Neuron–Glia Interaction via Neurotrophins
Initially described as target-derived survival factors for neurons, neurotrophins are now known to exert pleiotropic actions as they also regulate neuronal development, function, and plasticity. These processes however are not cell autonomous but derive from the complex interplay between neurons and glia cells.
In this chapter we offer an overview of the current knowledge on the functions supported by neurotrophins in neurons, and focus the attention on the role of neurotrophins in the cross talk between neurons and myelinating cells, microglia, and astrocytes.
KeywordsNerve Growth Factor Schwann Cell Injured Spinal Cord p75NTR Receptor TrkB Signalling
Brain-derived neurotrophic factor
Dorsal root ganglion
LRR and Ig domain containing nogo receptor interacting protein
Nerve growth factor
Oligodendrocyte myelin glycoprotein
Conflict of Interest
The author declares she has no conflict of interest. This chapter does not contain any studies with human or animal subjects.
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