Advertisement

Steatocystoma Multiplex

  • Alejandra Vivas
  • Jonette Keri
Chapter

Abstract

Steatocystoma multiplex (SM) is one of the infrequent forms of keratin disorders characterized by multiple benign sebaceous gland papules and/or nodules, usually located in hair-covered areas where pilosebaceous glands are well developed; however this condition may occur anywhere on the body. Though it is mostly thought to be a hereditary autosomal dominant disease associated to missense mutations of the keratin 17 (K17) gene, many sporadic cases have been reported. This suggests the disease may have a multifactorial etiology. Steatocystoma simplex is the sporadic solitary tumor counterpart to SM and has no hereditary tendency. Diagnosis is mainly clinical, but histopathology is characteristic and aids to confirmation of diagnosis when uncertain. Some of the frequent locations of SM include neck, chest, upper back, proximal extremities, and face, which are also common areas for acne to present. Due to the many similarities of these two conditions, SM should be included in the differential diagnosis when evaluating an acneiform eruption.

Keywords

Sebaceous Gland Lichen Planus Dermoid Cyst Hidradenitis Suppurativa Proximal Extremity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Oh SW, Kim MY, Lee JS, Kim SC. Keratin 17 mutation in pachyonychia congenita type 2 patient with early onset steatocystoma multiplex and Hutchinson-like tooth deformity. J Dermatol. 2006;33:161–4.PubMedCrossRefGoogle Scholar
  2. 2.
    Wang JF, Lu WS, Sun LD, et al. Novel missense mutation of keratin in Chinese family with steatocystoma multiplex. Eur Acad Dermatol Venereol. 2009;23:723–4.CrossRefGoogle Scholar
  3. 3.
    Kanda M, Natsuga K, Nishie W, et al. Morphological and genetic analysis of steatocystoma multiplex in an Asian family with pachyonychia congenita type 2 harbouring a KRT17 missense mutation. Br J Dermatol. 2009;160:465–8.PubMedCrossRefGoogle Scholar
  4. 4.
    Hurlimann AF, Panizzon RG, Burg G. Eruptive vellus hair cyst and steatocystoma multiplex: hybrid cysts. Dermatology. 1996;192:64–6.PubMedCrossRefGoogle Scholar
  5. 5.
    Moritz DL, Silverman RA. Steatocystoma multiplex treated with isotretinoin: a delayed response. Cutis. 1988;42:437–9.PubMedGoogle Scholar
  6. 6.
    Ahn SK, Chung J, Lee WS, Lee SH, Choi EH. Hybrid cysts showing alternate combination of eruptive vellus hair cyst, steatocystoma multiplex, and epidermoid cyst, and an association among the three conditions. Am J Dermatopathol. 1996;18:645–9.PubMedCrossRefGoogle Scholar
  7. 7.
    Yoshida M, Oiso N, Kurokawa I, Tsubura A, Kimura M, Kawada A. A case of multiple pilosebaceous cysts. Case Rep Dermatol. 2010;2:116–9.PubMedCrossRefGoogle Scholar
  8. 8.
    Tomkova H, Fujimoto W, Arata J. Expression of keratins (K 10 and K 17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol. 1997;19:250–3.PubMedCrossRefGoogle Scholar
  9. 9.
    Sabater-Marco V, Perez-Ferriols A. Steatocystoma multiplex with smooth muscle. A hamartoma of the pilosebaceous apparatus. Am J Dermatopathol. 1996;18:548–50.PubMedCrossRefGoogle Scholar
  10. 10.
    Plewig G, Wolff HH, Braun-Falco O. Steatocystoma multiplex: anatomic reevaluation, electron microscopy, and autoradiography. Arch Dermatol Res. 1982;272:363–80.PubMedCrossRefGoogle Scholar
  11. 11.
    Lima AM, Rocha SP, Batista CM, Reis CM, Leal II, Azevedo LE. Case for diagnosis. Steatocystoma multiplex. An Bras Dermatol. 2011;86:165–6.Google Scholar
  12. 12.
    Setoyama M, Mizoguchi S, Usuki K, Kanzaki T. Steatocystoma multiplex: a case with unusual clinical and histological manifestation. Am J Dermatopathol. 1997;19:89–92.PubMedCrossRefGoogle Scholar
  13. 13.
    Magid ML, Wentzell JM, Roenick Jr HH. Multiple cystic lesions: steatocystoma multiplex. Arch Dermatol. 1990;126:101. 104.PubMedCrossRefGoogle Scholar
  14. 14.
    Park YM, Cho SH, Kang H. Congenital linear steatocystoma multiplex of the nose. Pediatr Dermatol. 2000;17:136–8.PubMedCrossRefGoogle Scholar
  15. 15.
    Rongioletti F, Cattarini G, Romanelli P. Late onset vulvar steatocystoma multiplex. Clin Exp Dermatol. 2002;27:445–7.PubMedCrossRefGoogle Scholar
  16. 16.
    Stollery N. Photo quiz. Case 2. Steatocystoma multiplex. Practitioner. 2007;251(1701):31. 34.Google Scholar
  17. 17.
    Rollins T, Levin RM, Heymann WR. Acral steatocystoma multiplex. J Am AcadDermatol. 2000;43:396–9.CrossRefGoogle Scholar
  18. 18.
    Mester J, Darwish M, Deshmukh SM. Steatocystoma multiplex of the breast: mammographic and sonographic findings. AJR Am J Roentgenol. 1998;170:115–6.PubMedCrossRefGoogle Scholar
  19. 19.
    Fekete GL, Fekete JE. Steatocystoma multiplex generalisata partially suppurativa-case report. Acta Dermatovenerol Croat. 2010;18:114–9.PubMedGoogle Scholar
  20. 20.
    Kumakiri M, Yajima C. Eruptive steatocystoma multiplex on the scalp. J Dermatol. 1991;18:537–9.PubMedGoogle Scholar
  21. 21.
    Nishimura M, Kohda H, Urabe A. Steatocystoma multiplex. A facial papular variant. Arch Dermatol. 1986;122:205–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Requena L, Martin L, Renedo G, et al. A facial variant of steatocystoma multiplex. Cutis. 1993;51:449–52.PubMedGoogle Scholar
  23. 23.
    Kim SJ, Park HJ, Oh ST, Lee JY, Cho BK. A case of steatocystoma multiplex limited to the scalp. Ann Dermatol. 2009;21:106–9.PubMedCrossRefGoogle Scholar
  24. 24.
    Davey MA. Steatocystoma multiplex treatment & management. In: Elston DM; editor. Medscape reference. http://emedicine.medscape.com/article/1059725-treatment. Accessed 11 Dec 2011.
  25. 25.
    Yamada A, Saga K, Jimbow K. Acquired multiple pilosebaceous cysts on the face having the histopathological features of steatocystoma multiplex and eruptive vellus hair cysts. Int J Dermatol. 2005;44:861–3.PubMedCrossRefGoogle Scholar
  26. 26.
    Thomas VD, Swanson NA, Lee KK. Benign epithelial tumors, hamartomas, and hyperplasias. In: Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffell DJ, editors. Fitzpatrick’s dermatology in general medicine. 7th ed. New York, NY: McGraw-Hill; 2008. p. 1065–6.Google Scholar
  27. 27.
    Cho S, Chang SE, Choi JH, Sung KJ, Moon KC, Koh JK. Clinical and histologic features of 64 cases of steatocystoma multiplex. J Dermatol. 2002;29:152–6.PubMedGoogle Scholar
  28. 28.
    Riedel C, Brinkmeier T, Kutzne H, Plewig G, Frosch PJ. Late onset of a facial variant of steatocystoma multiplex—calretinin as a specific marker of the follicular companion cell layer. J Dtsch Dermatol Ges. 2008;6:480–2.PubMedGoogle Scholar
  29. 29.
    Cuperus E, Leguit RJ, Sigurdsson V. Steatocystoma multiplex, a rare distribution of a rare disease. Eur J Dermatol. 2010;20:402–3.PubMedGoogle Scholar
  30. 30.
    Choudhary S, Koley S, Salodkar A. A modified surgical technique for steatocystoma multiplex. J Cutan Aesthet Surg. 2010;3:25–8.PubMedCrossRefGoogle Scholar
  31. 31.
    Lee SJ, Choe YS, Park BC, Lee WJ, Kim do W. The vein hook successfully used for eradication of steatocystoma multiplex. Dermatol Surg. 2007;33:82–4.PubMedCrossRefGoogle Scholar
  32. 32.
    Düzova AN, Sentürk GB. Suggestion for the treatment of steatocystoma multiplex located exclusively on the face. Int J Dermatol. 2004;43:60–2.PubMedCrossRefGoogle Scholar
  33. 33.
    Apaydin R, Bilen N, Bayramgürler D, Başdaş F, Harova G, Dökmeci S. Steatocystoma multiplex suppurativum: oral isotretinoin treatment combined with cryotherapy. Australas J Dermatol. 2000;41:98–100.PubMedCrossRefGoogle Scholar
  34. 34.
    Madan V, August PJ. Perforation and extirpation of steatocystoma multiplex. Int J Dermatol. 2009;48:329–30.PubMedCrossRefGoogle Scholar
  35. 35.
    Mumcuoğlu CT, Gurel MS, Kiremitci U, Erdemir AV, Karakoca Y, Huten O. Er: yag laser therapy for steatocystoma multiplex. Indian J Dermatol. 2010;55:300–1.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of DermatologyUniversity of MiamiMiamiUSA
  2. 2.Department of Dermatology and Cutaneous Surgery, Veterans HospitalUniversity of MiamiMiamiUSA

Personalised recommendations