IBD: Medical Management

  • Bruce E. SandsEmail author


  • The cause of inflammatory bowel disease (IBD) is unknown, but it is believed to be an uncontrolled immune response within the intestinal mucosa leading to inflammation in genetically predisposed individuals.

  • Multifactorial evidence suggests a defect of innate immune response to microbial agents and abnormalities in adaptive immunity and epithelial barrier function.

  • The goals of therapy include controlling symptoms, improving quality of life, and minimizing short-term and long-term complications of disease and treatment.

  • There are two phases of treatment: (1) inducing remission in active disease and (2) maintaining remission.

  • Surgery is usually reserved for treating medically refractory disease or for specific complications.


Short Bowel Syndrome Pyoderma Gangrenosum Certolizumab Pegol Perianal Fistula Toxic Megacolon 
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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of GastroenterologyMGH Crohn’s and Colits Center, Massachusetts General HospitalBostonUSA
  2. 2.Department of MedicineHarvard School of MedicineBostonUSA

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