Neuron–Glia Interaction via Neurotrophins

Part of the Advances in Neurobiology book series (NEUROBIOL, volume 7)


Initially described as target-derived survival factors for neurons, neurotrophins are now known to exert pleiotropic actions as they also regulate neuronal development, function, and plasticity. These processes however are not cell autonomous but derive from the complex interplay between neurons and glia cells.

In this chapter we offer an overview of the current knowledge on the functions supported by neurotrophins in neurons, and focus the attention on the role of neurotrophins in the cross talk between neurons and myelinating cells, microglia, and astrocytes.


Nerve Growth Factor Schwann Cell Injured Spinal Cord p75NTR Receptor TrkB Signalling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Brain-derived neurotrophic factor


Dorsal root ganglion


LRR and Ig domain containing nogo receptor interacting protein


Leucine-rich repeats


Long-term depression


Long-term potentiation


Myelin-associated glycoprotein


Nerve growth factor


Nogo receptor


Nitric oxide






Oligodendrocyte myelin glycoprotein


Schwann cell(s)


Tyrosine kinase


Conflict of Interest

The author declares she has no conflict of interest. This chapter does not contain any studies with human or animal subjects.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Immunobiology of Neurological Disorders Lab, Division of Neuroscience and Institute of Experimental NeurologySan Raffaele Scientific InstituteMilanItaly

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