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Acute Interstitial Nephritis

Abstract

Acute Interstitial nephritis is an inflammatory parenchymal renal disease with major involvement of the tubules and interstitial regions of the kidney. It encompasses many etiologies including idiopathic disease, and forms associated with the use of medications, infectious agents, and autoimmune disorders. Although the mechanisms of renal damage may vary from one etiology to another, cellular interstitial infiltrates and “tubulitis” are hallmarks of the disease process. Clinical features also vary, but most patients present with acute kidney injury which is often non-oliguric in nature. In many medication-related forms the clinical picture is characterized by rash, fever, and eosinophilia, while the urinary findings are of hematuria and eosinophiluria. Therapy must be directed at the underlying etiology of the disease process, but use of steroids and perhaps other immunosuppressives appear to be of value in some patients.

Keywords

  • Acute Kidney Injury
  • Renal Biopsy
  • Interstitial Nephritis
  • Acute Tubular Necrosis
  • Mixed Connective Tissue Disease

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Fig. 23.1

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Correspondence to Gerald B. Appel M.D. .

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Appel, G.B., Appel, A.S. (2014). Acute Interstitial Nephritis. In: Fervenza, F., Lin, J., Sethi, S., Singh, A. (eds) Core Concepts in Parenchymal Kidney Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-8166-9_23

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