Cell Adhesion During Drosophila Eye Development
Over a brief few days, thousands of cells in the Drosophila eye are organized to generate a precisely patterned functional organ. Eye morphogenesis requires coordinated cell fate specification and differentiation, local cell movements, niche acquisition, and apoptosis to remove surplus cells. The eye has provided a superb model tissue for studies of the molecular bases of these events and the past decade has been punctuated with studies on the adhesion molecules at play as the fly eye develops. Because of its structure—a neuroepithelium composed of several discrete and easily discernable cell types—the eye provides unique opportunities to examine the roles of adhesion between cells as a complex organ is generated. Indeed, dynamic adhesion plays a significant role in orchestrating, regulating, and driving eye morphogenesis.
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