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Overview of Neglected Tropical Diseases and Conditions of the Nervous System: Past, Present and Perspectives

  • Marina BentivoglioEmail author
  • Esper A. Cavalheiro
  • Krister Kristensson
  • Nilesh B. Patel
Chapter

Abstract

Neglected tropical diseases consist of a group of infectious diseases with the unifying features of being poverty-related, prevalent in tropical and subtropical regions, and absent from the public health agenda in wealthy countries. In the same world regions, there are “neglected conditions” which also have a negative impact on health. The nervous system involvement in neglected tropical diseases and conditions is an especially neglected field of investigation. Yet, neurological impairments in neglected tropical diseases and conditions constitute together a major category of invalidating disorders, which cause profound changes in nervous system function, often associated with severe sequels or late-onset disturbances. Here are highlighted (1) infectious diseases of the nervous system that nowadays, with the advances of vaccines and antibiotic therapy, are becoming forgotten (2), those belonging to still ravaging neglected tropical diseases, and (3) knowledge perspectives. It is time for clinical and basic neuroscience to be at the forefront and take up the fight against neglected tropical diseases and conditions, and provide means for better management of the patients.

Keywords

Brain disorders Central nervous system Peripheral nervous system Autonomic nervous system Parasites Bacteria Viruses Nematodes Epilepsy Cognition Toxins 

References

  1. Adler J (1997) The dueling diagnoses of Darwin. JAMA 277:1275PubMedCrossRefGoogle Scholar
  2. Akpalu AK (2014) Food preservation, snake venoms and stroke in the tropics. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  3. Bentivoglio M, Kristensson K (2007) Neural-immune interactions in disorders of sleep-wakefulness organization. Trends Neurosci 30:645–652PubMedCrossRefGoogle Scholar
  4. Bentivoglio M, Kristensson K (2014) Tryps and trips: cell trafficking across the 100 year-old blood-brain barrier. Trends Neurosci, in pressGoogle Scholar
  5. Bentivoglio M, Mariotti R, Bertini G (2011) Neuroinflammation and brain infections: historical context and current perspectives. Brain Res Rev 66:152–179PubMedCrossRefGoogle Scholar
  6. Bertarelli E, Figuier L (1915) Conosci te stesso. Nozioni di fisiologia. Treves, MilanGoogle Scholar
  7. Bierne H, Hamon M, Cossart P (2012) Epigenetics and bacterial infections. Cold Spring Harb Perspect Med. doi: 10.1101/cshperspect.a010272 PubMedGoogle Scholar
  8. Bisoffi Z, Buonfrate D, Angheben A (2014) Travel, migration and neglected tropical diseases. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  9. Brain L (1962) Syphilis of the nervous system. In: Brain L (ed) Diseases of the nervous system, 6th edn. Oxford University Press, LondonGoogle Scholar
  10. Buguet A, Mpanzou G, Bentivoglio M (2014) Human African trypanosomiasis: a highly neglected neurological disease. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  11. Carpio A (2014) Neurocysticercosis: neurology and neurobiology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  12. Castellani A (1960) Microbes, men and monarchs. A doctor’s life in many lands. Victor Gollancz, LondonGoogle Scholar
  13. Chagas C (1909) Nova Tripanozomiaze Humana. Estudo sobre a morfolojia e o ciclo evolutivo do Schizotrypanum cruzi n. gen.sp. ajente etiolojico de uma nova entidade mórbida do homem. Mem Inst Oswaldo Cruz 1:159–218CrossRefGoogle Scholar
  14. Coura JR (2014) Chagas disease: neurology and neurobiology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  15. Crosby AW (1972) The Columbian exchange: biological and cultural consequences of 1492. Greenwood, Westport, CTGoogle Scholar
  16. De Kruif P (1926) Microbe hunters. Harcourt, Brace, New YorkGoogle Scholar
  17. Fales FM (2010) Mesopotamia. Handb Clin Neurol 95:15–27PubMedCrossRefGoogle Scholar
  18. Fermi C (1951) La rabbia. Istituto Sieroterapico e Vaccinogeno Toscano “SCLAVO”, SienaGoogle Scholar
  19. Ferrari TCA (2014) Neuroschistosomiasis. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  20. Griffin D (2010) Emergence and re-emergence of viral diseases of the central nervous system. Prog Neurobiol 91:95–101PubMedCentralPubMedCrossRefGoogle Scholar
  21. Hotez PJ (2008) Neglected infections of poverty in the United States of America. PLoS Negl Trop Dis 2:e256Google Scholar
  22. Hotez PJ (2010) Neglected infections of poverty among the indigenous peoples of the Arctic. PLoS Negl Trop Dis 4:e606PubMedCentralPubMedCrossRefGoogle Scholar
  23. Hotez PJ, Gurwith M (2011) Europe’s neglected infections of poverty. Int J Infect Dis 15:e611–e619PubMedCrossRefGoogle Scholar
  24. Hotez PJ, Molyneux DH, Ferwick A, Ottersen E, Ehrlich Sachs S, Sachs JD (2006) Incorporating a rapid-impact package for neglected tropical diseases with programs for HIV/AIDS, tuberculosis, and malaria. PLoS Med 3:e102PubMedCentralPubMedCrossRefGoogle Scholar
  25. Hotez PJ, Molyneux DH, Fenwick A, Kumaresan J, Sachs SE, Sachs JD, Savioli L (2007) Control of neglected tropical diseases. N Engl J Med 357:1018–1027PubMedCrossRefGoogle Scholar
  26. Intapan PM, Maleewong W, Nawa Y (2014) Nematode infections: neurological involvement and neurobiology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  27. Jackson AC (2014) Rabies: neurology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  28. Jay V (2000) The legacy of Armauer Hansen. Arch Pathol Lab Med 124:496–497PubMedGoogle Scholar
  29. Kawli T, He F, Tan M-W (2010) It takes nerves to fight infections: insights on neuro-immune interactions from C. elegans. Dis Model Mech 3:721–731PubMedCentralPubMedCrossRefGoogle Scholar
  30. Kihara M, Abubakar A, Newton CRJC (2014) Cognitive impairment and behavioural disturbances following malaria or HIV infection in childhood. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  31. Kline K, McCarthy JS, Pearson M, Loukas A, Hotez PJ (2013) Neglected tropical diseases of Oceania: review of their prevalence, distribution, and opportunities for control. PLoS Negl Trop Dis 7:e1755PubMedCentralPubMedCrossRefGoogle Scholar
  32. Kristensson K, Olsson Y (1973) Diffusion pathways and retrograde axonal transport of protein tracers in peripheral nerves. Prog Neurobiol 1:87–109PubMedCrossRefGoogle Scholar
  33. Kristensson K, Dastur DK, Manghani DK, Tsiang H, Bentivoglio M (1996) Rabies. Interactions between neurons and viruses. A review of the history Negri inclusion bodies. Neuropathol Appl Neurobiol 22:179–187PubMedCrossRefGoogle Scholar
  34. Lafon M (2014) Rabies: neurobiology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  35. Lechevalier HA, Solotorovsky M (1965) Three centuries of microbiology. McGraw-Hill Inc., New YorkGoogle Scholar
  36. Lockhart J, ed., tr. (1993) We people here: Nahuatl accounts of the conquest of Mexico. University of California Press, Berkeley.Google Scholar
  37. Lubin FD (2012) Epileptogenesis: can the science of epigenetics give us answers? Epilepsy Curr 12:105–110PubMedCentralPubMedCrossRefGoogle Scholar
  38. Masaki T, Rambukkana A (2014) Neurodegeneration in leprosy: insights from model systems and patients. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  39. Masocha W, Kristensson K, Rottenberg ME (2014) Neurobiology of African trypanosomiasis. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  40. Meslin FX, Briggs DJ (2013) Eliminating canine rabies, the principal source of human infection: what will it take? Antiviral Res 98:291–296PubMedCrossRefGoogle Scholar
  41. Misra UK, Kalita J (2014) Japanese encephalitis and dengue virus infection: neurology and neurobiology. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  42. Mokili JL, Rohwer F, Dutilh BE (2012) Metagenomics and future perspectives in virus discovery. Curr Opin Virol 2:63–77PubMedCrossRefGoogle Scholar
  43. Molyneux DH, Hotez PJ, Fenwick A (2005) “Rapid impact interventions”: how a policy of integrated control for Africa’s neglected tropical diseases could benefit the poor. PLoS Med 2(11):e336PubMedCentralPubMedCrossRefGoogle Scholar
  44. Nathanson N (2008) The pathogenesis of poliomyelitis: what we don’t know. Adv Virus Res 71:1–50PubMedCrossRefGoogle Scholar
  45. Newton CR, Wagner RG (2014) Infectious causes of epilepsy? In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  46. Njamnshi AK, Bissek AC, Etya’ale D (2014) Onchocerciasis: neurological involvement. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  47. Odenwald M (2014) Mental health problems associated with the use and abuse of khat (Catha edulis). In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  48. Okitundu D, Mumba D, Tshala-Katumbay D (2014) Konzo: neurology of a permanent and non-progressive motor neuron disorder associated with food (cassava) toxicity. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  49. Patel NB (2014) Neurobiology of khat (Catha edulis Forsk). In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  50. Ribatti D, Nico B, Crivellato E, Artico M (2006) Development of the blood-brain barrier: a historical point of view. Anat Rec B New Anat 289:3–8PubMedCrossRefGoogle Scholar
  51. Schwegmann A, Brombacher F (2008) Host-directed drug targeting of factors hijacked by pathogens. Sci Signal 1(29):re8. doi:10.1126/scisignal.129re8, 1-7Google Scholar
  52. Scorza FA, Yacubian EM, Calderazzo L, Scorza CA, de Albuquerque M, Cavalheiro EA (2013) Training and workforce: an expert panel presents a new approach to epilepsy in the tropics. Clinics 68:127–128PubMedCentralPubMedCrossRefGoogle Scholar
  53. Sherman IW (2006) The power of plagues. ASM, Washington, DCCrossRefGoogle Scholar
  54. Tabah EN, Yepnjio FN, Njamnshi AK (2014) Stigma in neurological diseases in the tropics. In: Bentivoglio M, Cavalheiro EA, Kristensson K, Patel N (eds) Neglected tropical diseases and conditions of the nervous system. Springer, New YorkGoogle Scholar
  55. Triarhou LC (2006) The percipient observations of Constantin von Economo on encephalitis lethargica and sleep disruption and their lasting impact on contemporary sleep research. Brain Res Bull 69:244–258PubMedCrossRefGoogle Scholar
  56. Utzinger J, Becker SL, Knopp S, Blum J, Neumayr AL, Keiser JJ, Hatz CF (2012) Neglected tropical diseases: diagnosis, clinical management, treatment and control. Swiss Med Wkly 142:w13727PubMedGoogle Scholar
  57. Wainwright M (2010) Dyes, trypanosomiasis and DNA: a historical and critical review. Biotech Histochem 85:341–354. doi: 10.3109/10520290903297528 PubMedCrossRefGoogle Scholar
  58. Whitrow M (1990) Wagner-Jauregg and fever therapy. Med Hist 34:294–310PubMedCentralPubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Marina Bentivoglio
    • 1
    Email author
  • Esper A. Cavalheiro
    • 2
  • Krister Kristensson
    • 3
  • Nilesh B. Patel
    • 4
  1. 1.Department of Neurological and Movement Sciences, School of MedicineUniversity of VeronaVeronaItaly
  2. 2.Department of Neurology and NeurosurgeryEscola Paulista de Medicina/Universidade, Federal de São Paulo (EPM/UNIFESP)São PauloBrazil
  3. 3.Department of NeuroscienceKarolinska InstitutetStockholmSweden
  4. 4.Department of Physiology, School of Medicine, College of Health ScienceUniversity of NairobiNairobiKenya

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