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Dendritic Computation of Direction in Retinal Neurons

  • Robert G. Smith
  • W. Rowland Taylor
Chapter
Part of the Springer Series in Computational Neuroscience book series (NEUROSCI, volume 11)

Abstract

The retina utilizes a variety of dendritic mechanisms to compute direction from image motion. The computation is accomplished by starburst amacrine cells (SBACs) which are GABAergic neurons presynaptic to direction-selective ganglion cells (DSGCs). SBACs are symmetric neurons with several branched dendrites radiating out from the soma. Larger EPSPs are produced in the dendritic tips of SBACs as a stimulus sequentially activates inputs from the base of each dendrite outwards. The directional difference in EPSP amplitude is further amplified near the dendritic tips by voltage-gated channels to produce directional release of GABA. Reciprocal inhibition between adjacent SBACs may also amplify directional release. Directional signals in the independent SBAC branches are preserved because each dendrite makes selective contacts only with DSGCs of the appropriate preferred-direction. Directional signals are further enhanced within the dendritic arbor of the DSGC, which essentially comprises an array of distinct dendritic compartments. Each of these dendritic compartments locally sum excitatory and inhibitory inputs, amplifies them with voltage-gated channels, and generates spikes that propagate to the axon via the soma. Overall, the computation of direction in the retina is performed by several local dendritic mechanisms both presynaptic and postsynaptic, with the result that directional responses are robust over a broad range of stimuli.

Keywords

Prefer Direction Bipolar Cell Directional Signal Dendritic Arbor Reciprocal Inhibition 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Thanks to David Vaney for the image of the starburst amacrine cell in Fig. 13.1a. This study was supported by NEI grant EY022070.

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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Department of NeuroscienceUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.Department of OphthalmologySchool of MedicinePortlandUSA

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