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Reflux Nephropathy and Vesicoureteral Reflux

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Core Concepts in Parenchymal Kidney Disease

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Abstract

Vesicoureteral reflux in children may be associated with abnormalities of the renal parenchyma. The goals of this chapter are to define (1) what these parenchymal abnormalities are histologically, (2) what their etiologies are thought to be, (3) how they are identified, and 4. what their long-term clinical impact may be. The categories of renal lesions are recognized, renal dysplasia and post-infection, chronic pyelonephritis. The diagnostic gold standard is microscopic evaluation of biopsy specimens but renal scintigraphy can also be used in the diagnosis of renal dysplasia versus chronic pyelonephritis. Potential long-term sequelae of reflux nephropathy include hypertension and renal insufficiency although these are felt to occur rarely.

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Authors and Affiliations

  1. Department of Urology, Harvard School of Medicine, Children’s Hospital, Boston, MA, USA

    Marc Cendron M.D., F.A.A.P.

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  1. Marc Cendron M.D., F.A.A.P.
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Correspondence to Marc Cendron M.D., F.A.A.P. .

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  1. Div. Nephrology & Hypertension, Mayo Clinic Dept. Internal Medicine, Rochester, Minnesota, USA

    Fernando C. Fervenza

  2. Renal Division, Brigham and Women's Hospital, Boston, Massachusetts, USA

    Julie Lin

  3. Mayo Clinic, Rochester, Minnesota, USA

    Sanjeev Sethi

  4. Renal Division, Brigham and Women's Hospital Harvard Medical School, Boston, Massachusetts, USA

    Ajay K. Singh

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Cendron, M. (2014). Reflux Nephropathy and Vesicoureteral Reflux. In: Fervenza, F., Lin, J., Sethi, S., Singh, A. (eds) Core Concepts in Parenchymal Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8166-9_25

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  • DOI: https://doi.org/10.1007/978-1-4614-8166-9_25

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