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Pineal Tumors: Viewpoint—Fractionated Radiation Therapy

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Principles and Practice of Stereotactic Radiosurgery

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Abstract

Radiotherapy plays a vital role in the vast majority of tumors that arise from the pineal region. While most pineal tumors are quite rare, refinement of radiation techniques and doses over the past several decades, along with concomitant improvements in surgical techniques and chemotherapeutic regimens, have led to improvements in patient outcomes.

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References

  1. Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29 [Comparative Study].

    Article  PubMed  Google Scholar 

  2. Zulch K. [Some characteristics of brain tumors related to the age, site and sex of the tumor patients]. Zentralbl Chir. 1965;90(23): 890–8.

    CAS  PubMed  Google Scholar 

  3. Al-Hussaini M, Sultan I, Abuirmileh N, Jaradat I, Qaddoumi I. Pineal gland tumors: experience from the SEER database. J Neurooncol. 2009;94(3):351–8 [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov’t].

    Article  PubMed Central  PubMed  Google Scholar 

  4. Burger PC, Scheithauer BW. Pineal tumors. In: Tumors of the central nervous system: atlas of tumor pathology. Bethesda: Armed Forces Institute of Pathology; 1994. p. 227–37.

    Google Scholar 

  5. Haddock MG, Schild SE, Scheithauer BW, Schomberg PJ. Radiation therapy for histologically confirmed primary central nervous system germinoma. Int J Radiat Oncol Biol Phys. 1997;38(5):915–23.

    Article  CAS  PubMed  Google Scholar 

  6. Mena H, Nakazato Y, Jouvet A, Scheithauer BW. Pineal parenchymal tumors. In: Kleihues P, Cavanee WK, editors. World Health Organization classification of tumours. Pathology and genetics. Tumors of the nervous system. Lyon: IARC Press; 2000. p. 115–21.

    Google Scholar 

  7. Schild SE, Haddock MG, Scheithauer BW, Marks LB, Norman MG, Burger PC, et al. Nongerminomatous germ cell tumors of the brain. Int J Radiat Oncol Biol Phys. 1996;36(3):557–63.

    Article  CAS  PubMed  Google Scholar 

  8. Schild SE, Scheithauer BW, Haddock MG, Wong WW, Lyons MK, Marks LB, et al. Histologically confirmed pineal tumors and other germ cell tumors of the brain. Cancer. 1996;78(12):2564–71.

    Article  CAS  PubMed  Google Scholar 

  9. Schild SE, Scheithauer BW, Schomberg PJ, Hook CC, Kelly PJ, Frick L, et al. Pineal parenchymal tumors. Clinical, pathologic, and therapeutic aspects. Cancer. 1993;72(3):870–80 [Review].

    Article  CAS  PubMed  Google Scholar 

  10. Abay 2nd EO, Laws Jr ER, Grado GL, Bruckman JE, Forbes GS, Gomez MR, et al. Pineal tumors in children and adolescents. Treatment by CSF shunting and radiotherapy. J Neurosurg. 1981;55(6):889–95 [Comparative Study].

    Article  PubMed  Google Scholar 

  11. Donat JF, Okazaki H, Gomez MR, Reagan TJ, Baker Jr HL, Laws Jr ER. Pineal tumors. A 53-year experience. Arch Neurol. 1978;35(11):736–40.

    Article  CAS  PubMed  Google Scholar 

  12. Marsh WR, Laws Jr ER. Shunting and irradiation of pineal tumors. Clin Neurosurg. 1985;32:384–96 [Review].

    CAS  PubMed  Google Scholar 

  13. Fain JS, Tomlinson FH, Scheithauer BW, Parisi JE, Fletcher GP, Kelly PJ, et al. Symptomatic glial cysts of the pineal gland. J Neurosurg. 1994;80(3):454–60.

    Article  CAS  PubMed  Google Scholar 

  14. Fleege MA, Miller GM, Fletcher GP, Fain JS, Scheithauer BW. Benign glial cysts of the pineal gland: unusual imaging characteristics with histologic correlation. AJNR Am J Neuroradiol. 1994;15(1):161–6.

    CAS  PubMed  Google Scholar 

  15. Popovic EA, Kelly PJ. Stereotactic procedures for lesions of the pineal region. Mayo Clin Proc. 1993;68(10):965–70 [Case Reports Review].

    Article  CAS  PubMed  Google Scholar 

  16. Linstadt D, Wara WM, Edwards MS, Hudgins RJ, Sheline GE. Radiotherapy of primary intracranial germinomas: the case against routine craniospinal irradiation. Int J Radiat Oncol Biol Phys. 1988;15(2):291–7 [Research Support, Non-U.S. Gov’t].

    Article  CAS  PubMed  Google Scholar 

  17. Rich TA, Cassady JR, Strand RD, Winston KR. Radiation therapy for pineal and suprasellar germ cell tumors. Cancer. 1985;55(5):932–40.

    Article  CAS  PubMed  Google Scholar 

  18. Wara WM, Jenkin RD, Evans A, Ertel I, Hittle R, Ortega J, et al. Tumors of the pineal and suprasellar region: Childrens Cancer Study Group treatment results 1960–1975: a report from Childrens Cancer Study Group. Cancer. 1979;43(2):698–701 [Research Support, U.S. Gov’t, P.H.S.].

    Article  CAS  PubMed  Google Scholar 

  19. Bjornsson J, Scheithauer BW, Okazaki H, Leech RW. Intracranial germ cell tumors: pathobiological and immunohistochemical aspects of 70 cases. J Neuropathol Exp Neurol. 1985;44(1):32–46.

    Article  CAS  PubMed  Google Scholar 

  20. Bruce J, Fetell M, Stein B. Incidence of spinal metastases in patients with malignant pineal region tumors: avoidance of prophylactic cranial irradiation (meeting abstract). J Neurosurg. 1990;72:354A.

    Google Scholar 

  21. Bruce J, Stein B, Balmaceda C. Management of pineal region germ cell tumors: results and long-term follow-up (meeting abstract). Proc Ann Meet Am Soc Clin Oncol. 1994;13:A505.

    Google Scholar 

  22. Dearnaley DP, A’Hern RP, Whittaker S, Bloom HJ. Pineal and CNS germ cell tumors: Royal Marsden Hospital experience 1962–1987. Int J Radiat Oncol Biol Phys. 1990;18(4):773–81.

    Article  CAS  PubMed  Google Scholar 

  23. Fuller BG, Kapp DS, Cox R. Radiation therapy of pineal region tumors: 25 new cases and a review of 208 previously reported cases. Int J Radiat Oncol Biol Phys. 1994;28(1):229–45.

    Article  CAS  PubMed  Google Scholar 

  24. Hoffman HJ, Otsubo H, Hendrick EB, Humphreys RP, Drake JM, Becker LE, et al. Intracranial germ-cell tumors in children. J Neurosurg. 1991;74(4):545–51.

    Article  CAS  PubMed  Google Scholar 

  25. Jennings MT, Gelman R, Hochberg F. Intracranial germ-cell tumors: natural history and pathogenesis. J Neurosurg. 1985;63(2): 155–67 [Review].

    Article  CAS  PubMed  Google Scholar 

  26. Linggood RM, Chapman PH. Pineal tumors. J Neurooncol. 1992;12(1):85–91.

    CAS  PubMed  Google Scholar 

  27. Mineura K, Sasajima T, Sakamoto T, Kowada M. Gan No Rinsho. 1990;36(14):2399–403 [Results of the treatment of intracranial germ cell tumors].

    CAS  PubMed  Google Scholar 

  28. Sano K. Pineal region tumors: problems in pathology and treatment. Clin Neurosurg. 1983;30:59–91.

    CAS  PubMed  Google Scholar 

  29. Sano K, Matsutani M, Seto T. So-called intracranial germ cell tumours: personal experiences and a theory of their pathogenesis. Neurol Res. 1989;11(2):118–26 [Review].

    CAS  PubMed  Google Scholar 

  30. Takakura K. Intracranial germ cell tumors. Clin Neurosurg. 1985;32:429–44 [Case Reports Comparative Study Research Support, Non-U.S. Gov’t Review].

    CAS  PubMed  Google Scholar 

  31. Wolden SL, Wara WM, Larson DA, Prados MD, Edwards MS, Sneed PK. Radiation therapy for primary intracranial germ-cell tumors. Int J Radiat Oncol Biol Phys. 1995;32(4):943–9.

    Article  CAS  PubMed  Google Scholar 

  32. Yoshida J, Sugita K, Kobayashi T, Takakura K, Shitara N, Matsutani M, et al. Prognosis of intracranial germ cell tumours: effectiveness of chemotherapy with cisplatin and etoposide (CDDP and VP-16). Acta Neurochir (Wien). 1993;120(3–4):111–7.

    Article  CAS  Google Scholar 

  33. Gobel U, Bamberg M, Engert J, Gnekow AK, Haas HJ, Jurgens H, et al. [Treatment of non-testicular germ cell tumors in children and adolescents with BEP and VIP: initial results of the MAKEI 89 therapy study]. Klin Padiatr. 1991;203(4):236–45 [Clinical Trial Multicenter Study].

    Article  CAS  PubMed  Google Scholar 

  34. Hasegawa T, Kondziolka D, Hadjipanayis CG, Flickinger JC, Lunsford LD. The role of radiosurgery for the treatment of pineal parenchymal tumors. Neurosurgery. 2002;51(4):880–9.

    PubMed  Google Scholar 

  35. Hasegawa T, Kondziolka D, Hadjipanayis CG, Flickinger JC, Lunsford LD. Stereotactic radiosurgery for CNS nongerminomatous germ cell tumors. Report of four cases. Pediatr Neurosurg. 2003;38(6):329–33 [Case Reports].

    Article  PubMed  Google Scholar 

  36. Herrmann HD, Westphal M, Winkler K, Laas RW, Schulte FJ. Treatment of nongerminomatous germ-cell tumors of the pineal region. Neurosurgery. 1994;34(3):524–9. discussion 9.

    Article  CAS  PubMed  Google Scholar 

  37. Bamberg M, Kortmann RD, Calaminus G, Becker G, Meisner C, Harms D, et al. Radiation therapy for intracranial germinoma: results of the German cooperative prospective trials MAKEI 83/86/89. J Clin Oncol. 1999;17(8):2585–92 [Clinical Trial Multicenter Study].

    CAS  PubMed  Google Scholar 

  38. O’Neil S, Ji L, Buranahirun C, Azoff J, Dhall G, Khatua S, et al. Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. Pediatr Blood Cancer. 2011;57(4):669–73.

    Article  PubMed  Google Scholar 

  39. Tseng CK, Tsang NM, Jaing TH, Liau CT, Wu CT, Lin KL. Outcome of central nervous system germinoma treatment by chemoradiation. J Pediatr Hematol Oncol. 2011;33(4):e138–42 [Clinical Trial].

    Article  CAS  PubMed  Google Scholar 

  40. Dattoli MJ, Newall J. Radiation therapy for intracranial germinoma: the case for limited volume treatment. Int J Radiat Oncol Biol Phys. 1990;19(2):429–33.

    Article  CAS  PubMed  Google Scholar 

  41. Aoyama H, Shirato H, Kakuto Y, Inakoshi H, Nishio M, Yoshida H, et al. Pathologically-proven intracranial germinoma treated with radiation therapy. Radiother Oncol. 1998;47(2):201–5 [Multicenter Study].

    Article  CAS  PubMed  Google Scholar 

  42. Shikama N, Ogawa K, Tanaka S, Toita T, Nakamura K, Uno T, et al. Lack of benefit of spinal irradiation in the primary treatment of intracranial germinoma: a multiinstitutional, retrospective review of 180 patients. Cancer. 2005;104(1):126–34 [Evaluation Studies Multicenter Study Research Support, Non-U.S. Gov’t].

    Article  PubMed  Google Scholar 

  43. Yen SH, Chen YW, Huang PI, Wong TT, Ho DM, Chang KP, et al. Optimal treatment for intracranial germinoma: can we lower radiation dose without chemotherapy? Int J Radiat Oncol Biol Phys. 2010;77(4):980–7 [Evaluation Studies Research Support, Non-U.S. Gov’t].

    Article  PubMed  Google Scholar 

  44. Shirato H, Nishio M, Sawamura Y, Myohjin M, Kitahara T, Nishioka T, et al. Analysis of long-term treatment of intracranial germinoma. Int J Radiat Oncol Biol Phys. 1997;37(3):511–5 [Research Support, Non-U.S. Gov’t].

    Article  CAS  PubMed  Google Scholar 

  45. Kellie SJ, Boyce H, Dunkel IJ, Diez B, Rosenblum M, Brualdi L, et al. Intensive cisplatin and cyclophosphamide-based chemotherapy without radiotherapy for intracranial germinomas: failure of a primary chemotherapy approach. Pediatr Blood Cancer. 2004;43(2): 126–33 [Clinical Trial].

    Article  PubMed  Google Scholar 

  46. Balmaceda C, Heller G, Rosenblum M, Diez B, Villablanca JG, Kellie S, et al. Chemotherapy without irradiation—a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. J Clin Oncol. 1996;14(11):2908–15 [Clinical Trial Controlled Clinical Trial Multicenter Study Research Support, Non-U.S. Gov’t].

    CAS  PubMed  Google Scholar 

  47. da Silva NS, Cappellano AM, Diez B, Cavalheiro S, Gardner S, Wisoff J, et al. Primary chemotherapy for intracranial germ cell tumors: results of the third international CNS germ cell tumor study. Pediatr Blood Cancer. 2010;54(3):377–83 [Clinical Trial].

    Article  PubMed  Google Scholar 

  48. Calaminus G, Frappaz D, Kortmann RD, et al. Localized and metastatic nongerminoma treated according to the SIOP CNS GCT 96 protocol: update on risk profiles and outcome. J Neurooncol. 2008;10:418.

    Google Scholar 

  49. Ogawa K, Toita T, Nakamura K, Uno T, Onishi H, Itami J, et al. Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors: a multiinstitutional retrospective analysis of 41 patients. Cancer. 2003;98(2):369–76.

    Article  PubMed  Google Scholar 

  50. Matsutani M. Treatment of intracranial germ cell tumors: the second phase II study of Japanese GCT Study Group. J Neurooncol. 2008;10:420.

    Google Scholar 

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Authors and Affiliations

  1. Department of Radiation Oncology, Mayo Clinic College of Medicine, Mayo Clinic Arizone, 5777 East Mayo Boulevard, Phoenix, AZ, 85054, USA

    William G. Rule M.D. & Steven E. Schild

Authors
  1. William G. Rule M.D.
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  2. Steven E. Schild
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Correspondence to William G. Rule M.D. .

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Editors and Affiliations

  1. Department of Neurosurgery, SUNY Upstate Medical University, Syracuse, USA

    Lawrence S. Chin

  2. Dept. of Radiation Oncology, Univ. of Maryland School of Medicine, Baltimore, Maryland, USA

    William F. Regine

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Rule, W.G., Schild, S.E. (2015). Pineal Tumors: Viewpoint—Fractionated Radiation Therapy. In: Chin, L., Regine, W. (eds) Principles and Practice of Stereotactic Radiosurgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8363-2_36

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  • DOI: https://doi.org/10.1007/978-1-4614-8363-2_36

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-8362-5

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