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Gram-Negative Folliculitis

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Acneiform Eruptions in Dermatology

Abstract

Gram-negative folliculitis is a complication of treatment of acne or rosaceas with long-term oral antibiotics, usually tetracyclines. It is caused by the replacement of the gram-positive flora of the mucous membranes of the nose with gram-negative bacteria, which is spread to the face. Common causative organisms include Escherichia coli, Pseudomonas aeruginosa, Serratia marcescens, Klebsiella, and Proteus mirabilis. Gram-negative folliculitis should be considered in acne patients who have a flare-up of pustular or cystic lesions while on antibiotics and in patients who have no significant improvement of acne lesions after 3–6 months of antibiotic therapy.

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References

  1. Fulton Jr JE, McGinley K, Leyden J, Marples R. Gram-negative folliculitis in acne vulgaris. Arch Dermatol. 1968;98:349–53.

    Article  PubMed  Google Scholar 

  2. Neubert U, Jansen T, Plewig G. Bacteriologic and immunologic aspects of gram-negative folliculitis: a study of 46 patients. Int J Dermatol. 1999;38:270–4.

    Article  PubMed  CAS  Google Scholar 

  3. Esterly NB, Koransky JS, Furey NL, Trevisan M. Neutrophil chemotaxis in patients with acne receiving oral tetracycline therapy. Arch Dermatol. 1984;120:1308–13.

    Article  PubMed  CAS  Google Scholar 

  4. Bottone EJ, Perez 2nd AA, Oeser JL. Loofah sponges as reservoirs and vehicles in the transmission of potentially pathogenic bacterial species to human skin. J Clin Microbiol. 1994;32:469–72.

    PubMed  CAS  Google Scholar 

  5. Leyden JJ, Marples RR, Mills Jr OH, Kligman AM. Gram-negative folliculitis—a complication of antibiotic therapy in acne vulgaris. Br J Dermatol. 1973;88:533–8.

    Article  PubMed  CAS  Google Scholar 

  6. Chastain MA. A cycle: recurrent gram-negative folliculitis with Citrobacter diversus (koseri) following eradication of recurrent staphylococcal pyoderma. Arch Dermatol. 2000;136:803.

    Article  PubMed  CAS  Google Scholar 

  7. Mostafa WZ. Citrobacter freundii in gram-negative folliculitis. J Am Acad Dermatol. 1989; 20:504–5.

    Article  PubMed  CAS  Google Scholar 

  8. Bartholow P, Maibach HI. Gram-negative folliculitis without systemic antibiotics? Arch Dermatol. 1979;115:676.

    Article  PubMed  CAS  Google Scholar 

  9. Boni R, Nehrhoff B. Treatment of gram-negative folliculitis in patients with acne. Am J Clin Dermatol. 2003;4:273–6.

    Article  PubMed  Google Scholar 

  10. James WD, Leyden JJ. Treatment of gram-negative folliculitis with isotretinoin: positive clinical and microbiologic response. J Am Acad Dermatol. 1985;12:319–24.

    Article  PubMed  CAS  Google Scholar 

  11. Plewig G, Nikolowski J, Wolff HH. Action of isotretinoin in acne rosacea and gram-negative folliculitis. J Am Acad Dermatol. 1982;6:766–85.

    Article  PubMed  CAS  Google Scholar 

  12. Landthaler M, Kummermehr J, Wagner A, Plewig G. Inhibitory effects of 13-cis-retinoic acid on human sebaceous glands. Arch Dermatol Res. 1980;269:297–309.

    Article  PubMed  CAS  Google Scholar 

  13. Neubert U, Plewig G, Ruhfus A. Treatment of gram-negative folliculitis with isotretinoin. Arch Dermatol Res. 1986;278:307–13.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Ani L. Tajirian M.D. .

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Tajirian, A.L., Kircik, L.H. (2014). Gram-Negative Folliculitis. In: Zeichner, J. (eds) Acneiform Eruptions in Dermatology. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8344-1_7

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  • DOI: https://doi.org/10.1007/978-1-4614-8344-1_7

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