Eosinophilic Pustular Folliculitis

  • Joy MakdisiEmail author
  • Adam Friedman


First described in Japan by Ofuji in 1970 [1], eosinophilic pustular folliculitis (EPF) is a noninfectious inflammatory skin disease that manifests with coalescing papulopustular plaques. The disease is histologically characterized by eosinophilic infiltration of hair follicles. There are three known variants of EPF: classic (as originally described by Ofuji and predominantly affecting Japanese individuals), HIV-associated, and infantile.


Hair Follicle Eosinophilic Infiltration Autologous Peripheral Blood Stem Cell Intravenous Drug Abuser Postinflammatory Hyperpigmentation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Ofuji S. Eosinophilic pustular folliculitis. Dermatologica. 1987;174(2):53.PubMedCrossRefGoogle Scholar
  2. 2.
    Nervi SJ, Schwartz RA, Dmochowski M. Eosinophilic pustular folliculitis: a 40 year retrospect. J Am Acad Dermatol. 2006;55(2):285–9.PubMedCrossRefGoogle Scholar
  3. 3.
    Dmochowski M SR. Eosinophilic pustular folliculitis. eMedicine Dermatology [journal serial online]. 2006. Available at: Accessed 15 Dec 2012.
  4. 4.
    Takematsu H, Nakamura K, Igarashi M, Tagami H. Eosinophilic pustular folliculitis. Report of two cases with a review of the Japanese literature. Arch Dermatol. 1985;121(7):917.PubMedCrossRefGoogle Scholar
  5. 5.
    Tang MBY, Tan E, Chua SH. Eosinophilic pustular folliculitis (Ofuji’s disease) in Singapore: a review of 23 adult cases. Australas J Dermatol. 2003;44(1):44–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Ellis E, Scheinfeld N. Eosinophilic pustular folliculitis: a comprehensive review of treatment options. Am J Clin Dermatol. 2004;5(3):189–97.PubMedCrossRefGoogle Scholar
  7. 7.
    Ferrandiz CRM, Barranco JC, Clotet B, Lorenzo JC. Eosinophilic pustular folliculitis in patients with acquired immunodeficiency syndrome. Int J Dermatol. 1992;31(3):193–5.PubMedCrossRefGoogle Scholar
  8. 8.
    Basarab T, Jones RR. HIV‐associated eosinophilic folliculitis: case report and review of the literature. Br J Dermatol. 1996;134(3):499–503.PubMedCrossRefGoogle Scholar
  9. 9.
    Hayes BB, Hille RC, Goldberg LJ. Eosinophilic folliculitis in 2 HIV-positive women. Arch Dermatol. 2004;140(4):463.PubMedCrossRefGoogle Scholar
  10. 10.
    Fearfield L, Rowe A, Francis N, Bunker C, Staughton R. Itchy folliculitis and human immunodeficiency virus infection: clinicopathological and immunological features, pathogenesis and treatment. Br J Dermatol. 1999;141(1):3.PubMedCrossRefGoogle Scholar
  11. 11.
    Haupt HM, Stern JB, Weber CB. Eosinophilic pustular folliculitis: fungal folliculitis? J Am Acad Dermatol. 1990;23(5):1012–4.PubMedCrossRefGoogle Scholar
  12. 12.
    Kimura K, Ezoe K, Yokozeki H, Katayama I, Nishioka K. A case of eosinophilic pustular folliculitis (Ofuji's disease) induced by patch and challenge tests with indeloxazine hydrochloride. J Dermatol. 1996;23(7):479.PubMedGoogle Scholar
  13. 13.
    Maejima H, Mukai H, Hikaru E. Eosinophilic pustular folliculitis induced by allopurinol and timepidium bromide. Acta Derm Venereol. 2002;82(4):316–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Wong TW, Tsai YM, Lee J, Hsu ST, Sheu HM. Eosinophilic pustular folliculitis (Ofuji’s disease) in a patient with silicone tissue augmentation. J Dermatol. 2004;31(9):727.PubMedGoogle Scholar
  15. 15.
    Magro CM, Crowson AN. Eosinophilic pustular follicular reaction: a paradigm of immune dysregulation. Int J Dermatol. 1994;33(3):172–8.PubMedGoogle Scholar
  16. 16.
    Takematsu H, Tagami H. Eosinophilic pustular folliculitis. Studies on possible chemotactic factors involved in the formation of pustules. Br J Dermatol. 2006;114(2):209–15.CrossRefGoogle Scholar
  17. 17.
    Keida T, Hayashi N, Kawashima M. Eosinophilic pustular folliculitis following autologous peripheral blood stem-cell transplantation. J Dermatol. 2004;31(1):21.PubMedGoogle Scholar
  18. 18.
    Johnston R. Chapter 15: Diseases of cutaneous appendages. In: Weedon D, editor. Weedon’s skin pathology essentials. 3rd ed. London: Churchill Livingstone Elsevier; 2012. p. 302.Google Scholar
  19. 19.
    Buchness MR, Lim HW, Soter NA. AIDS-related eosinophilic pustular folliculitis. J Am Acad Dermatol. 1991;25(5 Pt 1):866.PubMedCrossRefGoogle Scholar
  20. 20.
    Soeprono FF, Schinella RA. Eosinophilic pustular folliculitis in patients with acquired immunodeficiency syndrome: report of three cases. J Am Acad Dermatol. 1986;14(6):1020–2.PubMedCrossRefGoogle Scholar
  21. 21.
    Rosenthal D, LeBoit PE, Klumpp L, Berger TG. Human immunodeficiency virus-associated eosinophilic folliculitis: a unique dermatosis associated with advanced human immunodeficiency virus infection. Arch Dermatol. 1991;127(2):206.PubMedCrossRefGoogle Scholar
  22. 22.
    Frentz G, Niordson AM, Thomsen K. Eosinophilic pustular dermatosis: an early skin marker of infection with human immunodeficiency virus? Br J Dermatol. 1989;121(2):271–4.PubMedCrossRefGoogle Scholar
  23. 23.
    Maurer T, Berger T. Serum IgE levels in eosinophilic folliculitis—an inflammatory disease of HIV infection. J Invest Dermatol. 1994;102:619.Google Scholar
  24. 24.
    McCalmont TH, Altemus D, Maurer T, Berger TG. Eosinophilic folliculitis. The histologic spectrum. Am J Dermatopathol. 1995;17(5):439.PubMedCrossRefGoogle Scholar
  25. 25.
    Kabashima K, Sakurai T, Miyachi Y. Treatment of eosinophilic pustular folliculitis (Ofuji’s disease) with tacrolimus ointment. Br J Dermatol. 2004;151(4):949–50.PubMedCrossRefGoogle Scholar
  26. 26.
    Ota T, Hata Y, Tanikawa A, Amagai M, Tanaka M, Nishikawa T. Eosinophilic pustular folliculitis (Ofuji’s disease): indomethacin as a first choice of treatment. Clin Exp Dermatol. 2001; 26(2):179–81.PubMedCrossRefGoogle Scholar
  27. 27.
    Harris D, Ostlere L, Buckley C, Johnson M, Rustin M. Eosinophilic pustular folliculitis in an HIV‐positive man: response to cetirizine. Br J Dermatol. 1992;126(4):392–4.PubMedCrossRefGoogle Scholar
  28. 28.
    Moyle M, Woolley IJ, Thevarajan I, Korman TM. Eosinophilic folliculitis: an example of ‘immune reconstitution folliculitis’? AIDS. 2004;18(17):2350–2.PubMedCrossRefGoogle Scholar
  29. 29.
    Rajendran PM, Dolev JC, Heaphy Jr MR, Maurer T. Eosinophilic folliculitis: before and after the introduction of antiretroviral therapy. Arch Dermatol. 2005;141(10):1227.PubMedCrossRefGoogle Scholar
  30. 30.
    Buchness MR, Lim HW, Hatcher VA, Sanchez M, Soter NA. Eosinophilic pustular folliculitis in the acquired immunodeficiency syndrome. N Engl J Med. 1988;318(18):1183–6.PubMedCrossRefGoogle Scholar
  31. 31.
    Steffen C. Eosinophilic pustular folliculitis (Ofuji’s disease) with response to dapsone therapy. Arch Dermatol. 1985;121:921–3.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of MedicineMontefiore – Albert Einstein College of MedicineBronxUSA

Personalised recommendations