Modulation of Developmental Signaling by the Proteostasis Network

  • Kristin D. PattersonEmail author
  • Janice A. Fischer


A few signaling pathways are used repeatedly in the Drosophila larval eye disc to form the ordered array of ommatidia seen in the adult eye. Disruption of signaling by a change in either the levels or timing of expression of signaling pathway components, often leads to dramatic effects: the lack of eye tissue altogether, tumor growth, misdetermination of cell types, altered patterning, or degeneration. The level and timing of signaling in the eye are efficiently controlled by the “proteostasis network”; a collection of mechanisms responsible for the folding, modification, trafficking, and degradation of proteins. We review evidence from the Notch, EGFR, and rhodopsin pathways that the proteostasis network plays a unique and substantial role in enabling the iterative use of signaling pathways in the confines of the developing Drosophila eye and in adult vision.


Epidermal Growth Factor Receptor Notch Signaling Unfold Protein Response Transient Receptor Potential Epidermal Growth Factor Receptor Signaling 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



KDP is supported by a re-entry supplement to NIH Grant No. HD30680 awarded to Janice A. Fischer.


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© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Section of Molecular Cell and Developmental BiologyThe University of Texas at AustinAustinUSA

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