Cushing’s Syndrome

  • Nick Zilieris
  • Cheryl J. GustafsonEmail author
  • Steven R. Feldman


Cushing’s syndrome is a constellation of signs and symptoms due to chronic glucocorticoid excess. Glucocorticoids have far-reaching effects that are not only seen within the body but also seen externally affecting the integumentary system. This chapter will review the pathophysiology, epidemiology, clinical cutaneous manifestations, diagnosis, and treatment of Cushing’s syndrome.


Pituitary Adenoma Sebaceous Gland Adrenal Adenoma Acanthosis Nigricans Adrenal Carcinoma 
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  1. 1.
    Deacon SP. Pituitary-dependent Cushing’s disease. BMJ. 1977;1:1409.PubMedCrossRefGoogle Scholar
  2. 2.
    Boscaro M et al. Cushing’s syndrome. Lancet. 2001;357:783.PubMedCrossRefGoogle Scholar
  3. 3.
    Arlt Wiebke. Disorders of the adrenal cortex (chapter 342). In: Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s principles of internal medicine, 18th ed.
  4. 4.
    Fisher LB, Maibach HI. The effect of corticosteroids on human epidermal mitotic activity. Arch Dermatol. 1971;103:39–44.PubMedCrossRefGoogle Scholar
  5. 5.
    Wilkins L. Professional guide to diseases. 9th ed. 2009;11:631–37.Google Scholar
  6. 6.
    Humes H, et al. Kelley’s textbook of internal medicine, 4th edn. 2000;407:2721–27.Google Scholar
  7. 7.
    James W, Berger T, Elston D. Andrews’ Diseases of the skin: clinical dermatology, vol. 24. 10th ed. London: Saunders; 2005. p. 500–1.Google Scholar
  8. 8.
    Carroll TB, Findling JW.Curr Opin Endocrinol Diabetes Obes. 2009;16(4):308–15. Review Erratum in: Curr Opin Endocrinol Diabetes Obes. 2010;17(5):492.Google Scholar
  9. 9.
    Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J.In: Disorders of the adrenal cortex (chapter 336). Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL, Jameson JL, Loscalzo J, editors. Harrison’s Principles of internal medicine, 17th ed.Google Scholar
  10. 10.
    Freinkel RK. Cutaneous manifestations of endocrine diseases. In: Fitzpatrick TB, Eisen AZ, Wolff K, et al., editors. Dermatology in general medicine. 4th ed. New York: McGraw-Hill; 1993. p. 2113–31.Google Scholar
  11. 11.
    Yanovski JA, Cutler GB. Glucocorticoid action and the clinical features of Cushing’s syndrome. Endocrinol Metab Clin North Am. 1994;23(3):487–509.PubMedGoogle Scholar
  12. 12.
    Orth DN, Kovacs WJ. The adrenal cortex. In: Wilson JD, Foster DW, Kronenberg HM, et al., editors. William’s textbook of endocrinology. 9th ed. Philadelphia: Saunders; 1998. p. 565–9.Google Scholar
  13. 13.
    Rokowski K, Sheehy J, Cutroneo KR. Glucocorticoid-mediated selective reduction of functioning collagen messenger ribonucleic acid. Arch Biochem Biophys. 1981;210:74–81.PubMedCrossRefGoogle Scholar
  14. 14.
    Findling JW, Raff H. Diagnosis and differential diagnosis of Cushing’s syndrome. Endocrinol Metab Clin North Am. 2001;30(3):729–47.PubMedCrossRefGoogle Scholar
  15. 15.
    Lolis MS, Bowe WP, Shalita AR. Acne and systemic disease. Med Clin N Am. 2009;93: 1161–81.PubMedCrossRefGoogle Scholar
  16. 16.
    Ross EJ, Linch DC. Cushing’s syndrome-killing disease: discriminatory value of signs and symptoms aiding early diagnosis. Lancet. 1982;2:646–9.PubMedCrossRefGoogle Scholar
  17. 17.
    Shome B, Saffran M. Peptides of the hypothalamus. J Neurochem. 1966;13(5):433–48.CrossRefGoogle Scholar
  18. 18.
    Meier CA, Biller BM. Clinical and biochemical evaluation of Cushing’s syndrome. Endocrinol Metab Clin North Am. 1997;26:741–62.PubMedCrossRefGoogle Scholar
  19. 19.
    Winkelmann RK, Scheen RS, Underhal LO. Acanthosis nigricans and endocrine disease. JAMA. 1960;174(9):1145–52.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Nick Zilieris
    • 1
  • Cheryl J. Gustafson
    • 2
    Email author
  • Steven R. Feldman
    • 3
  1. 1.Department of Internal MedicineBaptist HospitalMiami BeachUSA
  2. 2.Department of DermatologyWake Forest University Baptist Medical CenterWinston-SalemUSA
  3. 3.Department of Dermatology, Pathology, and Public Health SciencesWake Forest University Baptist Medical CenterWinston-SalemUSA

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