CNS Germ Cell Tumors

  • César R. Lacruz
  • Javier Sáenz de Santamaría
  • Ricardo H. Bardales
Part of the Essentials in Cytopathology book series (EICP, volume 13)


CNS germ cell tumors are similar to their more common extra-neuraxial counterparts, sharing genomic alterations and immunostaining properties.


Germ Cell Tumor Embryonal Carcinoma Mature Teratoma Immature Teratoma Cytologic Picture 
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Suggested Reading

  1. Akhtar M, Ali A, Huq M, Bakry M. Fine-needle aspiration biopsy of seminoma and dysgerminoma cytologic, histologic, and electron microscopic correlations. Diagn Cytopathol. 1990a;6:99–105.PubMedCrossRefGoogle Scholar
  2. Akhtar M, Ali MA, Sackey K, Jackson D, Bakry M. Fine-needle aspiration biopsy diagnosis of endodermal sinus tumor: histologic and ultrastructural correlations. Diagn Cytopathol. 1990b;6:184–92.PubMedCrossRefGoogle Scholar
  3. Balslev E, Francis D, Jacobsen GK. Testicular germ cell tumors. Classification based on fine needle aspiration biopsy. Acta Cytol. 1990;34:690–4.PubMedGoogle Scholar
  4. Crawford JR, Santi MR, Vezina G, Myseros JS, Keating RF, LaFond DA, Rood BR, MacDonald TJ, Packer RJ. CNS germ cell tumor (CNSGCT) of childhood: presentation and delayed diagnosis. Neurology. 2007;68:1668–73.PubMedCrossRefGoogle Scholar
  5. Gaoyu C, Deyu G, Zhi C, Hua E. Yolk sac tumor in the fourth ventricle: a case report. Clin Neurol Neurosurg. 2009;111:636–7.PubMedCrossRefGoogle Scholar
  6. Geramizadeh B, Daneshbood Y, Karimi M. Cytology of brain metastasis of yolk sac tumor. Acta Cytol. 2005;49:110–1.PubMedCrossRefGoogle Scholar
  7. Kraichoke S, Cosgrove M, Chandrasoma P. Granulomatous inflammation in pineal germinoma. A cause of diagnostic failure at stereotaxic brain biopsy. Am J Surg Pathol. 1988;12:655–60.PubMedCrossRefGoogle Scholar
  8. Ng HK. Cytologic diagnosis of intracranial germinomas in smear preparations. Acta Cytol. 1995;39:696–7.Google Scholar
  9. Salzman KL, Rojiani AM, Buatti J, Quisling RG, Marcus Jr RB, Maria BL, Mickle JP, Kedar A. Primary intracranial germ cell tumors: clinicopathologic review of 32 cases. Pediatr Pathol Lab Med. 1997;17:713–27.PubMedCrossRefGoogle Scholar
  10. Sawamura Y, Ikeda J, Shirato H, Tada M, Abe H. Germ cell tumors of the central nervous system: treatment consideration based on 111 cases and their long-term clinical outcomes. Eur J Cancer. 1998;34:104–10.PubMedCrossRefGoogle Scholar
  11. Schneider DT, Zahn S, Sievers S, Alemazkour K, Reifenberger G, Wiestler OD, Calaminus G, Göbel U, Perlman EJ. Molecular genetic analysis of central nervous system germ cell tumors with comparative genomic hybridization. Mod Pathol. 2006;19:864–73.PubMedGoogle Scholar
  12. Zaharopoulos P, Wong JY. Cytology of common primary midline brain tumors. Acta Cytol. 1980;24:384–90.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • César R. Lacruz
    • 1
  • Javier Sáenz de Santamaría
    • 2
  • Ricardo H. Bardales
    • 3
  1. 1.University General Hospital Gregorio MarañónMadridSpain
  2. 2.University Hospital Extremadura Medical SchoolBadajozSpain
  3. 3.Outpatient Pathology AssociatesSacramentoUSA

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