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Muir-Torre Syndrome

  • Adam J. Luber
  • Joshua A. Zeichner
Chapter

Abstract

Muir-Torre syndrome (MTS) is a rare, autosomal dominant genodermatosis characterized by sebaceous neoplasms, keratoacanthomas, and visceral malignancies [1, 2]. MTS is a phenotypic subset of hereditary nonpolyposis colorectal cancer (HNPCC) caused by mutations in mismatch repair genes associated with microsatellite instability [3]. Due to the increased risk in developing visceral malignancies, it is important that the proper diagnosis to be made as early as possible and family members be evaluated for MTS and its associated cancers.

Keywords

Basal Cell Carcinoma Hereditary Nonpolyposis Colorectal Cancer Mismatch Repair Gene Sebaceous Carcinoma MutS Homolog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Adam J. Luber
    • 1
  • Joshua A. Zeichner
    • 2
  1. 1.Department of DermatologyMt Sinai HospitalNew YorkUSA
  2. 2.Department of DermatologyMt. Sinai School of MedicineNew YorkUSA

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