Hereditary Colorectal Cancer

  • James ChurchEmail author


  • Colorectal cancer is both a genetic and epigenetic disease.

  • The classes of genes primarily involved are largely those concerned with regulation of cell growth, tumor suppressor genes and proto-oncogenes, and the average sporadic colorectal cancer has accumulated 90 different mutations.

  • Most mutations occur because of the environment and about one third of colorectal cancers have a hereditary component.

  • Hereditary colorectal cancer is important because members of affected families can be identified as high risk and be advised to have early, intensive surveillance or even prophylactic surgery.

  • Hereditary colorectal cancer can be broadly divided into non-syndromic and syndromic conditions.


Familial Adenomatous Polyposis Lynch Syndrome Serrate Polyp Juvenile Polyposis Amsterdam Criterion 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of Colorectal SurgeryDigestive Diseases Institute, Cleveland Clinic FoundationClevelandUSA

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