Abstract
The development of bioavailable solid dispersions requires the use of secondary materials for stabilizing the amorphous dispersion while also enhancing dissolution and solubility of the new chemical entity. With the increased use of amorphous dispersions, hypromellose acetate succinate (HPMCAS) has emerged as a commonly used excipient for formulation design. This unique material, originally designed to enhance thermoplastic properties of cellulosics, can be used to enhance the solubility of many poorly soluble amorphous products. This chapter details the properties of HPMCAS that make it a beneficial material for use in solid dispersion formulation, with a specific focus on relevant properties for melt extrusion.
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References
Cerea M, Foppoli A et al (2008) Dry coating of soft gelatin capsules with HPMCAS. Drug Dev Ind Pharm 34:1196–1200
Curatolo W, Nightingale JA et al (2009) Utility of hydroxypropylmethylcellulose acetate succinate (HPMCAS) for initiation and maintenance of drug supersaturation in the GI milieu. Pharm Res 26:1419–1431
Kablitz CD, Harder K et al (2006) Dry coating in a rotary fluid bed. Eur J Pharm Sci 27:212–219
Klar F, Urbanez NA (2009) The role of capillary force promoters in dry coating procedures—evaluation of acetylated monoglyceride, isopropyl myristate and palmitate. Eur J Pharm Biopharm 71:124–129
Miyajima M, Yamaguchi Y et al (1991) Pharmaceutical composition of dihydropyridine compound. US Patent 4983593
Nagai T, Sekigawa F, Hoshi N (1998) Application of HPMC and HPMCAS to aqueous film coating of pharmaceutical dosage forms. In: McGinity JW (ed) Aqueous polymeric coatings for pharmaceutical dosage forms. Marcel Dekker, New York
Obara S, Maruyama N et al (1999) Dry coating—an innovative enteric coating method using a cellulose derivative. Eur J Pharm Biopharm 47:51–59
Onda Y, Muto H et al (1980) Ether-ester derivatives of cellulose and their applications. US Patent 4226981
Shin-Etsu Chemical Co., Ltd. (2010) Shin-Etsu AQOAT product brochure
Tamabuchi T, Nishimura M et al (1993) Improving the pharmaceutical properties of 4″-O-(4-Methoxyphenyl) acetyltylosin by preparing solid dispersions with carboxymethyl ethyl cellulose. Yakuzaigaku 53:221–228
Tanno F, Nishiyama Y et al (2004) Evaluation of hypromellose acetate succinate (HPMCAS) as a carrier in solid dispersions. Drug Dev Ind Pharm 30:9–17
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© 2013 American Association of Pharmaceutical Scientists
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Obara, S., Tanno, F., Sarode, A. (2013). Properties and Applications of Hypromellose Acetate Succinate (HPMCAS) for Solubility Enhancement Using Melt Extrusion. In: Repka, M., Langley, N., DiNunzio, J. (eds) Melt Extrusion. AAPS Advances in the Pharmaceutical Sciences Series, vol 9. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8432-5_4
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DOI: https://doi.org/10.1007/978-1-4614-8432-5_4
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