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Neuron–Glia Interaction via Neurotrophins

Chapter
Part of the Advances in Neurobiology book series (NEUROBIOL, volume 7)

Abstract

Initially described as target-derived survival factors for neurons, neurotrophins are now known to exert pleiotropic actions as they also regulate neuronal development, function, and plasticity. These processes however are not cell autonomous but derive from the complex interplay between neurons and glia cells.

In this chapter we offer an overview of the current knowledge on the functions supported by neurotrophins in neurons, and focus the attention on the role of neurotrophins in the cross talk between neurons and myelinating cells, microglia, and astrocytes.

Keywords

Nerve Growth Factor Schwann Cell Injured Spinal Cord p75NTR Receptor TrkB Signalling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

BDNF

Brain-derived neurotrophic factor

DRG

Dorsal root ganglion

LINGO-1

LRR and Ig domain containing nogo receptor interacting protein

LRR

Leucine-rich repeats

LTD

Long-term depression

LTP

Long-term potentiation

MAG

Myelin-associated glycoprotein

NGF

Nerve growth factor

NgR

Nogo receptor

NO

Nitric oxide

NT

Neurotrophin(s)

OL

Oligodendrocyte(s)

OMgp

Oligodendrocyte myelin glycoprotein

SC

Schwann cell(s)

TK

Tyrosine kinase

Notes

Conflict of Interest

The author declares she has no conflict of interest. This chapter does not contain any studies with human or animal subjects.

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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Immunobiology of Neurological Disorders Lab, Division of Neuroscience and Institute of Experimental NeurologySan Raffaele Scientific InstituteMilanItaly

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