Negative Regulation for Neural Patterning in the Drosophila eye
The Drosophila compound eye is a complex sensory system derived from retinal primordium called the eye imaginal disc. Differentiation of the retinal primordium into different cell types is a key to the visual function of the eye. The fly eye has a simple structure with only a few cell types and a precise organization with a repetitive pattern, thus serving as a favorable model for studying the genetic basis of retinal patterning. An important early event in retinal differentiation is the generation and assembly of neural precursor cells. A number of genes and multiple signaling pathways participate in this process. Many of these genes are involved in promoting the neural differentiation. However, retinal neurogenesis also requires a number of negative factors. Thus, early patterning in the eye is established by interactions between these yin–yang gene activities. This chapter will describe the function of these genetic factors, focusing more on negative regulators that help develop the precise pattern of the adult eye.
KeywordsEpidermal Growth Factor Receptor Lateral Inhibition Epidermal Growth Factor Receptor Signaling Retinal Differentiation Morphogenetic Furrow
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