106, 13145–13146.

    Article  Google Scholar 

  13. Gaida, J., Alfredson, H., Kiss, Z., Bass, S. & Cook, J. et al. (2010). Asymptomatic Achilles tendon pathology is associated with a central fat distribution in men and a peripheral fat distribution in women: A cross-sectional study of 298 individuals. BMC Musculoskeletal Disorders, 11, 41.

    Article  Google Scholar 

  14. Derwin, K., Baker, E., Spragg, R., Leigh, D. & Iannotti, J. et al. (2006). Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties. Journal of Bone and Joint Surgery. American volume, 88, 2665–2672.

    Article  Google Scholar 

  15. Fountain, H. (2012, September 15). A first: Organs tailor-made with body’s own cells. The New York Times, New York.

    Google Scholar 

  16. Menasche, P., Hagege, A., Vilquin, J-T., Desnos, M., Abergel, E. & Pouzet, B. et al. (2003). Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction. Journal of the American College of Cardiology, 41, 1078–1083.

    Article  Google Scholar 

  17. Vunjak-Novakovic, G., Lui, K., Tandon, N. & Chien, K. et al. (2011). Bioengineering heart muscle: A paradigm for regenerative medicine. Annual Review of Biomedical Engineering, 13, 245–267.

    Article  Google Scholar 

  18. Jha, A. (2013, January 29). Cell researchers take new route to heart repair. The Guardian, London.

    Google Scholar 

  19. Vesely, I. (2005). Heart valve tissue engineering. Circulation Research, 97, 743–755.

    Article  Google Scholar 

  20. Basu, J., Genheimer, C., Rivera, E., Payne, R., Mihalko, K. & Guthrie, K., et al. (2011). Functional evaluation of primary cell/biomaterial neo-kidney augment prototypes for renal tissue engineering. Cell Transplantation, 20, 1771–1790.

    Article  Google Scholar 

  21. Xinaris, C., Benedetti, V., Rizzo, P., Abbate, M., Corna, D. & Azzollini, N. et al. (2012). In vivo maturation of functional renal organoids formed from embryonic cell suspensions. Journal of the American Society of Nephrology, 23, 1857–1868.

    Article  Google Scholar 

  22. Atala, A. (2011). Tissue engineering of human bladder. British Medical Bulletin, 97, 81–104.

    Article  Google Scholar 

  23. Khan, A., Shaik, M., Parveen, N., Rajendraprasad, A., Aleem, M. & Habeeb, M. et al. (2010). Human fetal-derived stem cell transplantation as supportive modality in the management of end-stage decompensated liver cirrhosis. Cell Transplantation, 19, 409–418.

    Google Scholar 

  24. Dalton, P., Harvey, A., Oudega, M. & Plant, G. et al. (2008). Tissue engineering of the nervous system. In C. Van Blitterswijk et al. (Eds.), Tissue engineering (pp. 611–647). New York, NY: Academic.

    Chapter  Google Scholar 

  25. MedMarket Dilligence LLC. (2010). Tissue engineering, cell therapy and transplantation: products, technologies, and market opportunities, worldwide, 2009–2018. http://www.mediligence.com/rpt/rpt-s520.htm.

  26. Hellman, K. (2008). Tissue engineering: Translating science to product. In N. Ashammakhi, R. Reis, & F. Chiellini, (Eds.), Topics in tissue engineering. http://www.oulu.fi/spareparts/ebook_topics_in_t_e_vol4/index.html

  27. Mansbridge, J. (2006). Commercial considerations in tissue engineering. Journal of Anatomy, 209, 527–532.

    Article  Google Scholar 

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Baran, G.R., Kiani, M.F., Samuel, S.P. (2014). Tissue Engineering: Growing Replacement Human Tissue in the Lab. In: Healthcare and Biomedical Technology in the 21st Century. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8541-4_11

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  • DOI: https://doi.org/10.1007/978-1-4614-8541-4_11

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  • Publisher Name: Springer, New York, NY

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  • Online ISBN: 978-1-4614-8541-4

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